Receptors, Dopamine D2 - Agonists
Research News and Information

Sunday, November 22, 2009

GPR37 surface expression enhancement via N-terminal truncation or protein-protein interactions.

Nov 2009 GPR37, also known as the parkin-associated endothelin-like receptor (Pael-R), is an orphan G-protein-coupled receptor (GPCR) that exhibits poor plasma membrane expression when expressed in most cell types. We sought to find ways to enhance GPR37 ... Read more...

The dopaminergic stabilizer ASP2314/ACR16 selectively interacts with D2(High) receptors.

29 Sep 2009 Dopaminergic stabilizers are recognized as compounds that can either enhance or antagonize dopamine (DA)-dependent behaviors depending on the prevailing dopaminergic tone. The dopaminergic stabilizer ASP2314 is being tested clinically and has been ... Read more...

Adenosine A2A receptor-antagonist/dopamine D2 receptor-agonist bivalent ligands as pharmacological tools to detect A2A-D2 receptor heteromers.

22 Sep 2009 Adenosine A(2A) (A(2A)R) and dopamine D(2) (D(2)R) receptors mediate the antagonism between adenosinergic and dopaminergic transmission in striatopallidal GABAergic neurons and are pharmacological targets for the treatment of Parkinson's disease. ... Read more...

Latest indexed articles for 'Receptors, Dopamine D2 - Agonists'

These are the very latest articles for this heading:

• GPR37 surface expression enhancement via N-terminal truncation or protein-protein interactions. Nov 2009
• The dopaminergic stabilizer ASP2314/ACR16 selectively interacts with D2(High) receptors. 29 Sep 2009
• Adenosine A2A receptor-antagonist/dopamine D2 receptor-agonist bivalent ligands as pharmacological tools to detect A2A-D2 receptor heteromers. 22 Sep 2009
• R1441C mutation in LRRK2 impairs dopaminergic neurotransmission in mice. 8 Aug 2009
• Dopaminergic modulation of olfactory bulb processing affects odor discrimination learning in rats. 30 Jul 2009
• [A new approach to antischizophrenic therapeutics: D2 dopamine receptor partial agonists] 16 Jul 2009
• Penile erection and yawning induced by dopamine D2-like receptor agonists in rats: influence of strain and contribution of dopamine D2, but not D3 and D4 receptors. 29 Jun 2009
• Single dose of a dopamine agonist impairs reinforcement learning in humans: evidence from event-related potentials and computational modeling of striatal-cortical function. 29 Jun 2009
• Positron emission tomography imaging of D(2/3) agonist binding in healthy human subjects with the radiotracer [(11)C]-N-propyl-norapomorphine: preliminary evaluation and reproducibility studies. 29 Jun 2009
• Antidepressant effects of pramipexole, a dopamine D3/D2 receptor agonist, and 7-OH-DPAT, a dopamine D3 receptor agonist, in olfactory bulbectomized rats. 19 Jun 2009
• Dopaminergic modulation of afferent synaptic transmission in the semicircular canals of frogs. 15 Jun 2009
• 'Click' D(1) receptor agonists with a 5-HT(1A) receptor pharmacophore producing D(2) receptor activity. 14 Jun 2009
• The brain dopaminergic system as an important center regulating liver cytochrome P450 in the rat. 30 May 2009
• Aripiprazole and haloperidol suppress excessive dopamine release in the amygdala in response to conditioned fear stress, but show contrasting effects on basal dopamine release in methamphetamine-sensitized rats. 25 May 2009
• Dose-dependent inverted U-shaped effect of dopamine (D2-like) receptor activation on focal and nonfocal plasticity in humans. 11 May 2009
• Aripiprazole in L-dopa-induced dyskinesias: a one-year open-label pilot study. 10 May 2009
• Using prepulse inhibition to detect functional D3 receptor antagonism: effects of WC10 and WC44. 4 May 2009
• N-Substituted-2-alkyl- and 2-arylnorapomorphines: novel, highly active D2 agonists. May 2009
• Low dose apomorphine induces context-specific sensitization of hypolocomotion without conditioning: support for a new state dependent retrieval hypothesis of drug conditioning and sensitization. May 2009
• Dopamine D(2/3) receptor occupancy of apomorphine in the nonhuman primate brain--a comparative PET study with [11C]raclopride and [11C]MNPA. 29 Apr 2009

See a longer list of these articles.

Technical information about 'Receptors, Dopamine D2'

Definition: A subfamily of G-PROTEIN-COUPLED RECEPTORS that bind the neurotransmitter DOPAMINE and modulate its effects. D2-class receptor genes contain INTRONS, and the receptors inhibit ADENYLATE CYCLASE.

Registry Number: 0

Descriptor UI: D017448

Alternative terms: Receptors, Dopamine D2; Dopamine-D2 Receptor; Dopamine D2 Receptor; Receptor, Dopamine-D2; Dopamine D2 Receptors; D2 Receptors, Dopamine;

Allowable Qualifiers: administration & dosage; analysis; antagonists & inhibitors; biosynthesis; blood; classification; deficiency; drug effects; genetics; history; immunology; isolation & purification; metabolism; physiology; radiation effects; therapeutic use; ultrastructure; chemistry; agonists;

Tree Number: D12.776.543.750.070.300.400.500; D12.776.543.750.100.150.400.500; D12.776.543.750.720.300.300.400.500;

Online Note: use RECEPTORS, DOPAMINE D2 (NM) to search DOPAMINE-D2 RECEPTOR 1982-92

History Note: 93; was DOPAMINE-D2 RECEPTOR (NM) 1982-92

Technical Notes: DF: RECEPT DOPAMINE D2