Receptors, GABA-A - Agonists
Research News and Information

Sunday, November 22, 2009

Differences in the activation of inhibitory motoneuron receptors in the frog Rana ridibunda by GABA and glycine and their interaction.

21 Sep 2009 Intracellular recording of potentials was used in isolated spinal cord segments from the frog Rana ridibunda to compare the inhibitory effects of GABA and glycine on the motoneuron membrane. At equal concentrations, the response (a change in ... Read more...

Synthesis, in vivo evaluation, and molecular modeling studies of new pyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide derivatives. Identification of a bifunctional hydrogen bond area related to the inverse agonism.

11 Aug 2009 A new series of pyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide 8-alkyloxy-/aryloxy-/arylalkyloxy and 8-aryl-/arylalkylderivatives variously substituted at the 3-position were synthesized and binding studies at the benzodiazepine site on GABA(A) ... Read more...

The rat prelimbic cortex mediates inhibitory response control but not the consolidation of instrumental learning.

30 Jul 2009 The potential role of the prelimbic cortex of the rat in the acquisition of instrumental responding is currently uncertain. In addition, modeling the acquisition of Pavlovian and spatial conditioning tasks has suggested that the process of ... Read more...

Latest indexed articles for 'Receptors, GABA-A - Agonists'

These are the very latest articles for this heading:

• Differences in the activation of inhibitory motoneuron receptors in the frog Rana ridibunda by GABA and glycine and their interaction. 21 Sep 2009
• Synthesis, in vivo evaluation, and molecular modeling studies of new pyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide derivatives. Identification of a bifunctional hydrogen bond area related to the inverse agonism. 11 Aug 2009
• The rat prelimbic cortex mediates inhibitory response control but not the consolidation of instrumental learning. 30 Jul 2009
• Behavioral characterization of amygdala involvement in mediating intra-accumbens opioid-driven feeding behavior. 30 Jul 2009
• Inhibitory actions of the gamma-aminobutyric acid in pediatric Sturge-Weber syndrome. 30 Jul 2009
• Triggers of apoptosis in the immature brain. 30 Jul 2009
• GABAergic analgesia: new insights from mutant mice and subtype-selective agonists. 14 Jul 2009
• Novel environment and GABA agonists alter event-related potentials in N-methyl-D-aspartate NR1 hypomorphic and wild-type mice. 12 Jul 2009
• Activation of GABA-A receptor ameliorates homocysteine-induced MMP-9 activation by ERK pathway. 29 Jun 2009
• Loss of GABAergic signaling by AgRP neurons to the parabrachial nucleus leads to starvation. 24 Jun 2009
• Identification of anxiolytic/nonsedative agents among indol-3-ylglyoxylamides acting as functionally selective agonists at the gamma-aminobutyric acid-A (GABAA) alpha2 benzodiazepine receptor. 23 Jun 2009
• Inverse effects on gating and modulation caused by a mutation in the M2-M3 Linker of the GABA(A) receptor gamma subunit. 22 Jun 2009
• Enhanced tonic GABA current in normotopic and hilar ectopic dentate granule cells after pilocarpine-induced status epilepticus. 25 May 2009
• Tone-specific and nonspecific plasticity of inferior colliculus elicited by pseudo-conditioning: role of acetylcholine and auditory and somatosensory cortices. 25 May 2009
• The shivering threshold in rabbits with JM-1232(-), a new benzodiazepine receptor agonist. 11 May 2009
• Brain regional distribution of GABA(A) receptors exhibiting atypical GABA agonism: roles of receptor subunits. 2 May 2009
• Comparison of five benzodiazepine-receptor agonists on buprenorphine-induced mu-opioid receptor regulation. 29 Apr 2009
• The effects of agonists of ionotropic GABA(A) and metabotropic GABA(B) receptors on learning. 29 Apr 2009
• Intrathecal injection of the neurosteroid, DHEAS, produces mechanical allodynia in mice: involvement of spinal sigma-1 and GABA receptors. 28 Apr 2009
• Different phases of afterdischarge during rapid kindling procedure in mice. 14 Apr 2009

See a longer list of these articles.

Technical information about 'Receptors, GABA-A'

Definition: Cell surface proteins which bind GAMMA-AMINOBUTYRIC ACID and control an integral membrane chloride channel. GABA-A receptors are the most prevalent inhibitory neurotransmitter receptors in the brain. Several isoforms have been cloned, and they belong to a superfamily which includes nicotinic receptors, glycine receptors, and 5HT-3 receptors. Most GABA-A receptors have separate modulatory sites sensitive to benzodiazepines and to barbiturates.

Registry Number: 0

Descriptor UI: D011963

Alternative terms: Receptors, GABA-A; Receptors, GABA A; GABA-A Receptor; GABA A Receptor; Receptor, GABA-A; GABA-A Receptors; GABA A Receptors; Muscimol Receptor; Receptor, Muscimol; Muscimol Receptors; Receptors, Benzodiazepine-GABA; Receptors, Benzodiazepine GABA; Benzodiazepine-GABA Receptor; Benzodiazepine GABA Receptor; Receptor, Benzodiazepine-GABA; GABA-Benzodiazepine Receptor; GABA Benzodiazepine Receptor; Receptor, GABA-Benzodiazepine; GABA-Benzodiazepine Receptors; GABA Benzodiazepine Receptors; Benzodiazepine-Gaba Receptors; Benzodiazepine Gaba Receptors; Receptors, GABA-Benzodiazepine; Receptors, GABA Benzodiazepine; GABA(A) Receptor; Receptors, Muscimol; Benzodiazepine Receptor; Receptor, Benzodiazepine; Receptors, Diazepam; Diazepam Receptor; Receptor, Diazepam; Diazepam Receptors; Benzodiazepine Receptors; Receptors, Benzodiazepine;

Allowable Qualifiers: administration & dosage; analysis; antagonists & inhibitors; biosynthesis; blood; classification; deficiency; drug effects; genetics; history; immunology; isolation & purification; metabolism; physiology; radiation effects; therapeutic use; ultrastructure; chemistry; agonists;

Tree Number: D12.776.543.750.720.200.300.300;

Online Note: use RECEPTORS, GABA-A to search RECEPTORS, GABA-BENZODIAZEPINE 1985-93

History Note: 94; was RECEPTORS, GABA-BENZODIAZEPINE 1985-93

Technical Notes: DF: RECEPT GABA A