Receptors, Dopamine D4 - Antagonists & inhibitors
Research News and Information

Monday, November 23, 2009

Penile erection and yawning induced by dopamine D2-like receptor agonists in rats: influence of strain and contribution of dopamine D2, but not D3 and D4 receptors.

29 Jun 2009 Dopamine (DA) is implicated in penile erection (PE) and yawning (YA) in rats through activation of D2-like receptors. However, the exact role of each subtype (D2, D3 and D4) of this receptor family in PE/YA is still not clearly elucidated. We ... Read more...

N-(4-(4-(2,3-dichloro- or 2-methoxyphenyl)piperazin-1-yl)butyl)heterobiarylcarboxamides with functionalized linking chains as high affinity and enantioselective D3 receptor antagonists.

21 Apr 2009 In the present report, the D3 receptor pharmacophore is modified in the 2,3-diCl- and 2-OCH(3)-phenylpiperazine class of compounds with the goal to improve D3 receptor affinity and selectivity. This extension of structure-activity relationships ... Read more...

Dopamine D1 versus D4 receptors differentially modulate the encoding of salient versus nonsalient emotional information in the medial prefrontal cortex.

13 Apr 2009 Dopamine (DA) transmission plays a critical role in the processing of emotionally salient information and in associative learning and memory processes. Within the mammalian brain, neurons within the medial prefrontal cortex (mPFC) are involved ... Read more...

Latest indexed articles for 'Receptors, Dopamine D4 - Antagonists & inhibitors'

These are the very latest articles for this heading:

• Penile erection and yawning induced by dopamine D2-like receptor agonists in rats: influence of strain and contribution of dopamine D2, but not D3 and D4 receptors. 29 Jun 2009
• N-(4-(4-(2,3-dichloro- or 2-methoxyphenyl)piperazin-1-yl)butyl)heterobiarylcarboxamides with functionalized linking chains as high affinity and enantioselective D3 receptor antagonists. 21 Apr 2009
• Dopamine D1 versus D4 receptors differentially modulate the encoding of salient versus nonsalient emotional information in the medial prefrontal cortex. 13 Apr 2009
• WAY 100635 produces discriminative stimulus effects in rats mediated by dopamine D(4) receptor activation. 30 Jan 2009
• Essential roles of dopamine D4 receptors and the type 1 adenylyl cyclase in photic control of cyclic AMP in photoreceptor cells. 20 Jan 2009
• Proerectile effects of dopamine D2-like agonists are mediated by the D3 receptor in rats and mice. 7 Jan 2009
• Dopamine D4 receptor antagonist L745,870 abolishes cognitive effects of intracerebroventricular angiotensin IV and des-Phe(6)-Ang IV in rats. 3 Oct 2008
• Activation of G proteins and extracellular signal-regulated kinase 1/2 phosphorylation via human dopamine D4.4 receptors: differential pathway-dependent potencies of receptor agonists. 4 Aug 2008
• Dopaminergic modulation of risk-based decision making. 28 Jul 2008
• Dopamine D4 receptor involvement in the discriminative stimulus effects in rats of LSD, but not the phenethylamine hallucinogen DOI. 4 Jul 2008
• Dopamine/serotonin receptor ligands. 16.(1) Expanding dibenz[d,g]azecines to 11- and 12-membered homologues. Interaction with dopamine D(1)-D(5) receptors. 2 Aug 2007
• Lu 35-138 ((+)-(S)-3-{1-[2-(1-acetyl-2,3-dihydro-1H-indol-3-yl)ethyl]-3,6-dihydro-2H-pyridin-4-yl}-6-chloro-1H-indole), a dopamine D4 receptor antagonist and serotonin reuptake inhibitor: characterisation of its in vitro profile and pre-clinical antipsychotic potential. 2 Jul 2007
• Effects of clozapine and sulpiride on morphine state-dependent memory in the step-down passive avoidance test. 19 Dec 2006
• Dopamine/serotonin receptor ligands. 13: Homologization of a benzindoloazecine-type dopamine receptor antagonist modulates the affinities for dopamine D(1)-D(5) receptors. 17 Oct 2006
• 2-[(4-phenylpiperazin-1-yl)methyl]imidazo(di)azines as selective D4-ligands. Induction of penile erection by 2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]imidazo[1,2-a]pyridine (PIP3EA), a potent and selective D4 partial agonist. 27 Jun 2006
• Prefrontal dopamine D4 receptors are involved in encoding fear extinction. 27 May 2006
• Effects of selective dopamine D4 receptor antagonist, L-741,741, on sleep and wakefulness in the rat. 31 Jan 2006
• Dopamine D1 and D4 receptor subtypes differentially modulate recurrent excitatory synapses in prefrontal cortical pyramidal neurons. 30 Jan 2006
• Tissue distribution of radioiodinated FAUC113: assessment of a pyrazolo(1,5-a) pyridine based dopamine D4 receptor radioligand candidate. 30 Dec 2005
• Dopamine D4 receptor signaling in the rat paraventricular hypothalamic nucleus: Evidence of natural coupling involving immediate early gene induction and mitogen activated protein kinase phosphorylation. 29 Nov 2005

See a longer list of these articles.

Technical information about 'Receptors, Dopamine D4'

Definition: A subtype of dopamine D2 receptors that has high affinity for the antipsychotic CLOZAPINE.

Registry Number: 137750-34-6

Descriptor UI: D050638

Alternative terms: Receptors, Dopamine D4; D4 Receptors, Dopamine; Dopamine D4 Receptors; Receptor, Dopamine D4; Dopamine D4 Receptor; D4 Receptor, Dopamine;

Allowable Qualifiers: deficiency; drug effects; genetics; history; immunology; isolation & purification; metabolism; physiology; radiation effects; therapeutic use; ultrastructure; chemistry; agonists; administration & dosage; analysis; antagonists & inhibitors; biosynthesis; blood; classification;

Tree Number: D12.776.543.750.070.300.400.500.500; D12.776.543.750.100.150.400.500.750; D12.776.543.750.720.300.300.400.500.500;

History Note: 2006(1991)

Technical Notes: see SCR for organism-specific terms