Receptors, Adrenergic, alpha-1
Research News and Information

Sunday, November 22, 2009

The sympathetic nervous system in heart failure physiology, pathophysiology, and clinical implications.

Nov 2009 Heart failure is a syndrome characterized initially by left ventricular dysfunction that triggers countermeasures aimed to restore cardiac output. These responses are compensatory at first but eventually become part of the disease process itself ... Read more...

Prostate growth inhibition by subtype-selective alpha(1)-adrenoceptor antagonist naftopidil in benign prostatic hyperplasia.

29 Sep 2009 BACKGROUND: Recently, alpha(1)-adrenoceptors (alpha(1)-ARs) have been reported to play a prominent role in the growth of a variety of cells; however, little is known about prostate growth and subtype-specific effects on cell proliferation. We ... Read more...

The alpha-1D Is the predominant alpha-1-adrenergic receptor subtype in human epicardial coronary arteries.

20 Sep 2009 OBJECTIVES: The goal was to identify alpha-1-adrenergic receptor (AR) subtypes in human coronary arteries. BACKGROUND: The alpha1-ARs regulate human coronary blood flow. The alpha1-ARs exist as 3 molecular subtypes, alpha1A, alpha1B, and alpha1D, ... Read more...

Latest indexed articles for 'Receptors, Adrenergic, alpha-1'

These are the very latest articles for this heading:

• The sympathetic nervous system in heart failure physiology, pathophysiology, and clinical implications. Nov 2009
• Alpha1-adrenergic blockers and intraoperative floppy-iris syndrome. 30 Oct 2009
• Prostate growth inhibition by subtype-selective alpha(1)-adrenoceptor antagonist naftopidil in benign prostatic hyperplasia. 29 Sep 2009
• The alpha-1D Is the predominant alpha-1-adrenergic receptor subtype in human epicardial coronary arteries. 20 Sep 2009
• Buthus tamulus venom-induced vasosensory reflexes are mediated through efferent pathways in sympathetic and vagal parasympathetics. 20 Aug 2009
• DNA synthesis of rat bone marrow mesenchymal stem cells through alpha1-adrenergic receptors. 16 Aug 2009
• Protein tyrosine phosphatase 1B, a major regulator of leptin-mediated control of cardiovascular function. 15 Aug 2009
• Hypophosphatemia-mediated hypotension in transgenic mice overexpressing human FGF-23. 12 Aug 2009
• Synthesis, potency, and in vivo evaluation of 2-piperazin-1-ylquinoline analogues as dual serotonin reuptake inhibitors and serotonin 5-HT1A receptor antagonists. 11 Aug 2009
• Doxazosin-related alpha1-adrenoceptor antagonists with prostate antitumor activity. 11 Aug 2009
• Age-dependent differential crosstalk between alpha(1)-adrenergic and angiotensin receptors. 30 Jul 2009
• Expression of alpha1-adrenoceptors on thymic cells and their role in fine tuning of thymopoiesis. 28 Jul 2009
• Mineralocorticoid and glucocorticoid receptors stimulate epithelial sodium channel activity in a mouse model of Cushing syndrome. 25 Jul 2009
• Marked behavioral activation from inhibitory stimulation of locus coeruleus alpha1-adrenoceptors by a full agonist. 22 Jul 2009
• Sustained stimulation of vasopressin and oxytocin release by ATP and phenylephrine requires recruitment of desensitization-resistant P2X purinergic receptors. 20 Jul 2009
• Impact of alpha 1-adrenergic antagonist use for benign prostatic hypertrophy on outcomes in patients with heart failure. 13 Jul 2009
• Association of adrenergic receptor gene polymorphisms with different fibromyalgia syndrome domains. 29 Jun 2009
• Adventitia removal does not modify the alphaID-adrenoceptors response in aorta during hypertension and ageing. 29 Jun 2009
• Enhancement of the function of rat serotonin and norepinephrine neurons by sustained vagus nerve stimulation. 29 Jun 2009
• Alteration of messenger RNA and protein levels of cardiac alpha(1)-adrenergic receptor and angiotensin II receptor subtypes during aging in rats. 29 Jun 2009

See a longer list of these articles.

Technical information about 'Receptors, Adrenergic, alpha-1'

Definition: A subclass of alpha-adrenergic receptors (RECEPTORS, ADRENERGIC, ALPHA). alpha-1 Adrenergic receptors can be pharmacologically discriminated, e.g., by their high affinity for the agonist phenylephrine and the antagonist prazosin. They are widespread, with clinically important concentrations in the liver, the heart, vascular, intestinal, and genitourinary smooth muscle, and the central and peripheral nervous systems.

Registry Number: 0

Descriptor UI: D018340

Alternative terms: Receptors, Adrenergic, alpha-1; Receptor, Adrenergic, alpha-1; alpha 1 Adrenergic Receptor; Adrenergic alpha-1 Receptors; Adrenergic alpha 1 Receptors; Receptors, Adrenergic alpha-1; alpha-1 Receptors, Adrenergic; Receptors, alpha-1 Adrenergic; Receptors, alpha 1 Adrenergic; Adrenergic Receptor, alpha-1; Adrenergic Receptor, alpha 1; Receptor, alpha-1 Adrenergic; alpha-1 Adrenergic Receptor; alpha-1 Adrenergic Receptors; Adrenergic Receptors, alpha-1; alpha 1 Adrenergic Receptors;

Allowable Qualifiers: administration & dosage; analysis; antagonists & inhibitors; biosynthesis; blood; classification; deficiency; drug effects; genetics; history; immunology; isolation & purification; metabolism; physiology; radiation effects; therapeutic use; ultrastructure; chemistry; agonists;

Tree Number: D12.776.543.750.070.300.300.300.700; D12.776.543.750.100.150.300.300.700; D12.776.543.750.720.300.300.300.300.100;

History Note: 94