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Receptors, Cholinergic - Chemistry
Research News and Information
Definition of 'Receptors, Cholinergic'Cell surface proteins that bind acetylcholine with high affinity and trigger intracellular changes influencing the behavior of cells. Cholinergic receptors are divided into two major classes, muscarinic and nicotinic, based originally on their affinity for nicotine and muscarine. Each group is further subdivided based on pharmacology, location, mode of action, and/or molecular biology. Common names: Receptors, Cholinergic; Receptors, Acetylcholine; Cholinoceptive Sites; Sites, Cholinoceptive; Receptors, ACh; Cholinergic Receptors; ACh Receptors; Acetylcholine Receptors; Cholinoceptors |
Monday, November 23, 2009
Crystal structure of the frizzled-like cysteine-rich domain of the receptor tyrosine kinase MuSK.
2 Aug 2009 
Muscle-specific kinase (MuSK) is an essential receptor tyrosine kinase for the establishment and maintenance of the neuromuscular junction (NMJ). Activation of MuSK by agrin, a neuronally derived heparan-sulfate proteoglycan, and LRP4 (low-density ... Read more...
Energy and structure of the M2 helix in acetylcholine receptor-channel gating.
18 May 2009 We studied single-channel currents from neuromuscular acetylcholine receptor-channels with mutations in the pore-lining, M2 helix of the epsilon-subunit. Three parameters were quantified: 1), the diliganded gating equilibrium constant (E(2)), which ... Read more...
3D-QSAR study of 8-azabicyclo[3.2.1] octane analogs antagonists of cholinergic receptor.
9 Apr 2009 3D-QSAR models of Comparative of Molecular Field Analysis (CoMFA) and Comparative of Molecular Similarities Indices Analysis (CoMSIA) of 20 8-azabicyclo[3.2.1] octane (potent muscarinic receptor blocker) was performed. These benztropine analogs were ... Read more...
Latest indexed articles for 'Receptors, Cholinergic - Chemistry'
These are the very latest articles for this heading:
- Crystal structure of the frizzled-like cysteine-rich domain of the receptor tyrosine kinase MuSK. 2 Aug 2009
- Energy and structure of the M2 helix in acetylcholine receptor-channel gating. 18 May 2009
- 3D-QSAR study of 8-azabicyclo[3.2.1] octane analogs antagonists of cholinergic receptor. 9 Apr 2009
- Redistribution of terbium ions across acetylcholine receptor-enriched membranes induced by agonist desensitization. 6 Apr 2009
- Apparent non-statistical binding in a ditopic receptor for guanosine. 22 Mar 2009
- Aromatic Residues {epsilon}Trp-55 and {delta}Trp-57 and the Activation of Acetylcholine Receptor Channels. 24 Jan 2009
- Physiology and biology of neuromuscular transmission in health and disease. 15 Jan 2009
- Unliganded gating of acetylcholine receptor channels.
27 Dec 2008 - Fetal acetylcholine receptor inactivation syndrome and maternal myasthenia gravis.
7 Dec 2008 - Generating arrays with high content and minimal consumption of functional membrane proteins. 24 Nov 2008
- Optical switches for remote and noninvasive control of cell signaling. 15 Oct 2008
- Polymer-based open-channel blockers for the acetylcholine receptor: the effect of spacer length on blockade kinetics. 7 Aug 2008
- Gating at the mouth of the acetylcholine receptor channel: energetic consequences of mutations in the alphaM2-cap. 23 Jun 2008
- Congenital myasthenia-related AChR delta subunit mutation interferes with intersubunit communication essential for channel gating. 29 Apr 2008
- Fourier transform coupled to tryptophan-scanning mutagenesis: lessons from its application to the prediction of secondary structure in the acetylcholine receptor lipid-exposed transmembrane domains. 18 Feb 2008
- The Ig1/2 domain of MuSK binds to muscle surface and is involved in acetylcholine receptor clustering. 3 Feb 2008
- Recent structural and mechanistic insights into endplate acetylcholine receptors. 30 Dec 2007
- Myasthenia gravis and the tops and bottoms of AChRs: antigenic structure of the MIR and specific immunosuppression of EAMG using AChR cytoplasmic domains. 30 Dec 2007
- An automatic translation of SBML into Beta-binders. 30 Dec 2007
- Acetylcholine receptor gating at extracellular transmembrane domain interface: the cys-loop and M2-M3 linker. 29 Nov 2007
See a longer list of these articles.
Technical information about 'Receptors, Cholinergic'
Definition: Cell surface proteins that bind acetylcholine with high affinity and trigger intracellular changes influencing the behavior of cells. Cholinergic receptors are divided into two major classes, muscarinic and nicotinic, based originally on their affinity for nicotine and muscarine. Each group is further subdivided based on pharmacology, location, mode of action, and/or molecular biology.
Registry Number: 0
Descriptor UI: D011950
Alternative terms: Receptors, Cholinergic; Receptors, Acetylcholine; Cholinoceptive Sites; Sites, Cholinoceptive; Receptors, ACh; Cholinergic Receptors; ACh Receptors; Acetylcholine Receptors; Cholinoceptors;
Allowable Qualifiers: administration & dosage; analysis; biosynthesis; blood; classification; deficiency; drug effects; genetics; history; immunology; isolation & purification; metabolism; physiology; radiation effects; therapeutic use; ultrastructure; chemistry;
Tree Number: D12.776.543.750.720.360;
History Note: 74(71)
Technical Notes: /antag = NEUROMUSCULAR BLOCKING AGENTS or NEUROMUSCULAR DEPOLARIZING AGENTS; coord IM with specific cholinergic agent (IM); DF: RECEPT CHOLINERGIC