Receptors, Adrenergic, alpha-2 - Drug effects
Research News and Information

Sunday, November 22, 2009

Gastroprotective effect of lupeol on ethanol-induced gastric damage and the underlying mechanism.

14 Jul 2009 The effect of lupeol, a natural pentacyclic triterpene on ethanol-induced gastric damage in mice was evaluated. The gastroprotection was assessed by determination of changes in mean gastric lesion area, quantification of mucosal non-protein ... Read more...

Pharmacology of sedative-analgesic agents: dexmedetomidine, remifentanil, ketamine, volatile anesthetics, and the role of peripheral mu antagonists.

29 Jun 2009 In this article, the authors discuss the pharmacology of sedative-analgesic agents like dexmedetomidine, remifentanil, ketamine, and volatile anesthetics. Dexmedetomidine is a highly selective alpha-2 agonist that provides anxiolysis and cooperative ... Read more...

Alpha2-adrenergic receptors attenuate secretagogue-induced endocytosis and promote exocytosis of intestinal NHE2 and NHE3.

23 Jun 2009 Adrenergic agonists, through activation of intestinal epithelial alpha2-adrenergic receptors (alpha2AR), inhibit electrolyte secretion and promote absorption. The mechanisms of action to promote basal Na(+) absorption and inhibit stimulated ... Read more...

Latest indexed articles for 'Receptors, Adrenergic, alpha-2 - Drug effects'

These are the very latest articles for this heading:

• Gastroprotective effect of lupeol on ethanol-induced gastric damage and the underlying mechanism. 14 Jul 2009
• Pharmacology of sedative-analgesic agents: dexmedetomidine, remifentanil, ketamine, volatile anesthetics, and the role of peripheral mu antagonists. 29 Jun 2009
• Alpha2-adrenergic receptors attenuate secretagogue-induced endocytosis and promote exocytosis of intestinal NHE2 and NHE3. 23 Jun 2009
• ERK phosphorylation in intact, adult brain by alpha(2)-adrenergic transactivation of EGF receptors. 4 Jun 2009
• The identification of a novel phosphodiesterase 4 inhibitor, 1-ethyl-5-{5-[(4-methyl-1-piperazinyl)methyl]-1,3,4-oxadiazol-2-yl}-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (EPPA-1), with improved therapeutic index using pica feeding in rats as a measure of emetogenicity. 2 Jun 2009
• alpha(2)-Adrenoceptor subtypes-mediated physiological, pharmacological actions. 25 May 2009
• The P2Y(1) and P2Y(12) receptors mediate autoinhibition of transmitter release in sympathetic innervated tissues. 13 May 2009
• Comparative pharmacology of adrenergic alpha(2C) receptors coupled to Ca(2+) signaling through different Galpha proteins. 4 May 2009
• Treating agitation with dexmedetomidine in the ICU. 29 Apr 2009
• Involvement of central alpha1-adrenoceptors on renal responses to central moxonidine and alpha-methylnoradrenaline. 30 Mar 2009
• Anxiolytics antagonize yohimbine-induced central noradrenergic activity: a concomitant in vivo voltammetry-electrophysiology model of anxiety. 19 Mar 2009
• The effect of growth hormone releasing peptide-2 on upper gastrointestinal contractile activity and food intake in conscious dogs. 5 Mar 2009
• beta-1 and beta-2, but not alpha-1 and alpha-2, adrenoceptor blockade delays rat cutaneous wound healing. 27 Feb 2009
• Testing conception of engagement of imidazoline receptors in imidazoline drugs effects on isolated rat heart atria. 27 Feb 2009
• Use of transgenic (knockout) mice reveals a site distinct from the alpha2A-adrenoceptors for agmatine in the vas deferens. 27 Feb 2009
• Guanidine and 2-aminoimidazoline aromatic derivatives as alpha2-adrenoceptor ligands: searching for structure-activity relationships. 10 Feb 2009
• Dopamine vs noradrenaline: inverted-U effects and ADHD theories. 30 Jan 2009
• Alpha-1-adrenergic receptor agonist activity of clinical alpha-adrenergic receptor agonists interferes with alpha-2-mediated analgesia. 30 Jan 2009
• Effect of dexmedetomidine on the characteristics of bupivacaine in a caudal block in pediatrics. 4 Dec 2008
• Determination of adrenergic and imidazoline receptor involvement in augmentation of morphine and oxycodone analgesia by clonidine and BMS182874. 2 Dec 2008

See a longer list of these articles.

Technical information about 'Receptors, Adrenergic, alpha-2'

Definition: A subclass of alpha-adrenergic receptors (RECEPTORS, ADRENERGIC, ALPHA). alpha-2 Adrenergic receptors can be pharmacologically discriminated, e.g., by their high affinity for the agonist clonidine and the antagonist yohimbine. They are found on pancreatic beta cells, platelets, and VASCULAR SMOOTH MUSCLE, as well as both pre- and postsynaptically in the central and peripheral nervous systems.

Registry Number: 0

Descriptor UI: D018341

Alternative terms: Receptors, Adrenergic, alpha-2; Adrenergic Receptor, alpha-2; Adrenergic Receptor, alpha 2; Receptor, alpha-2 Adrenergic; alpha-2 Adrenergic Receptor; Receptors, alpha-2 Adrenergic; Receptors, alpha 2 Adrenergic; alpha-2 Adrenergic Receptors; Adrenergic Receptors, alpha-2; Receptor, Adrenergic, alpha-2; Adrenergic alpha-2 Receptors; Adrenergic alpha 2 Receptors; Receptors, Adrenergic alpha-2; alpha-2 Receptors, Adrenergic; alpha 2 Adrenergic Receptors;

Allowable Qualifiers: administration & dosage; analysis; antagonists & inhibitors; biosynthesis; blood; classification; deficiency; drug effects; genetics; history; immunology; isolation & purification; metabolism; physiology; radiation effects; therapeutic use; ultrastructure; chemistry; agonists;

Tree Number: D12.776.543.750.070.300.300.300.725; D12.776.543.750.100.150.300.300.725; D12.776.543.750.720.300.300.300.300.200;

History Note: 94