Receptors, Adrenergic, alpha-2
Research News and Information

Sunday, November 22, 2009

Protein kinase C mediates the synergistic interaction between agonists acting at alpha2-adrenergic and delta-opioid receptors in spinal cord.

19 Oct 2009 Coactivation of spinal alpha(2)-adrenergic receptors (ARs) and opioid receptors produces antinociceptive synergy. Antinociceptive synergy between intrathecally administered alpha(2)AR and opioid agonists is well documented, but the mechanism ... Read more...

Insertion/deletion polymorphism in alpha2-adrenergic receptor gene is a genetic risk factor for sudden cardiac death.

29 Sep 2009 BACKGROUND: Adrenoceptors mediate contraction of vascular smooth muscle and induce coronary vasoconstriction in humans. A deletion variant of the human alpha(2B)-adrenoreseptor of glutamic acid residues has been associated with impaired receptor ... Read more...

Noradrenergic modulation of neuronal responses to glutamate in the vestibular complex.

18 Aug 2009 Increases in firing rate induced in secondary vestibular neurons by microiontophoretic application of glutamate were studied during long-lasting applications of noradrenaline (NA) and/or its antagonists and agonists. Sixty-nine percent of the tested ... Read more...

Latest indexed articles for 'Receptors, Adrenergic, alpha-2'

These are the very latest articles for this heading:

• Protein kinase C mediates the synergistic interaction between agonists acting at alpha2-adrenergic and delta-opioid receptors in spinal cord. 19 Oct 2009
• Insertion/deletion polymorphism in alpha2-adrenergic receptor gene is a genetic risk factor for sudden cardiac death. 29 Sep 2009
• Noradrenergic modulation of neuronal responses to glutamate in the vestibular complex. 18 Aug 2009
• Alpha2-receptor agonists for treatment and prevention of iatrogenic opioid abstinence syndrome in critically ill patients. 16 Aug 2009
• Stress, genotype and norepinephrine in the prediction of mouse behavior using reinforcement learning. 14 Aug 2009
• Pediatric pharmacology in the first year of life. 30 Jul 2009
• Can attenuation of the perioperative stress response prevent intermediate or long-term cardiovascular outcomes among patients undergoing noncardiac surgery? 30 Jul 2009
• Marked behavioral activation from inhibitory stimulation of locus coeruleus alpha1-adrenoceptors by a full agonist. 22 Jul 2009
• Hypothermic responses to infection are inhibited by alpha2-adrenoceptor agonists with possible clinical implications. 21 Jul 2009
• Effects of glutamate and alpha2-noradrenergic receptor antagonists on the development of neurotoxicity produced by chronic rotenone in rats. 15 Jul 2009
• Gastroprotective effect of lupeol on ethanol-induced gastric damage and the underlying mechanism. 14 Jul 2009
• Modulation of alpha2-adrenoceptor functions by heterotrimeric Galphai protein isoforms. 7 Jul 2009
• Pharmacology of sedative-analgesic agents: dexmedetomidine, remifentanil, ketamine, volatile anesthetics, and the role of peripheral mu antagonists. 29 Jun 2009
• Interaction of morphine but not fentanyl with cerebral alpha2-adrenoceptors in alpha2-adrenoceptor knockout mice. 29 Jun 2009
• Alpha2-adrenergic receptors attenuate secretagogue-induced endocytosis and promote exocytosis of intestinal NHE2 and NHE3. 23 Jun 2009
• Pharmacological characterization of the inhibition by moxonidine and agmatine on the cardioaccelerator sympathetic outflow in pithed rats. 11 Jun 2009
• Pharmacological analysis of alpha(2)-adrenoceptor subtypes mediating analgesic, anti-inflammatory and gastroprotective actions. 11 Jun 2009
• Guanfacine potentiates the activation of prefrontal cortex evoked by warning signals. 9 Jun 2009
• Clonidine induces calcitonin gene-related peptide expression via nitric oxide pathway in endothelial cells. 7 Jun 2009
• Candidate gene studies of ADHD: a meta-analytic review. 7 Jun 2009

See a longer list of these articles.

Technical information about 'Receptors, Adrenergic, alpha-2'

Definition: A subclass of alpha-adrenergic receptors (RECEPTORS, ADRENERGIC, ALPHA). alpha-2 Adrenergic receptors can be pharmacologically discriminated, e.g., by their high affinity for the agonist clonidine and the antagonist yohimbine. They are found on pancreatic beta cells, platelets, and VASCULAR SMOOTH MUSCLE, as well as both pre- and postsynaptically in the central and peripheral nervous systems.

Registry Number: 0

Descriptor UI: D018341

Alternative terms: Receptors, Adrenergic, alpha-2; Adrenergic Receptor, alpha-2; Adrenergic Receptor, alpha 2; Receptor, alpha-2 Adrenergic; alpha-2 Adrenergic Receptor; Receptors, alpha-2 Adrenergic; Receptors, alpha 2 Adrenergic; alpha-2 Adrenergic Receptors; Adrenergic Receptors, alpha-2; Receptor, Adrenergic, alpha-2; Adrenergic alpha-2 Receptors; Adrenergic alpha 2 Receptors; Receptors, Adrenergic alpha-2; alpha-2 Receptors, Adrenergic; alpha 2 Adrenergic Receptors;

Allowable Qualifiers: administration & dosage; analysis; antagonists & inhibitors; biosynthesis; blood; classification; deficiency; drug effects; genetics; history; immunology; isolation & purification; metabolism; physiology; radiation effects; therapeutic use; ultrastructure; chemistry; agonists;

Tree Number: D12.776.543.750.070.300.300.300.725; D12.776.543.750.100.150.300.300.725; D12.776.543.750.720.300.300.300.300.200;

History Note: 94