Receptors, Dopamine D4
Research News and Information

Sunday, November 22, 2009

Reward-seeking and discrimination deficits displayed by hypodopaminergic mice are prevented in mice lacking dopamine D4 receptors.

30 Oct 2009 The dopamine D4 receptor (D4R) is predominantly expressed in the prefrontal cortex, a brain area that integrates motor, rewarding, and cognitive information. Because participation of D4Rs in executive learning is largely unknown, we challenged D4R ... Read more...

Dopamine D2, D3, and D4 selective phenylpiperazines as molecular probes to explore the origins of subtype specific receptor binding.

11 Aug 2009 Assembling phenylpiperazines with 7a-azaindole via different spacer elements, we developed subtype selective dopamine receptor ligands of types 1a,c, 2a, and 3a preferentially interacting with D4, D2, and D3, respectively. To complete this set, the ... Read more...

Hypoxia-induced transcription of dopamine D3 and D4 receptors in human neuroblastoma and astrocytoma cells.

2 Aug 2009 BACKGROUND: Dopaminergic pathways that influence mood and behaviour are severely affected in cerebral hypoxia. In contrast, hypoxia promotes the differentiation of dopaminergic neurons. In order to clarify the hypoxic sensitivity of key dopaminergic ... Read more...

Latest indexed articles for 'Receptors, Dopamine D4'

These are the very latest articles for this heading:

• Reward-seeking and discrimination deficits displayed by hypodopaminergic mice are prevented in mice lacking dopamine D4 receptors. 30 Oct 2009
• A balancing act: D4 receptor activation and the neurobiological basis of emotional learning. 31 Aug 2009
• Dopamine D2, D3, and D4 selective phenylpiperazines as molecular probes to explore the origins of subtype specific receptor binding. 11 Aug 2009
• Hypoxia-induced transcription of dopamine D3 and D4 receptors in human neuroblastoma and astrocytoma cells. 2 Aug 2009
• Genetic and environmental influence on attachment disorganization. 30 Jul 2009
• Interaction between serotonin transporter promoter and dopamine receptor D4 polymorphisms on decision making. 13 Jul 2009
• Minor genetic variants of the dopamine D4 receptor (DRD4) polymorphism are associated with novelty seeking in healthy Japanese subjects. 10 Jul 2009
• Penile erection and yawning induced by dopamine D2-like receptor agonists in rats: influence of strain and contribution of dopamine D2, but not D3 and D4 receptors. 29 Jun 2009
• [(3)H]-YM-09151-2 binding sites in human brain postmortem. 16 Jun 2009
• Candidate gene studies of ADHD: a meta-analytic review. 7 Jun 2009
• Prenatal smoking and attention-deficit/hyperactivity disorder: DRD4-7R as a plasticity gene. 3 Jun 2009
• [The role of genetic variants of the dopaminergic system in heroin dependence] 30 May 2009
• [Association between nicotine dependence and the -521 promoter polymorfism of the dopamine D4 receptor in patients with major depression] 30 May 2009
• Dopamine receptors in human peripheral blood lymphocytes: changes in mRNA expression in opioid addiction. 11 May 2009
• Design, synthesis and dopamine D4 receptor binding activities of new N-heteroaromatic 5/6-ring Mannich bases. 10 May 2009
• Dopamine D4 receptor gene exon III polymorphism associated with binge drinking attitudinal phenotype. 29 Apr 2009
• N-(4-(4-(2,3-dichloro- or 2-methoxyphenyl)piperazin-1-yl)butyl)heterobiarylcarboxamides with functionalized linking chains as high affinity and enantioselective D3 receptor antagonists. 21 Apr 2009
• Three amino acids in the D2 dopamine receptor regulate selective ligand function and affinity. 14 Apr 2009
• Dopamine D1 versus D4 receptors differentially modulate the encoding of salient versus nonsalient emotional information in the medial prefrontal cortex. 13 Apr 2009
• 5-HTT, DRD4, and COMT genes polymorphisms are not associated with fear during childbirth in Korea. 30 Mar 2009

See a longer list of these articles.

Technical information about 'Receptors, Dopamine D4'

Definition: A subtype of dopamine D2 receptors that has high affinity for the antipsychotic CLOZAPINE.

Registry Number: 137750-34-6

Descriptor UI: D050638

Alternative terms: Receptors, Dopamine D4; D4 Receptors, Dopamine; Dopamine D4 Receptors; Receptor, Dopamine D4; Dopamine D4 Receptor; D4 Receptor, Dopamine;

Allowable Qualifiers: deficiency; drug effects; genetics; history; immunology; isolation & purification; metabolism; physiology; radiation effects; therapeutic use; ultrastructure; chemistry; agonists; administration & dosage; analysis; antagonists & inhibitors; biosynthesis; blood; classification;

Tree Number: D12.776.543.750.070.300.400.500.500; D12.776.543.750.100.150.400.500.750; D12.776.543.750.720.300.300.400.500.500;

History Note: 2006(1991)

Technical Notes: see SCR for organism-specific terms