Receptors, Dopamine D2 - Antagonists & inhibitors
Research News and Information

Saturday, November 21, 2009

GPR37 surface expression enhancement via N-terminal truncation or protein-protein interactions.

Nov 2009 GPR37, also known as the parkin-associated endothelin-like receptor (Pael-R), is an orphan G-protein-coupled receptor (GPCR) that exhibits poor plasma membrane expression when expressed in most cell types. We sought to find ways to enhance GPR37 ... Read more...

NCS-1 in the dentate gyrus promotes exploration, synaptic plasticity, and rapid acquisition of spatial memory.

8 Sep 2009 The molecular underpinnings of exploration and its link to learning and memory remain poorly understood. Here we show that inducible, modest overexpression of neuronal calcium sensor 1 (Ncs1) selectively in the adult murine dentate gyrus (DG) ... Read more...

Neocortical movement representations are reduced and reorganized following bilateral intrastriatal 6-hydroxydopamine infusion and dopamine type-2 receptor antagonism.

20 Aug 2009 The neurophysiologic model of Parkinson's disease predicts nigrostriatal dopamine depletion leads to increased inhibitory basal ganglia output resulting in frontal neocortical hypoactivity. The nature of this hypoactivation is not well understood ... Read more...

Latest indexed articles for 'Receptors, Dopamine D2 - Antagonists & inhibitors'

These are the very latest articles for this heading:

• GPR37 surface expression enhancement via N-terminal truncation or protein-protein interactions. Nov 2009
• NCS-1 in the dentate gyrus promotes exploration, synaptic plasticity, and rapid acquisition of spatial memory. 8 Sep 2009
• Neocortical movement representations are reduced and reorganized following bilateral intrastriatal 6-hydroxydopamine infusion and dopamine type-2 receptor antagonism. 20 Aug 2009
• Allosteric communication between protomers of dopamine class A GPCR dimers modulates activation. 31 Jul 2009
• Dopaminergic modulation of olfactory bulb processing affects odor discrimination learning in rats. 30 Jul 2009
• The 5-HT2 receptor profiles of antipsychotics in the pathogenesis of obsessive-compulsive symptoms in schizophrenia. 29 Jun 2009
• Penile erection and yawning induced by dopamine D2-like receptor agonists in rats: influence of strain and contribution of dopamine D2, but not D3 and D4 receptors. 29 Jun 2009
• Effects of dopamine D1 and D2 receptor antagonists on laryngeal neurophysiology in the rat. 15 Jun 2009
• 'Click' D(1) receptor agonists with a 5-HT(1A) receptor pharmacophore producing D(2) receptor activity. 14 Jun 2009
• Aripiprazole and haloperidol suppress excessive dopamine release in the amygdala in response to conditioned fear stress, but show contrasting effects on basal dopamine release in methamphetamine-sensitized rats. 25 May 2009
• Bifeprunox and aripiprazole suppress in vivo VTA dopaminergic neuronal activity via D2 and not D3 dopamine autoreceptor activation. 16 May 2009
• Control of within-binge cocaine-seeking by dopamine and glutamate in the core of nucleus accumbens. 11 May 2009
• Cue-induced dopamine release predicts cocaine preference: positron emission tomography studies in freely moving rodents. 11 May 2009
• Fluorescent false neurotransmitters visualize dopamine release from individual presynaptic terminals. 5 May 2009
• Using prepulse inhibition to detect functional D3 receptor antagonism: effects of WC10 and WC44. 4 May 2009
• A role for dopamine D2 receptors in reversal learning. May 2009
• Differential effects of dopamine D2 and GABA(A) receptor antagonists on dopamine neurons between the anterior and posterior ventral tegmental area of female Wistar rats. 29 Apr 2009
• Dopamine D(2/3) receptor occupancy of apomorphine in the nonhuman primate brain--a comparative PET study with [11C]raclopride and [11C]MNPA. 29 Apr 2009
• N-(4-(4-(2,3-dichloro- or 2-methoxyphenyl)piperazin-1-yl)butyl)heterobiarylcarboxamides with functionalized linking chains as high affinity and enantioselective D3 receptor antagonists. 21 Apr 2009
• Human biodistribution and dosimetry of the D2/3 agonist 11C-N-propylnorapomorphine (11C-NPA) determined from PET. 14 Apr 2009

See a longer list of these articles.

Technical information about 'Receptors, Dopamine D2'

Definition: A subfamily of G-PROTEIN-COUPLED RECEPTORS that bind the neurotransmitter DOPAMINE and modulate its effects. D2-class receptor genes contain INTRONS, and the receptors inhibit ADENYLATE CYCLASE.

Registry Number: 0

Descriptor UI: D017448

Alternative terms: Receptors, Dopamine D2; Dopamine-D2 Receptor; Dopamine D2 Receptor; Receptor, Dopamine-D2; Dopamine D2 Receptors; D2 Receptors, Dopamine;

Allowable Qualifiers: administration & dosage; analysis; antagonists & inhibitors; biosynthesis; blood; classification; deficiency; drug effects; genetics; history; immunology; isolation & purification; metabolism; physiology; radiation effects; therapeutic use; ultrastructure; chemistry; agonists;

Tree Number: D12.776.543.750.070.300.400.500; D12.776.543.750.100.150.400.500; D12.776.543.750.720.300.300.400.500;

Online Note: use RECEPTORS, DOPAMINE D2 (NM) to search DOPAMINE-D2 RECEPTOR 1982-92

History Note: 93; was DOPAMINE-D2 RECEPTOR (NM) 1982-92

Technical Notes: DF: RECEPT DOPAMINE D2