Receptors, Dopamine D4 - Agonists
Research News and Information

Sunday, November 22, 2009

Penile erection and yawning induced by dopamine D2-like receptor agonists in rats: influence of strain and contribution of dopamine D2, but not D3 and D4 receptors.

29 Jun 2009 Dopamine (DA) is implicated in penile erection (PE) and yawning (YA) in rats through activation of D2-like receptors. However, the exact role of each subtype (D2, D3 and D4) of this receptor family in PE/YA is still not clearly elucidated. We ... Read more...

Three amino acids in the D2 dopamine receptor regulate selective ligand function and affinity.

14 Apr 2009 The D(2) dopamine receptor is an important therapeutic target for the treatment of psychotic, agitated, and abnormal behavioral states. To better understand the specific interactions of subtype-selective ligands with dopamine receptor subtypes, ... Read more...

Dopamine D1 versus D4 receptors differentially modulate the encoding of salient versus nonsalient emotional information in the medial prefrontal cortex.

13 Apr 2009 Dopamine (DA) transmission plays a critical role in the processing of emotionally salient information and in associative learning and memory processes. Within the mammalian brain, neurons within the medial prefrontal cortex (mPFC) are involved ... Read more...

Latest indexed articles for 'Receptors, Dopamine D4 - Agonists'

These are the very latest articles for this heading:

• Penile erection and yawning induced by dopamine D2-like receptor agonists in rats: influence of strain and contribution of dopamine D2, but not D3 and D4 receptors. 29 Jun 2009
• Three amino acids in the D2 dopamine receptor regulate selective ligand function and affinity. 14 Apr 2009
• Dopamine D1 versus D4 receptors differentially modulate the encoding of salient versus nonsalient emotional information in the medial prefrontal cortex. 13 Apr 2009
• The azulene framework as a novel arene bioisostere: design of potent dopamine D4 receptor ligands inducing penile erection. 27 Feb 2009
• WAY 100635 produces discriminative stimulus effects in rats mediated by dopamine D(4) receptor activation. 30 Jan 2009
• Proerectile effects of dopamine D2-like agonists are mediated by the D3 receptor in rats and mice. 7 Jan 2009
• Selective dopamine D4 receptor agonist (A-412997) improves cognitive performance and stimulates motor activity without influencing reward-related behaviour in rat. 29 Nov 2008
• Activation of G proteins and extracellular signal-regulated kinase 1/2 phosphorylation via human dopamine D4.4 receptors: differential pathway-dependent potencies of receptor agonists. 4 Aug 2008
• Dopaminergic modulation of risk-based decision making. 28 Jul 2008
• Differential voltage-sensitivity of D2-like dopamine receptors. 20 Jul 2008
• Dopamine D4 receptor involvement in the discriminative stimulus effects in rats of LSD, but not the phenethylamine hallucinogen DOI. 4 Jul 2008
• Dopamine/serotonin receptor ligands. 16.(1) Expanding dibenz[d,g]azecines to 11- and 12-membered homologues. Interaction with dopamine D(1)-D(5) receptors. 2 Aug 2007
• WAY-100635 has high selectivity for serotonin 5-HT(1A) versus dopamine D(4) receptors. 11 Jul 2007
• F15063, a potential antipsychotic with dopamine D(2)/D(3) antagonist, 5-HT(1A) agonist and D(4) partial agonist properties: (IV) duration of brain D2-like receptor occupancy and antipsychotic-like activity versus plasma concentration in mice. 22 Apr 2007
• F15063, a compound with D2/D3 antagonist, 5-HT 1A agonist and D4 partial agonist properties. II. Activity in models of positive symptoms of schizophrenia. 18 Mar 2007
• F15063, a compound with D2/D3 antagonist, 5-HT 1A agonist and D4 partial agonist properties. III. Activity in models of cognition and negative symptoms. 18 Mar 2007
• Dopaminergic regulation of inhibitory and excitatory transmission in the basolateral amygdala-prefrontal cortical pathway. 19 Feb 2007
• Acute clozapine suppresses synchronized pyramidal synaptic network activity by increasing inhibition in the ferret prefrontal cortex. 18 Dec 2006
• Discovery of 3-methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-[2,4'-bipyridine]-1'-ylmethyl)benzamide (ABT-670), an orally bioavailable dopamine D4 agonist for the treatment of erectile dysfunction. 12 Dec 2006
• PIP3EA and PD-168077, two selective dopamine D4 receptor agonists, induce penile erection in male rats: site and mechanism of action in the brain. 29 Sep 2006

See a longer list of these articles.

Technical information about 'Receptors, Dopamine D4'

Definition: A subtype of dopamine D2 receptors that has high affinity for the antipsychotic CLOZAPINE.

Registry Number: 137750-34-6

Descriptor UI: D050638

Alternative terms: Receptors, Dopamine D4; D4 Receptors, Dopamine; Dopamine D4 Receptors; Receptor, Dopamine D4; Dopamine D4 Receptor; D4 Receptor, Dopamine;

Allowable Qualifiers: deficiency; drug effects; genetics; history; immunology; isolation & purification; metabolism; physiology; radiation effects; therapeutic use; ultrastructure; chemistry; agonists; administration & dosage; analysis; antagonists & inhibitors; biosynthesis; blood; classification;

Tree Number: D12.776.543.750.070.300.400.500.500; D12.776.543.750.100.150.400.500.750; D12.776.543.750.720.300.300.400.500.500;

History Note: 2006(1991)

Technical Notes: see SCR for organism-specific terms