Receptors, Aryl Hydrocarbon - Metabolism
Research News and Information

Thursday, March 18, 2010

Modeling of the aryl hydrocarbon receptor (AhR) ligand binding domain and its utility in virtual ligand screening to predict new AhR ligands.

22 Sep 2009 The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor; the AhR Per-AhR/Arnt-Sim (PAS) domain binds ligands. We developed homology models of the AhR PAS domain to characterize previously observed intra- and interspecies ... Read more...

Knockdown of the aryl hydrocarbon receptor attenuates excitotoxicity and enhances NMDA-induced BDNF expression in cortical neurons.

25 Aug 2009 NMDA receptors play dual and opposing roles in neuronal survival by mediating the activity-dependent neurotrophic signaling and excitotoxic cell death via synaptic and extrasynaptic receptors, respectively. In this study, we demonstrate that the ... Read more...

Aryl hydrocarbon receptor in combination with Stat1 regulates LPS-induced inflammatory responses.

22 Aug 2009 Toll-like receptor (TLR) signals perform a crucial role in innate immune responses to pathogens. In this study, we found that the aryl hydrocarbon receptor (Ahr) negatively regulates inflammatory responses mediated by lipopolysaccharide (LPS) in ... Read more...

Latest indexed articles for 'Receptors, Aryl Hydrocarbon - Metabolism'

These are the very latest articles for this heading:

• Modeling of the aryl hydrocarbon receptor (AhR) ligand binding domain and its utility in virtual ligand screening to predict new AhR ligands. 22 Sep 2009
• Knockdown of the aryl hydrocarbon receptor attenuates excitotoxicity and enhances NMDA-induced BDNF expression in cortical neurons. 25 Aug 2009
• Aryl hydrocarbon receptor in combination with Stat1 regulates LPS-induced inflammatory responses. 22 Aug 2009
• Beyond toxicity: aryl hydrocarbon receptor-mediated functions in the immune system. 15 Aug 2009
• Aryl hydrocarbon receptor activation and overexpression upregulated fibroblast growth factor-9 in human lung adenocarcinomas. 13 Aug 2009
• Interleukin-17-producing gammadelta T cells selectively expand in response to pathogen products and environmental signals. 11 Aug 2009
• Amnesic shellfish poisoning toxin stimulates the transcription of CYP1A possibly through AHR and ARNT in the liver of red sea bream Pagrus major. 6 Aug 2009
• Nedd9/Hef1/Cas-L mediates the effects of environmental pollutants on cell migration and plasticity. Aug 2009
• Molecular basis of tobacco smoke-induced premature skin aging. 30 Jul 2009
• Aryl hydrocarbon receptor suppresses intestinal carcinogenesis in ApcMin/+ mice with natural ligands. 25 Jul 2009
• In vitro assessment of AhR-mediated activities of TCDD in mixture with humic substances. 15 Jul 2009
• Glucocorticoid and adrenalectomy effects on the rat aryl hydrocarbon receptor pathway depend on the dosing regimen and post-surgical time. 14 Jul 2009
• The tryptophan photoproduct 6-formylindolo[3,2-b]carbazole (FICZ) binds multiple AHRs and induces multiple CYP1 genes via AHR2 in zebrafish. 13 Jul 2009
• Activation of aryl hydrocarbon receptor signaling by cotton balls used for environmental enrichment. 29 Jun 2009
• Detection of the TCDD binding-fingerprint within the Ah receptor ligand binding domain by structurally driven mutagenesis and functional analysis. 28 Jun 2009
• Characterization of the region of the aryl hydrocarbon receptor required for ligand dependency of transactivation using chimeric receptor between Drosophila and Mus musculus. 23 Jun 2009
• Aryl hydrocarbon receptor is an ozone sensor in human skin. 16 Jun 2009
• Aryl hydrocarbon receptor activation inhibits in vitro differentiation of human monocytes and Langerhans dendritic cells. 15 Jun 2009
• Effect of dioxins on regulation of tyrosine hydroxylase gene expression by aryl hydrocarbon receptor: a neurotoxicology study. 4 Jun 2009
• Distinct roles of two zebrafish AHR repressors (AHRRa and AHRRb) in embryonic development and regulating the response to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Jun 2009

See a longer list of these articles.

Technical information about 'Receptors, Aryl Hydrocarbon'

Definition: Cytoplasmic proteins that bind certain aryl hydrocarbons, translocate to the nucleus, and activate transcription of particular DNA segments. AH receptors are identified by their high-affinity binding to several carcinogenic or teratogenic environmental chemicals including polycyclic aromatic hydrocarbons found in cigarette smoke and smog, heterocyclic amines found in cooked foods, and halogenated hydrocarbons including dioxins and polychlorinated biphenyls. No endogenous ligand has been identified, but an unknown natural messenger with a role in cell differentiation and development is suspected.

Registry Number: 0

Descriptor UI: D018336

Alternative terms: Receptors, Aryl Hydrocarbon; Receptors, AH; Aryl Hydrocarbon Receptors; Dioxin Receptor; Receptor, Dioxin; Dioxin Receptors; Receptors, Dioxin; Polyaromatic Hydrocarbon Receptors; Polyaromatic Hydrocarbon Receptor; Receptor, Polyaromatic Hydrocarbon; Receptors, Polyaromatic Hydrocarbon; TCDD Receptor; Receptor, TCDD; Receptors, TCDD; TCDD Receptors; AH Receptor; Receptor, AH; AH Receptors; Receptors, 2,3,7,8-Tetrachlorodibenzo-p-dioxin; Aryl Hydrocarbon Receptor; Receptor, Aryl Hydrocarbon;

Allowable Qualifiers: administration & dosage; analysis; antagonists & inhibitors; biosynthesis; blood; classification; deficiency; drug effects; genetics; history; immunology; isolation & purification; metabolism; physiology; radiation effects; therapeutic use; ultrastructure; chemistry; agonists;

Tree Number: D12.776.826.480; D12.776.930.662;

Online Note: use RECEPTORS, ARYL HYDROCARBON (NM) to search 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN RECEPTOR 1980-93 & ARYL HYDROCARBON RECEPTOR 1981-93

History Note: 94; was ARYL HYDROCARBON RECEPTOR (NM) 1981-93; 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN RECEPTOR was (NM) 1979-93

Technical Notes: DF: RECEPT AH