Receptors, Dopamine D2 - Metabolism
Research News and Information

Monday, November 23, 2009

GPR37 surface expression enhancement via N-terminal truncation or protein-protein interactions.

Nov 2009 GPR37, also known as the parkin-associated endothelin-like receptor (Pael-R), is an orphan G-protein-coupled receptor (GPCR) that exhibits poor plasma membrane expression when expressed in most cell types. We sought to find ways to enhance GPR37 ... Read more...

Ex vivo [11C]-(+)-PHNO binding is unchanged in animal models displaying increased high-affinity states of the D2 receptor in vitro.

30 Oct 2009 Dopamine (DA) D2 receptor supersensitivity has been linked to an increase in the density of the D2 high-affinity state as measured in vitro. The two- affinity-state model of the D2 receptor predicts that the ex vivo specific binding of ... Read more...

Glutamate agonist LY404,039 for treating schizophrenia has affinity for the dopamine D2(High) receptor.

29 Sep 2009 The glutamate agonist LY404,039 has been used to treat schizophrenia. Because all currently used antipsychotics act on dopamine receptors, it was decided to examine whether this glutamate agonist also had an affinity for dopamine D2 receptors in ... Read more...

Latest indexed articles for 'Receptors, Dopamine D2 - Metabolism'

These are the very latest articles for this heading:

• GPR37 surface expression enhancement via N-terminal truncation or protein-protein interactions. Nov 2009
• Ex vivo [11C]-(+)-PHNO binding is unchanged in animal models displaying increased high-affinity states of the D2 receptor in vitro. 30 Oct 2009
• Glutamate agonist LY404,039 for treating schizophrenia has affinity for the dopamine D2(High) receptor. 29 Sep 2009
• The dopaminergic stabilizer ASP2314/ACR16 selectively interacts with D2(High) receptors. 29 Sep 2009
• C957T polymorphism of dopamine D2 receptor gene affects striatal DRD2 in vivo availability by changing the receptor affinity. 29 Sep 2009
• Time-dependent exposure of nicotine and smoke modulate ultrasubcellular organelle localization of dopamine D1 and D2 receptors in the rat caudate-putamen. 29 Sep 2009
• Neuroimaging placebo effects: new tools generate new questions. 29 Sep 2009
• Adenosine A2A receptor-antagonist/dopamine D2 receptor-agonist bivalent ligands as pharmacological tools to detect A2A-D2 receptor heteromers. 22 Sep 2009
• NCS-1 in the dentate gyrus promotes exploration, synaptic plasticity, and rapid acquisition of spatial memory. 8 Sep 2009
• Evaluating dopamine reward pathway in ADHD: clinical implications. 7 Sep 2009
• Aripiprazole: dose-response relationship in schizophrenia and schizoaffective disorder. 30 Aug 2009
• Lower level of endogenous dopamine in patients with cocaine dependence: findings from PET imaging of D(2)/D(3) receptors following acute dopamine depletion. 30 Aug 2009
• Laterality of cortical response to ethanol is moderated by TaqIA A1 allele. 30 Aug 2009
• In vivo quantification of regional dopamine-D3 receptor binding potential of (+)-PHNO: Studies in non-human primates and transgenic mice. 30 Aug 2009
• Dopaminergic response to graded dopamine concentration elicited by four amphetamine doses. 30 Aug 2009
• Dopamine release at individual presynaptic terminals visualized with FFNs. 29 Aug 2009
• Neocortical movement representations are reduced and reorganized following bilateral intrastriatal 6-hydroxydopamine infusion and dopamine type-2 receptor antagonism. 20 Aug 2009
• [Neurobiological and pharmacologic aspects of atypical antipsychotic drugs] 14 Aug 2009
• Dopamine D2, D3, and D4 selective phenylpiperazines as molecular probes to explore the origins of subtype specific receptor binding. 11 Aug 2009
• Allosteric communication between protomers of dopamine class A GPCR dimers modulates activation. 31 Jul 2009

See a longer list of these articles.

Technical information about 'Receptors, Dopamine D2'

Definition: A subfamily of G-PROTEIN-COUPLED RECEPTORS that bind the neurotransmitter DOPAMINE and modulate its effects. D2-class receptor genes contain INTRONS, and the receptors inhibit ADENYLATE CYCLASE.

Registry Number: 0

Descriptor UI: D017448

Alternative terms: Receptors, Dopamine D2; Dopamine-D2 Receptor; Dopamine D2 Receptor; Receptor, Dopamine-D2; Dopamine D2 Receptors; D2 Receptors, Dopamine;

Allowable Qualifiers: administration & dosage; analysis; antagonists & inhibitors; biosynthesis; blood; classification; deficiency; drug effects; genetics; history; immunology; isolation & purification; metabolism; physiology; radiation effects; therapeutic use; ultrastructure; chemistry; agonists;

Tree Number: D12.776.543.750.070.300.400.500; D12.776.543.750.100.150.400.500; D12.776.543.750.720.300.300.400.500;

Online Note: use RECEPTORS, DOPAMINE D2 (NM) to search DOPAMINE-D2 RECEPTOR 1982-92

History Note: 93; was DOPAMINE-D2 RECEPTOR (NM) 1982-92

Technical Notes: DF: RECEPT DOPAMINE D2