Receptors, Dopamine D2 - Deficiency
Research News and Information

Sunday, November 22, 2009

Dopamine D2 receptor knockout mice develop features of Parkinson disease.

29 Sep 2009 OBJECTIVE: This study questions whether increased dopamine (DA) turnover in nigral neurons leads to formation of Lewy bodies (LBs), the characteristic alpha-synuclein-containing cytoplasmic inclusion of Parkinson disease (PD). METHODS: Mice with ... Read more...

Genetic inactivation of dopamine D1 but not D2 receptors inhibits L-DOPA-induced dyskinesia and histone activation.

9 Jun 2009 BACKGROUND: Pharmacologic studies have implicated dopamine D1-like receptors in the development of dopamine precursor molecule 3,4-dihydroxyphenyl-L-alanine (L-DOPA)-induced dyskinesias and associated molecular changes in hemiparkinsonian mice. ... Read more...

D2R striatopallidal neurons inhibit both locomotor and drug reward processes.

6 Mar 2009 The specific functions of dopamine D(2) receptor-positive (D(2)R) striatopallidal neurons remain poorly understood. Using a genetic mouse model, we found that ablation of D(2)R neurons in the entire striatum induced hyperlocomotion, whereas ablation ... Read more...

Latest indexed articles for 'Receptors, Dopamine D2 - Deficiency'

These are the very latest articles for this heading:

• Dopamine D2 receptor knockout mice develop features of Parkinson disease. 29 Sep 2009
• Genetic inactivation of dopamine D1 but not D2 receptors inhibits L-DOPA-induced dyskinesia and histone activation. 9 Jun 2009
• D2R striatopallidal neurons inhibit both locomotor and drug reward processes. 6 Mar 2009
• GABA(A) receptors mediate the opposing roles of dopamine and the tegmental pedunculopontine nucleus in the motivational effects of ethanol. 27 Feb 2009
• Genetically determined interaction between the dopamine transporter and the D2 receptor on prefronto-striatal activity and volume in humans. 26 Jan 2009
• Enhanced latent inhibition in dopamine receptor-deficient mice is sex-specific for the D1 but not D2 receptor subtype: implications for antipsychotic drug action. 15 Nov 2008
• Emotional response in dopamine D2L receptor-deficient mice. 16 Sep 2008
• Dopaminergic D1 and D2 receptors are essential for the arousal effect of modafinil. 18 Aug 2008
• Hyperthermic and lethal effects of methamphetamine: roles of dopamine D1 and D2 receptors. 14 Apr 2008
• Dopamine regulates endothelial progenitor cell mobilization from mouse bone marrow in tumor vascularization. 30 Mar 2008
• Adaptive changes in the expression of central opioid receptors in mice lacking the dopamine D2 receptor gene. 16 Mar 2008
• Dopamine gene predicts the brain's response to dopaminergic drug. 29 Nov 2007
• Fibroblast growth factor-2 in hyperplastic pituitaries of D2R knockout female mice. 9 Sep 2007
• Hypoxia transduction by carotid body chemoreceptors in mice lacking dopamine D(2) receptors. 31 Jul 2007
• Absence of dopamine D2 receptors unmasks an inhibitory control over the brain circuitries activated by cocaine. 8 Apr 2007
• Role of dopamine D1 and D2 receptors in CRF-induced disruption of sensorimotor gating. 29 Jan 2007
• D1-D2 dopamine receptor heterooligomers with unique pharmacology are coupled to rapid activation of Gq/11 in the striatum. 26 Dec 2006
• Differential contributions of dopamine D1, D2, and D3 receptors to MDMA-induced effects on locomotor behavior patterns in mice. 17 Jul 2006
• Physiological modulation of intestinal motility by enteric dopaminergic neurons and the D2 receptor: analysis of dopamine receptor expression, location, development, and function in wild-type and knock-out mice. 6 Mar 2006
• Dopamine D2 receptors mediate reversal learning in male C57BL/6J mice. 27 Feb 2006

See a longer list of these articles.

Technical information about 'Receptors, Dopamine D2'

Definition: A subfamily of G-PROTEIN-COUPLED RECEPTORS that bind the neurotransmitter DOPAMINE and modulate its effects. D2-class receptor genes contain INTRONS, and the receptors inhibit ADENYLATE CYCLASE.

Registry Number: 0

Descriptor UI: D017448

Alternative terms: Receptors, Dopamine D2; Dopamine-D2 Receptor; Dopamine D2 Receptor; Receptor, Dopamine-D2; Dopamine D2 Receptors; D2 Receptors, Dopamine;

Allowable Qualifiers: administration & dosage; analysis; antagonists & inhibitors; biosynthesis; blood; classification; deficiency; drug effects; genetics; history; immunology; isolation & purification; metabolism; physiology; radiation effects; therapeutic use; ultrastructure; chemistry; agonists;

Tree Number: D12.776.543.750.070.300.400.500; D12.776.543.750.100.150.400.500; D12.776.543.750.720.300.300.400.500;

Online Note: use RECEPTORS, DOPAMINE D2 (NM) to search DOPAMINE-D2 RECEPTOR 1982-92

History Note: 93; was DOPAMINE-D2 RECEPTOR (NM) 1982-92

Technical Notes: DF: RECEPT DOPAMINE D2