Receptors, Adrenergic, alpha-2 - Metabolism
Research News and Information

Sunday, November 22, 2009

Protein kinase C mediates the synergistic interaction between agonists acting at alpha2-adrenergic and delta-opioid receptors in spinal cord.

19 Oct 2009 Coactivation of spinal alpha(2)-adrenergic receptors (ARs) and opioid receptors produces antinociceptive synergy. Antinociceptive synergy between intrathecally administered alpha(2)AR and opioid agonists is well documented, but the mechanism ... Read more...

Insertion/deletion polymorphism in alpha2-adrenergic receptor gene is a genetic risk factor for sudden cardiac death.

29 Sep 2009 BACKGROUND: Adrenoceptors mediate contraction of vascular smooth muscle and induce coronary vasoconstriction in humans. A deletion variant of the human alpha(2B)-adrenoreseptor of glutamic acid residues has been associated with impaired receptor ... Read more...

Stress, genotype and norepinephrine in the prediction of mouse behavior using reinforcement learning.

14 Aug 2009 Individual behavioral performance during learning is known to be affected by modulatory factors, such as stress and motivation, and by genetic predispositions that influence sensitivity to these factors. Despite numerous studies, no integrative ... Read more...

Latest indexed articles for 'Receptors, Adrenergic, alpha-2 - Metabolism'

These are the very latest articles for this heading:

• Protein kinase C mediates the synergistic interaction between agonists acting at alpha2-adrenergic and delta-opioid receptors in spinal cord. 19 Oct 2009
• Insertion/deletion polymorphism in alpha2-adrenergic receptor gene is a genetic risk factor for sudden cardiac death. 29 Sep 2009
• Stress, genotype and norepinephrine in the prediction of mouse behavior using reinforcement learning. 14 Aug 2009
• Effects of glutamate and alpha2-noradrenergic receptor antagonists on the development of neurotoxicity produced by chronic rotenone in rats. 15 Jul 2009
• Gastroprotective effect of lupeol on ethanol-induced gastric damage and the underlying mechanism. 14 Jul 2009
• Modulation of alpha2-adrenoceptor functions by heterotrimeric Galphai protein isoforms. 7 Jul 2009
• Cardiac anti-remodelling effect of aerobic training is associated with a reduction in the calcineurin/NFAT signalling pathway in heart failure mice. 6 Jun 2009
• Extracellular norepinephrine, norepinephrine receptor and transporter protein and mRNA levels are differentially altered in the developing rat brain due to dietary iron deficiency and manganese exposure. 26 May 2009
• Interaction of the ubiquitin carboxyl terminal esterase L1 with alpha(2)-adrenergic receptors inhibits agonist-mediated p44/42 MAP kinase activation. 25 May 2009
• The P2Y(1) and P2Y(12) receptors mediate autoinhibition of transmitter release in sympathetic innervated tissues. 13 May 2009
• Molecular modelling of subtypes (alpha(2A), alpha(2B) and alpha(2C)) of alpha(2)-adrenoceptors: a comparative study. 13 May 2009
• Pivotal role of the alpha(2A)-adrenoceptor in producing inflammation and organ injury in a rat model of sepsis. 9 May 2009
• Dorsomedial pontine neurons with descending projections to the medullary reticular formation express orexin-1 and adrenergic alpha2A receptor mRNA. 5 May 2009
• 6,7-Dihydro-5H-pyrrolo[1,2-a] imidazoles as potent and selective alpha1A adrenoceptor partial agonists. 16 Apr 2009
• Potent and selective alpha1A adrenoceptor partial agonists--novel imidazole frameworks. 5 Apr 2009
• Role of alpha-2 adrenergic receptors in anti-ulcer effect mechanism of estrogen and luteinising hormone on rats. 30 Mar 2009
• Involvement of central alpha1-adrenoceptors on renal responses to central moxonidine and alpha-methylnoradrenaline. 30 Mar 2009
• Effect of moxonidine on the uveoscleral outflow: role of alpha2-adrenoceptors or i1 imidazoline receptors. 30 Mar 2009
• Coexpression of alpha 2A-adrenergic and delta-opioid receptors in substance P-containing terminals in rat dorsal horn. 30 Mar 2009
• Analysis of alpha2-adrenergic receptors and effect of brimonidine on matrix metalloproteinases and their inhibitors in human ciliary body. 23 Mar 2009

See a longer list of these articles.

Technical information about 'Receptors, Adrenergic, alpha-2'

Definition: A subclass of alpha-adrenergic receptors (RECEPTORS, ADRENERGIC, ALPHA). alpha-2 Adrenergic receptors can be pharmacologically discriminated, e.g., by their high affinity for the agonist clonidine and the antagonist yohimbine. They are found on pancreatic beta cells, platelets, and VASCULAR SMOOTH MUSCLE, as well as both pre- and postsynaptically in the central and peripheral nervous systems.

Registry Number: 0

Descriptor UI: D018341

Alternative terms: Receptors, Adrenergic, alpha-2; Adrenergic Receptor, alpha-2; Adrenergic Receptor, alpha 2; Receptor, alpha-2 Adrenergic; alpha-2 Adrenergic Receptor; Receptors, alpha-2 Adrenergic; Receptors, alpha 2 Adrenergic; alpha-2 Adrenergic Receptors; Adrenergic Receptors, alpha-2; Receptor, Adrenergic, alpha-2; Adrenergic alpha-2 Receptors; Adrenergic alpha 2 Receptors; Receptors, Adrenergic alpha-2; alpha-2 Receptors, Adrenergic; alpha 2 Adrenergic Receptors;

Allowable Qualifiers: administration & dosage; analysis; antagonists & inhibitors; biosynthesis; blood; classification; deficiency; drug effects; genetics; history; immunology; isolation & purification; metabolism; physiology; radiation effects; therapeutic use; ultrastructure; chemistry; agonists;

Tree Number: D12.776.543.750.070.300.300.300.725; D12.776.543.750.100.150.300.300.725; D12.776.543.750.720.300.300.300.300.200;

History Note: 94