Receptors, Corticotropin-Releasing Hormone - Metabolism
Research News and Information

Monday, November 23, 2009

Central nesfatin-1 reduces dark-phase food intake and gastric emptying in rats: differential role of corticotropin-releasing factor2 receptor.

29 Sep 2009 Nesfatin-1, derived from nucleobindin2, is expressed in the hypothalamus and reported in one study to reduce food intake (FI) in rats. To characterize the central anorexigenic action of nesfatin-1 and whether gastric emptying (GE) is altered, we ... Read more...

Activation of phosphatidylinositol 3-kinase/protein kinase B by corticotropin-releasing factor in human monocytes.

21 Jul 2009 Corticotropin-releasing factor (CRF) exerts proinflammatory effects in peripheral tissues, whereas the intracellular pathways mediating these effects have not been completely characterized yet. We have previously shown that CRF induces nuclear ... Read more...

In vitro intrinsic clearance-based optimization of N3-phenylpyrazinones as corticotropin-releasing factor-1 (CRF1) receptor antagonists.

21 Jul 2009 A series of pyrazinone-based heterocycles was identified as potent and orally active corticotropin-releasing factor-1 (CRF(1)) receptor antagonists. Selected compounds proved efficacious in an anxiety model in rats; however, pharmacokinetic ... Read more...

Latest indexed articles for 'Receptors, Corticotropin-Releasing Hormone - Metabolism'

These are the very latest articles for this heading:

• Central nesfatin-1 reduces dark-phase food intake and gastric emptying in rats: differential role of corticotropin-releasing factor2 receptor. 29 Sep 2009
• Activation of phosphatidylinositol 3-kinase/protein kinase B by corticotropin-releasing factor in human monocytes. 21 Jul 2009
• In vitro intrinsic clearance-based optimization of N3-phenylpyrazinones as corticotropin-releasing factor-1 (CRF1) receptor antagonists. 21 Jul 2009
• Role of corticotropin-releasing hormone and receptor in the pathogenesis of psoriasis. 24 Jun 2009
• Cardiac arrest and cardiopulmonary resuscitation dysregulates the hypothalamic-pituitary-adrenal axis. 22 Jun 2009
• 8-(4-Methoxyphenyl)pyrazolo[1,5-a]-1,3,5-triazines: selective and centrally active corticotropin-releasing factor receptor-1 (CRF1) antagonists. 12 May 2009
• Reduced expression of CRH receptor type 1 in upper segment human myometrium during labour. 10 May 2009
• Activation of corticotropin-releasing factor 2 receptor inhibits Purkinje neuron P-type calcium currents via G(o)alpha-dependent PKC epsilon pathway. 7 May 2009
• Corticotropin-releasing hormone and mast cells in the regulation of mucosal barrier function in the human colon. 29 Apr 2009
• Inhibition of serotonin outflow by nociceptin/orphaninFQ in dorsal raphe nucleus slices from normal and stressed rats: Role of corticotropin releasing factor. 29 Apr 2009
• Cortagine, a CRF1 agonist, induces stresslike alterations of colonic function and visceral hypersensitivity in rodents primarily through peripheral pathways. 28 Apr 2009
• Cardiovascular responses to microinjections of urocortins into the NTS: role of inotropic glutamate receptors. 22 Apr 2009
• Circadian rhythms of basal orexin levels in the hypothalamus are not influenced by an impaired corticotropin-releasing hormone receptor type 1 system. 16 Apr 2009
• Cocaine withdrawal enhances long-term potentiation in rat hippocampus via changing the activity of corticotropin-releasing factor receptor subtype 2. 15 Apr 2009
• Stress-induced redistribution of corticotropin-releasing factor receptor subtypes in the dorsal raphe nucleus. 9 Apr 2009
• Region specific gene expression profile in mouse brain after chronic corticotropin releasing factor receptor 1 activation: the novel role for diazepam binding inhibitor in contextual fear conditioning. 7 Apr 2009
• Suppression of progesterone production by stresscopin/urocortin 3 in cultured human granulosa-lutein cells. 5 Apr 2009
• Social defeat stress activates medial amygdala cells that express type 2 corticotropin-releasing factor receptor mRNA. 5 Apr 2009
• Activation of corticotropin-releasing factor receptor 2 in lateral septum negatively regulates maternal defense. 30 Mar 2009
• Neuropeptide S reinstates cocaine-seeking behavior and increases locomotor activity through corticotropin-releasing factor receptor 1 in mice. 30 Mar 2009

See a longer list of these articles.

Technical information about 'Receptors, Corticotropin-Releasing Hormone'

Definition: Cell surface proteins that bind corticotropin-releasing hormone with high affinity and trigger intracellular changes which influence the behavior of cells. The corticotropin releasing-hormone receptors on anterior pituitary cells mediate the stimulation of corticotropin release by hypothalamic corticotropin releasing factor. The physiological consequence of activating corticotropin-releasing hormone receptors on central neurons is not well understood.

Registry Number: 0

Descriptor UI: D018019

Alternative terms: Receptors, Corticotropin-Releasing Hormone; Corticotropin-Releasing Hormone Receptors; Hormone Receptors, Corticotropin-Releasing; Receptors, Corticotropin Releasing Hormone; Corticotropin Releasing-Hormone Receptors; Corticotropin Releasing Hormone Receptors; Receptors, Corticotropin Releasing-Hormone; Releasing-Hormone Receptors, Corticotropin; CRF Receptors; Corticotropin Releasing-Factor Receptors; Corticotropin Releasing Factor Receptors; Receptors, Corticotropin Releasing-Factor; Releasing-Factor Receptors, Corticotropin; Receptors, CRF; CRH Receptor; Receptor, CRH; CRH Receptors; Receptors, CRH; Corticotropin Releasing-Hormone Receptor; Corticotropin Releasing Hormone Receptor; Receptor, Corticotropin Releasing-Hormone; Releasing-Hormone Receptor, Corticotropin; CRF Receptor; Receptor, CRF;

Allowable Qualifiers: administration & dosage; analysis; antagonists & inhibitors; biosynthesis; blood; classification; deficiency; drug effects; genetics; history; immunology; isolation & purification; metabolism; physiology; radiation effects; therapeutic use; ultrastructure; chemistry; agonists;

Tree Number: D12.776.543.750.100.180; D12.776.543.750.720.600.290; D12.776.543.750.750.555.290; D12.776.543.750.750.700.150;

Online Note: use RECEPTORS, CORTICOTROPIN-RELEASING HORMONE (NM) to search CORTICOTROPIN RELEASING HORMONE RECEPTOR 1983-93

History Note: 94; was CORTICOTROPIN RELEASING HORMONE RECEPTOR (NM) 1983-93

Technical Notes: DF: note short X ref