Receptors, Dopamine D3
Research News and Information

Sunday, November 22, 2009

Critical review of ropinirole and pramipexole - putative dopamine D(3)-receptor selective agonists - for the treatment of RLS.

29 Sep 2009 Ropinirole hydrochloride (REQUIP, ADARTREL) and pramipexole dihydrochloride (MIRAPEX, SIFROL) are two putative dopamine D(3) receptor subtype-selective agonists recently approved by the FDA for the treatment of 'restless legs syndrome' (RLS). RLS is ... Read more...

Acute neurobehavioral effects of toluene: involvement of dopamine and NMDA receptors.

14 Sep 2009 Toluene, a widely used and commonly abused organic solvent, causes a variety of behavioral disturbances in both humans and animals. In this study, the effects of toluene on locomotor activity, motor coordination, and passive avoidance learning, ... Read more...

Lower level of endogenous dopamine in patients with cocaine dependence: findings from PET imaging of D(2)/D(3) receptors following acute dopamine depletion.

30 Aug 2009 OBJECTIVE: Previous positron emission tomography (PET) imaging studies have demonstrated that cocaine dependence is associated with a decrease in dopamine type 2 and 3 (D(2)/D(3)) receptor binding in cocaine-dependent individuals relative to healthy ... Read more...

Latest indexed articles for 'Receptors, Dopamine D3'

These are the very latest articles for this heading:

• Critical review of ropinirole and pramipexole - putative dopamine D(3)-receptor selective agonists - for the treatment of RLS. 29 Sep 2009
• Acute neurobehavioral effects of toluene: involvement of dopamine and NMDA receptors. 14 Sep 2009
• Lower level of endogenous dopamine in patients with cocaine dependence: findings from PET imaging of D(2)/D(3) receptors following acute dopamine depletion. 30 Aug 2009
• In vivo quantification of regional dopamine-D3 receptor binding potential of (+)-PHNO: Studies in non-human primates and transgenic mice. 30 Aug 2009
• [(3)H]4-(Dimethylamino)-N-[4-(4-(2-methoxyphenyl)piperazin- 1-yl)butyl]benzamide, a selective radioligand for dopamine D(3) receptors. I. In vitro characterization. 30 Aug 2009
• Hypoxia-induced transcription of dopamine D3 and D4 receptors in human neuroblastoma and astrocytoma cells. 2 Aug 2009
• Glutamate agonists for treating schizophrenia have affinity for dopamine D2High and D3 receptors. 30 Jul 2009
• No association between lithium full responders and the DRD1, DRD2, DRD3, DAT1, 5-HTTLPR and HTR2A genes in a Sardinian sample. 29 Jul 2009
• Dopamine receptor activation promotes adult neurogenesis in an acute Parkinson model. 16 Jul 2009
• The 5-HT2 receptor profiles of antipsychotics in the pathogenesis of obsessive-compulsive symptoms in schizophrenia. 29 Jun 2009
• Predictability of intranasal pharmacokinetics in man using pre-clinical pharmacokinetic data with a dopamine 3 receptor agonist, PF-219061. 29 Jun 2009
• Penile erection and yawning induced by dopamine D2-like receptor agonists in rats: influence of strain and contribution of dopamine D2, but not D3 and D4 receptors. 29 Jun 2009
• Single dose of a dopamine agonist impairs reinforcement learning in humans: evidence from event-related potentials and computational modeling of striatal-cortical function. 29 Jun 2009
• Positron emission tomography imaging of D(2/3) agonist binding in healthy human subjects with the radiotracer [(11)C]-N-propyl-norapomorphine: preliminary evaluation and reproducibility studies. 29 Jun 2009
• Dopamine signaling is required for depolarization-induced slow current in cerebellar Purkinje cells. 29 Jun 2009
• Parallel synthesis of potent dopaminergic N-phenyltriazole carboxamides applying a novel click chemistry based phenol linker. 23 Jun 2009
• Antidepressant effects of pramipexole, a dopamine D3/D2 receptor agonist, and 7-OH-DPAT, a dopamine D3 receptor agonist, in olfactory bulbectomized rats. 19 Jun 2009
• Dopamine D3 receptor antagonists: the quest for a potentially selective PET ligand. Part one: lead identification. 12 Jun 2009
• DRD3 Ser9Gly and HS1BP3 Ala265Gly are not associated with Parkinson disease. 10 Jun 2009
• G protein-coupled receptor kinase 4 (GRK4) regulates the phosphorylation and function of the dopamine D3 receptor. 9 Jun 2009

See a longer list of these articles.

Technical information about 'Receptors, Dopamine D3'

Definition: A subtype of dopamine D2 receptors that are highly expressed in the LIMBIC SYSTEM of the brain.

Registry Number: 0

Descriptor UI: D050637

Alternative terms: Receptors, Dopamine D3; D3 Receptors, Dopamine; Dopamine D3 Receptors; Receptor, Dopamine-D3; Dopamine-D3 Receptor; Dopamine D3 Receptor; D3 Receptor, Dopamine; Receptor, Dopamine D3;

Allowable Qualifiers: administration & dosage; analysis; antagonists & inhibitors; biosynthesis; blood; classification; deficiency; drug effects; genetics; history; immunology; isolation & purification; metabolism; physiology; radiation effects; therapeutic use; ultrastructure; chemistry; agonists;

Tree Number: D12.776.543.750.070.300.400.500.249; D12.776.543.750.100.150.400.500.500; D12.776.543.750.720.300.300.400.500.249;

History Note: 2006(1987)

Technical Notes: see SCR for organism-specific terms