Receptors, GABA-A - Drug effects
Research News and Information

Monday, November 23, 2009

Rapid use-dependent down-regulation of gamma-aminobutyric acid type A receptors in rat mesencephalic trigeminal neurons.

30 Oct 2009 Rundown is ubiquitously seen in response to repetitive activation of receptor or ion channels as a use-dependent down-regulation through various mechanisms. In contrast to AMPA receptors, gamma-aminobutyric acid type A receptor (GABA(A)R) are ... Read more...

Etomidate targets alpha5 gamma-aminobutyric acid subtype A receptors to regulate synaptic plasticity and memory blockade.

30 Oct 2009 BACKGROUND: The memory-blocking properties of general anesthetics have recently received considerable attention because of concerns related to intraoperative awareness and postoperative cognitive dysfunction. The goal of this study was to identify ... Read more...

Ubiquitin-dependent lysosomal targeting of GABA(A) receptors regulates neuronal inhibition.

4 Oct 2009 The strength of synaptic inhibition depends partly on the number of GABA(A) receptors (GABA(A)Rs) found at synaptic sites. The trafficking of GABA(A)Rs within the endocytic pathway is a key determinant of surface GABA(A)R number and is altered in ... Read more...

Latest indexed articles for 'Receptors, GABA-A - Drug effects'

These are the very latest articles for this heading:

• Rapid use-dependent down-regulation of gamma-aminobutyric acid type A receptors in rat mesencephalic trigeminal neurons. 30 Oct 2009
• Etomidate targets alpha5 gamma-aminobutyric acid subtype A receptors to regulate synaptic plasticity and memory blockade. 30 Oct 2009
• Ubiquitin-dependent lysosomal targeting of GABA(A) receptors regulates neuronal inhibition. 4 Oct 2009
• Angiotensin II enhances GABA(B) receptor-mediated responses and expression in nucleus tractus solitarii of rats. 9 Sep 2009
• Developing analgesics by enhancing spinal inhibition after injury: GABAA receptor subtypes as novel targets. 31 Aug 2009
• Differential effects of lorazepam on sleep and activity in C57BL/6J and BALB/cJ strain mice. 30 Aug 2009
• Hibernation induces pentobarbital insensitivity in medulla but not cortex. 10 Aug 2009
• The impact of diazepam's discovery on the treatment and understanding of status epilepticus. 6 Aug 2009
• Methoxycarbonyl-etomidate: a novel rapidly metabolized and ultra-short-acting etomidate analogue that does not produce prolonged adrenocortical suppression. 30 Jul 2009
• The complexity of the GABAA receptor shapes unique pharmacological profiles. 30 Jun 2009
• [Research progress on the mechanism of protection of neuroactive steroids against central lesions] 29 Jun 2009
• Potentiating effect of eszopiclone on GABA(A) receptor-mediated responses in pedunculopontine neurons. 29 Jun 2009
• Factual errors in Brooks and Peever's rebuttal to critiques. 29 Jun 2009
• Effects of sevoflurane on primary neuronal cultures of embryonic rats. 29 Jun 2009
• Presynaptic actions of propofol enhance inhibitory synaptic transmission in isolated solitary tract nucleus neurons. 23 Jun 2009
• The tuberal lateral hypothalamus is a major target for GABAA--but not GABAB-mediated control of food intake. 4 Jun 2009
• Interactions of Magnolia and Ziziphus extracts with selected central nervous system receptors. 4 Jun 2009
• In vitro effects of fipronil on neuronal excitability in mammalian and molluscan nervous systems. 30 May 2009
• Neonatal allopregnanolone increases novelty-directed locomotion and disrupts behavioural responses to GABA(A) receptor modulators in adulthood. 25 May 2009
• Benzodiazepine modulation of GABA(A) receptor opening frequency depends on activation context: a patch clamp and simulation study. 13 May 2009

See a longer list of these articles.

Technical information about 'Receptors, GABA-A'

Definition: Cell surface proteins which bind GAMMA-AMINOBUTYRIC ACID and control an integral membrane chloride channel. GABA-A receptors are the most prevalent inhibitory neurotransmitter receptors in the brain. Several isoforms have been cloned, and they belong to a superfamily which includes nicotinic receptors, glycine receptors, and 5HT-3 receptors. Most GABA-A receptors have separate modulatory sites sensitive to benzodiazepines and to barbiturates.

Registry Number: 0

Descriptor UI: D011963

Alternative terms: Receptors, GABA-A; Receptors, GABA A; GABA-A Receptor; GABA A Receptor; Receptor, GABA-A; GABA-A Receptors; GABA A Receptors; Muscimol Receptor; Receptor, Muscimol; Muscimol Receptors; Receptors, Benzodiazepine-GABA; Receptors, Benzodiazepine GABA; Benzodiazepine-GABA Receptor; Benzodiazepine GABA Receptor; Receptor, Benzodiazepine-GABA; GABA-Benzodiazepine Receptor; GABA Benzodiazepine Receptor; Receptor, GABA-Benzodiazepine; GABA-Benzodiazepine Receptors; GABA Benzodiazepine Receptors; Benzodiazepine-Gaba Receptors; Benzodiazepine Gaba Receptors; Receptors, GABA-Benzodiazepine; Receptors, GABA Benzodiazepine; GABA(A) Receptor; Receptors, Muscimol; Benzodiazepine Receptor; Receptor, Benzodiazepine; Receptors, Diazepam; Diazepam Receptor; Receptor, Diazepam; Diazepam Receptors; Benzodiazepine Receptors; Receptors, Benzodiazepine;

Allowable Qualifiers: administration & dosage; analysis; antagonists & inhibitors; biosynthesis; blood; classification; deficiency; drug effects; genetics; history; immunology; isolation & purification; metabolism; physiology; radiation effects; therapeutic use; ultrastructure; chemistry; agonists;

Tree Number: D12.776.543.750.720.200.300.300;

Online Note: use RECEPTORS, GABA-A to search RECEPTORS, GABA-BENZODIAZEPINE 1985-93

History Note: 94; was RECEPTORS, GABA-BENZODIAZEPINE 1985-93

Technical Notes: DF: RECEPT GABA A