Receptors, Dopamine D3 - Antagonists & inhibitors
Research News and Information

Monday, November 23, 2009

Acute neurobehavioral effects of toluene: involvement of dopamine and NMDA receptors.

14 Sep 2009 Toluene, a widely used and commonly abused organic solvent, causes a variety of behavioral disturbances in both humans and animals. In this study, the effects of toluene on locomotor activity, motor coordination, and passive avoidance learning, ... Read more...

The 5-HT2 receptor profiles of antipsychotics in the pathogenesis of obsessive-compulsive symptoms in schizophrenia.

29 Jun 2009 Atypical antipsychotics have been reported to induce or exacerbate obsessive-compulsive symptoms (OCS) in patients with schizophrenia. We report the development of de novo obsession induced by sequential treatment with risperidone, aripiprazole, and ... Read more...

Predictability of intranasal pharmacokinetics in man using pre-clinical pharmacokinetic data with a dopamine 3 receptor agonist, PF-219061.

29 Jun 2009 (R)-3-(4-propylmorpholin-2-yl) phenol (PF-219061) is a potent, selective agonist of the dopamine 3 receptor for the treatment of female sexual dysfunction. In vivo, PF-219061 exhibits liver blood flow clearance in both rat and dog. Oral ... Read more...

Latest indexed articles for 'Receptors, Dopamine D3 - Antagonists & inhibitors'

These are the very latest articles for this heading:

• Acute neurobehavioral effects of toluene: involvement of dopamine and NMDA receptors. 14 Sep 2009
• The 5-HT2 receptor profiles of antipsychotics in the pathogenesis of obsessive-compulsive symptoms in schizophrenia. 29 Jun 2009
• Predictability of intranasal pharmacokinetics in man using pre-clinical pharmacokinetic data with a dopamine 3 receptor agonist, PF-219061. 29 Jun 2009
• Penile erection and yawning induced by dopamine D2-like receptor agonists in rats: influence of strain and contribution of dopamine D2, but not D3 and D4 receptors. 29 Jun 2009
• Dopamine D3 receptor antagonists: the quest for a potentially selective PET ligand. Part one: lead identification. 12 Jun 2009
• Bifeprunox and aripiprazole suppress in vivo VTA dopaminergic neuronal activity via D2 and not D3 dopamine autoreceptor activation. 16 May 2009
• Using prepulse inhibition to detect functional D3 receptor antagonism: effects of WC10 and WC44. 4 May 2009
• Dopamine D(2/3) receptor occupancy of apomorphine in the nonhuman primate brain--a comparative PET study with [11C]raclopride and [11C]MNPA. 29 Apr 2009
• D3 dopamine receptor regulation of ETB receptors in renal proximal tubule cells from WKY and SHRs. 21 Apr 2009
• N-(4-(4-(2,3-dichloro- or 2-methoxyphenyl)piperazin-1-yl)butyl)heterobiarylcarboxamides with functionalized linking chains as high affinity and enantioselective D3 receptor antagonists. 21 Apr 2009
• Human biodistribution and dosimetry of the D2/3 agonist 11C-N-propylnorapomorphine (11C-NPA) determined from PET. 14 Apr 2009
• Pharmacological analysis demonstrates dramatic alteration of D1 dopamine receptor neuronal distribution in the rat analog of L-DOPA-induced dyskinesia. 13 Apr 2009
• Amisulpride treatment for clozapine-induced sialorrhea. 30 Mar 2009
• Dopamine modulates effort-based decision making in rats. 30 Mar 2009
• The preferential dopamine D3 receptor antagonist S33138 inhibits cocaine reward and cocaine-triggered relapse to drug-seeking behavior in rats. 27 Feb 2009
• Evaluation of the D3 dopamine receptor selective antagonist PG01037 on L-dopa-dependent abnormal involuntary movements in rats. 3 Feb 2009
• Evaluation of D2 and D3 dopamine receptor selective compounds on L-dopa-dependent abnormal involuntary movements in rats. 3 Feb 2009
• Proerectile effects of dopamine D2-like agonists are mediated by the D3 receptor in rats and mice. 7 Jan 2009
• Mechanisms underlying psychosis and antipsychotic treatment response in schizophrenia: insights from PET and SPECT imaging. 30 Dec 2008
• Dopamine D3 receptor stimulation underlies the development of L-DOPA-induced dyskinesia in animal models of Parkinson's disease. 7 Dec 2008

See a longer list of these articles.

Technical information about 'Receptors, Dopamine D3'

Definition: A subtype of dopamine D2 receptors that are highly expressed in the LIMBIC SYSTEM of the brain.

Registry Number: 0

Descriptor UI: D050637

Alternative terms: Receptors, Dopamine D3; D3 Receptors, Dopamine; Dopamine D3 Receptors; Receptor, Dopamine-D3; Dopamine-D3 Receptor; Dopamine D3 Receptor; D3 Receptor, Dopamine; Receptor, Dopamine D3;

Allowable Qualifiers: administration & dosage; analysis; antagonists & inhibitors; biosynthesis; blood; classification; deficiency; drug effects; genetics; history; immunology; isolation & purification; metabolism; physiology; radiation effects; therapeutic use; ultrastructure; chemistry; agonists;

Tree Number: D12.776.543.750.070.300.400.500.249; D12.776.543.750.100.150.400.500.500; D12.776.543.750.720.300.300.400.500.249;

History Note: 2006(1987)

Technical Notes: see SCR for organism-specific terms