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Receptors, Cholinergic - Genetics
Research News and Information
Definition of 'Receptors, Cholinergic'Cell surface proteins that bind acetylcholine with high affinity and trigger intracellular changes influencing the behavior of cells. Cholinergic receptors are divided into two major classes, muscarinic and nicotinic, based originally on their affinity for nicotine and muscarine. Each group is further subdivided based on pharmacology, location, mode of action, and/or molecular biology. Common names: Receptors, Cholinergic; Receptors, Acetylcholine; Cholinoceptive Sites; Sites, Cholinoceptive; Receptors, ACh; Cholinergic Receptors; ACh Receptors; Acetylcholine Receptors; Cholinoceptors |
Sunday, November 22, 2009
30 Jul 2009 
Neuromuscular junction is a prototypical synapse, and most synaptic molecules expressed in the central nervous system have been first identified at the neuromuscular junction. Congenital myasthenic syndromes are caused by genetic defects of ... Read more...
30 Jul 2009 Previous studies have shown increased expression of acetylcholine receptor-alpha (AChR-alpha) subunit transcripts in myasthenia gravis (MG) and experimental MG (EAMG), but none examined the functional properties of this overexpression. In this study ... Read more...
Identification of an agrin mutation that causes congenital myasthenia and affects synapse function.
21 Jul 2009 We report the case of a congenital myasthenic syndrome due to a mutation in AGRN, the gene encoding agrin, an extracellular matrix molecule released by the nerve and critical for formation of the neuromuscular junction. Gene analysis identified a ... Read more...
Latest indexed articles for 'Receptors, Cholinergic - Genetics'
These are the very latest articles for this heading:
- [Molecular bases and therapeutic strategies in defective neuromuscular transmissions: lessons learned from a prototypical synapse] 30 Jul 2009
- Acetylcholine receptor-alpha subunit expression in myasthenia gravis: a role for the autoantigen in pathogenesis? 30 Jul 2009
- Identification of an agrin mutation that causes congenital myasthenia and affects synapse function. 21 Jul 2009
- Myasthenic syndrome due to defects in rapsyn: Clinical and molecular findings in 39 patients. 19 Jul 2009
- Energy and structure of the M2 helix in acetylcholine receptor-channel gating. 18 May 2009
- Silencing rapsyn in vivo decreases acetylcholine receptors and augments sodium channels and secondary postsynaptic membrane folding. 30 Mar 2009
- Novel epsilon subunit mutation of the muscle acetylcholine receptor causing a slow-channel congenital myasthenic syndrome.
30 Mar 2009 - Agrin pathway is controlled by leukemia inhibitory factor (LIF) in murine implantation.
24 Mar 2009 - Genes associated with idiopathic epilepsies: a current overview. 27 Feb 2009
- Aromatic Residues {epsilon}Trp-55 and {delta}Trp-57 and the Activation of Acetylcholine Receptor Channels. 24 Jan 2009
- Cytisine-based nicotinic partial agonists as novel antidepressant compounds. 20 Jan 2009
- A novel role for embigin to promote sprouting of motor nerve terminals at the neuromuscular junction. 19 Jan 2009
- HLA class II allele analysis in MuSK-positive myasthenia gravis suggests a role for DQ5. 11 Jan 2009
- Dynamic expression pattern of distinct genes in the presomitic and somitic mesoderm during Xenopus development. 30 Dec 2008
- Unliganded gating of acetylcholine receptor channels. 27 Dec 2008
- A modified acetylcholine receptor delta-subunit enables a null mutant to survive beyond sexual maturation. Dec 2008
- Increased expression of acetylcholine receptors in the diaphragm muscle of MDX mice. 29 Nov 2008
- Eight genes are required for functional reconstitution of the Caenorhabditis elegans levamisole-sensitive acetylcholine receptor. 17 Nov 2008
- Wnt signaling promotes AChR aggregation at the neuromuscular synapse in collaboration with agrin. 17 Nov 2008
- Tryptophan scanning of the acetylcholine receptor's betaM4 transmembrane domain: decoding allosteric linkage at the lipid-protein interface with ion-channel gating. 4 Nov 2008
See a longer list of these articles.
Technical information about 'Receptors, Cholinergic'
Definition: Cell surface proteins that bind acetylcholine with high affinity and trigger intracellular changes influencing the behavior of cells. Cholinergic receptors are divided into two major classes, muscarinic and nicotinic, based originally on their affinity for nicotine and muscarine. Each group is further subdivided based on pharmacology, location, mode of action, and/or molecular biology.
Registry Number: 0
Descriptor UI: D011950
Alternative terms: Receptors, Cholinergic; Receptors, Acetylcholine; Cholinoceptive Sites; Sites, Cholinoceptive; Receptors, ACh; Cholinergic Receptors; ACh Receptors; Acetylcholine Receptors; Cholinoceptors;
Allowable Qualifiers: administration & dosage; analysis; biosynthesis; blood; classification; deficiency; drug effects; genetics; history; immunology; isolation & purification; metabolism; physiology; radiation effects; therapeutic use; ultrastructure; chemistry;
Tree Number: D12.776.543.750.720.360;
History Note: 74(71)
Technical Notes: /antag = NEUROMUSCULAR BLOCKING AGENTS or NEUROMUSCULAR DEPOLARIZING AGENTS; coord IM with specific cholinergic agent (IM); DF: RECEPT CHOLINERGIC