Receptors, Corticotropin-Releasing Hormone - Antagonists & inhibitors
Research News and Information

Monday, November 23, 2009

Corticotropin-releasing factor receptor antagonism within the dorsal raphe nucleus reduces social anxiety-like behavior after early-life social isolation.

10 Aug 2009 Social isolation of rats during the early part of development increases social anxiety-like behavior in adulthood. Furthermore, early-life social isolation increases the levels of corticotropin-releasing factor (CRF) receptors in the serotonergic ... Read more...

A role for corticotropin-releasing factor in functional gastrointestinal disorders.

30 Jul 2009 Functional gastrointestinal disorders (FGIDs), which include irritable bowel syndrome (IBS), encompass a heterogeneous group of diseases identified by chronic or recurrent symptom-based diagnostic criteria. Psychosocial factors are key components in ... Read more...

Synthesis, structure-activity relationships, and in vivo evaluation of N3-phenylpyrazinones as novel corticotropin-releasing factor-1 (CRF1) receptor antagonists.

21 Jul 2009 Evidence suggests that corticotropin-releasing factor-1 (CRF(1)) receptor antagonists may offer therapeutic potential for the treatment of diseases associated with elevated levels of CRF such as anxiety and depression. A pyrazinone-based chemotype ... Read more...

Latest indexed articles for 'Receptors, Corticotropin-Releasing Hormone - Antagonists & inhibitors'

These are the very latest articles for this heading:

• Corticotropin-releasing factor receptor antagonism within the dorsal raphe nucleus reduces social anxiety-like behavior after early-life social isolation. 10 Aug 2009
• A role for corticotropin-releasing factor in functional gastrointestinal disorders. 30 Jul 2009
• Synthesis, structure-activity relationships, and in vivo evaluation of N3-phenylpyrazinones as novel corticotropin-releasing factor-1 (CRF1) receptor antagonists. 21 Jul 2009
• In vitro intrinsic clearance-based optimization of N3-phenylpyrazinones as corticotropin-releasing factor-1 (CRF1) receptor antagonists. 21 Jul 2009
• Power spectrum analysis of ultrasonic vocalization elicited by maternal separation in rat pups. 9 Jun 2009
• 8-(4-Methoxyphenyl)pyrazolo[1,5-a]-1,3,5-triazines: selective and centrally active corticotropin-releasing factor receptor-1 (CRF1) antagonists. 12 May 2009
• Synthesis and structure-activity relationships of 8-(pyrid-3-yl)pyrazolo[1,5-a]-1,3,5-triazines: potent, orally bioavailable corticotropin releasing factor receptor-1 (CRF1) antagonists. 12 May 2009
• Inhibition of serotonin outflow by nociceptin/orphaninFQ in dorsal raphe nucleus slices from normal and stressed rats: Role of corticotropin releasing factor. 29 Apr 2009
• The effects of apelin on hypothalamic-pituitary-adrenal axis neuroendocrine function are mediated through corticotrophin-releasing factor- and vasopressin-dependent mechanisms. 22 Apr 2009
• Cardiovascular responses to microinjections of urocortins into the NTS: role of inotropic glutamate receptors. 22 Apr 2009
• Findings on alcohol dependence point to promising avenues for targeted therapies. 20 Apr 2009
• Cocaine withdrawal enhances long-term potentiation in rat hippocampus via changing the activity of corticotropin-releasing factor receptor subtype 2. 15 Apr 2009
• Do corticotropin releasing factor-1 receptors influence colonic transit and bowel function in women with irritable bowel syndrome? 31 Mar 2009
• Corticotropin-releasing factor-1 receptor antagonists decrease heroin self-administration in long- but not short-access rats. 30 Mar 2009
• Neuropeptide S reinstates cocaine-seeking behavior and increases locomotor activity through corticotropin-releasing factor receptor 1 in mice. 30 Mar 2009
• Nicotine suppresses energy storage through activation of sympathetic outflow to brown adipose tissue via corticotropin-releasing factor type 1 receptor. 18 Mar 2009
• Cholinergic giant migrating contractions in conscious mouse colon assessed by using a novel noninvasive solid-state manometry method: modulation by stressors. 17 Mar 2009
• Endocrine, behavioral and autonomic effects of neuropeptide AF. 4 Mar 2009
• Effects of acidic-astressin and ovine-CRF microinfusions into the ventral hippocampus on defensive behaviors in rats. 4 Mar 2009
• Reinstatement of cocaine seeking by hypocretin (orexin) in the ventral tegmental area: independence from the local corticotropin-releasing factor network. 26 Feb 2009

See a longer list of these articles.

Technical information about 'Receptors, Corticotropin-Releasing Hormone'

Definition: Cell surface proteins that bind corticotropin-releasing hormone with high affinity and trigger intracellular changes which influence the behavior of cells. The corticotropin releasing-hormone receptors on anterior pituitary cells mediate the stimulation of corticotropin release by hypothalamic corticotropin releasing factor. The physiological consequence of activating corticotropin-releasing hormone receptors on central neurons is not well understood.

Registry Number: 0

Descriptor UI: D018019

Alternative terms: Receptors, Corticotropin-Releasing Hormone; Corticotropin-Releasing Hormone Receptors; Hormone Receptors, Corticotropin-Releasing; Receptors, Corticotropin Releasing Hormone; Corticotropin Releasing-Hormone Receptors; Corticotropin Releasing Hormone Receptors; Receptors, Corticotropin Releasing-Hormone; Releasing-Hormone Receptors, Corticotropin; CRF Receptors; Corticotropin Releasing-Factor Receptors; Corticotropin Releasing Factor Receptors; Receptors, Corticotropin Releasing-Factor; Releasing-Factor Receptors, Corticotropin; Receptors, CRF; CRH Receptor; Receptor, CRH; CRH Receptors; Receptors, CRH; Corticotropin Releasing-Hormone Receptor; Corticotropin Releasing Hormone Receptor; Receptor, Corticotropin Releasing-Hormone; Releasing-Hormone Receptor, Corticotropin; CRF Receptor; Receptor, CRF;

Allowable Qualifiers: administration & dosage; analysis; antagonists & inhibitors; biosynthesis; blood; classification; deficiency; drug effects; genetics; history; immunology; isolation & purification; metabolism; physiology; radiation effects; therapeutic use; ultrastructure; chemistry; agonists;

Tree Number: D12.776.543.750.100.180; D12.776.543.750.720.600.290; D12.776.543.750.750.555.290; D12.776.543.750.750.700.150;

Online Note: use RECEPTORS, CORTICOTROPIN-RELEASING HORMONE (NM) to search CORTICOTROPIN RELEASING HORMONE RECEPTOR 1983-93

History Note: 94; was CORTICOTROPIN RELEASING HORMONE RECEPTOR (NM) 1983-93

Technical Notes: DF: note short X ref