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Receptors, AMPA - Metabolism
Research News and Information
Definition of 'Receptors, AMPA'Cell surface proteins that bind glutamate and directly gate ion channels in cell membranes. AMPA receptors were originally discriminated from other glutamate receptors by their affinity for the agonist AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid). They are probably the most common mediators of fast excitatory synaptic transmission in the central nervous system. Several subtypes have been cloned, and for some types the traditional distinction from kainate receptors may not apply. |
Saturday, November 21, 2009
19 Oct 2009 
Pure NMDA receptor (NMDAr)-mediated EPSCs, thought to correspond to "silent" glutamatergic synapses that lack AMPA receptors (AMPArs), have been observed in superficial spinal dorsal horn of neonatal but not adult rats. Recent anatomical studies ... Read more...
12 Oct 2009 To examine the intrasynaptic arrangement of postsynaptic receptors in relation to the functional role of the synapse, we quantitatively analyzed the two-dimensional distribution of AMPA and NMDA receptors (AMPARs and NMDARs, respectively) using ... Read more...
DCP-LA stimulates AMPA receptor exocytosis through CaMKII activation due to PP-1 inhibition.
29 Sep 2009 The linoleic acid derivative 8-[2-(2-pentyl-cyclopropylmethyl)-cyclopropyl]-octanoic acid (DCP-LA) activated Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) by inhibiting protein phosphatase-1 (PP-1). DCP-LA induced a transient huge ... Read more...
Latest indexed articles for 'Receptors, AMPA - Metabolism'
These are the very latest articles for this heading:
- Evidence against AMPA receptor-lacking glutamatergic synapses in the superficial dorsal horn of the rat spinal cord. 19 Oct 2009
- Input-specific intrasynaptic arrangements of ionotropic glutamate receptors and their impact on postsynaptic responses. 12 Oct 2009
- DCP-LA stimulates AMPA receptor exocytosis through CaMKII activation due to PP-1 inhibition. 29 Sep 2009
- Glutamate controls growth rate and branching of dopaminergic axons. 21 Sep 2009
- NMDA receptor phosphorylation at a site affected in schizophrenia controls synaptic and behavioral plasticity. 21 Sep 2009
- AMPA receptor ligand binding domain mobility revealed by functional cross linking. 21 Sep 2009
- Vagal gustatory reflex circuits for intraoral food sorting behavior in the goldfish: cellular organization and neurotransmitters. 18 Sep 2009
- Synaptic PRG-1 modulates excitatory transmission via lipid phosphate-mediated signaling. 16 Sep 2009
- Probing the allosteric modulator binding site of GluR2 with thiazide derivatives. 13 Sep 2009
- S-nitrosylation of stargazin regulates surface expression of AMPA-glutamate neurotransmitter receptors. 8 Sep 2009
- BDNF and NT-3 increase excitatory input connectivity in rat hippocampal cultures. 30 Aug 2009
- Galantamine enhancement of long-term potentiation is mediated by calcium/calmodulin-dependent protein kinase II and protein kinase C activation. 30 Aug 2009
- Neurogranin enhances synaptic strength through its interaction with calmodulin. 25 Aug 2009
- Otoferlin is critical for a highly sensitive and linear calcium-dependent exocytosis at vestibular hair cell ribbon synapses. 24 Aug 2009
- Quantitative morphometry of electrophysiologically identified CA3b interneurons reveals robust local geometry and distinct cell classes. 18 Aug 2009
- Diabetes changes the levels of ionotropic glutamate receptors in the rat retina. 15 Aug 2009
- Nucleus accumbens neurons exhibit synaptic scaling that is occluded by repeated dopamine pre-exposure. 5 Aug 2009
- Early development of the thalamic inhibitory feedback loop in the primary somatosensory system of the newborn mice. 3 Aug 2009
- The principal neurons of the medial nucleus of the trapezoid body and NG2(+) glial cells receive coordinated excitatory synaptic input. 30 Jul 2009
- Age-dependent enhancement of inhibitory synaptic transmission in CA1 pyramidal neurons via GluR5 kainate receptors. 30 Jul 2009
See a longer list of these articles.
Technical information about 'Receptors, AMPA'
Definition: Cell surface proteins that bind glutamate and directly gate ion channels in cell membranes. AMPA receptors were originally discriminated from other glutamate receptors by their affinity for the agonist AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid). They are probably the most common mediators of fast excitatory synaptic transmission in the central nervous system. Several subtypes have been cloned, and for some types the traditional distinction from kainate receptors may not apply.
Registry Number: 0
Descriptor UI: D018091
Alternative terms: Receptors, AMPA; AMPA Receptor; Receptor, AMPA; AMPA Receptors; Quisqualate Receptor; Receptor, Quisqualate; Quisqualate Receptors; Receptors, Quisqualate;
Allowable Qualifiers: administration & dosage; analysis; antagonists & inhibitors; biosynthesis; blood; classification; deficiency; drug effects; genetics; history; immunology; isolation & purification; metabolism; physiology; radiation effects; therapeutic use; ultrastructure; chemistry; agonists;
Tree Number: D12.776.543.750.720.200.450.200;
Online Note: use RECEPTORS, AMPA (NM) to search AMPA RECEPTOR 1981-93
History Note: 94; was AMPA RECEPTOR (NM) 1981-93
Technical Notes: DF: RECEPT AMPA