Receptors, GABA-A
Research News and Information

Saturday, November 21, 2009

Rapid use-dependent down-regulation of gamma-aminobutyric acid type A receptors in rat mesencephalic trigeminal neurons.

30 Oct 2009 Rundown is ubiquitously seen in response to repetitive activation of receptor or ion channels as a use-dependent down-regulation through various mechanisms. In contrast to AMPA receptors, gamma-aminobutyric acid type A receptor (GABA(A)R) are ... Read more...

Etomidate targets alpha5 gamma-aminobutyric acid subtype A receptors to regulate synaptic plasticity and memory blockade.

30 Oct 2009 BACKGROUND: The memory-blocking properties of general anesthetics have recently received considerable attention because of concerns related to intraoperative awareness and postoperative cognitive dysfunction. The goal of this study was to identify ... Read more...

Extrasynaptic GABAA receptors: form, pharmacology, and function.

12 Oct 2009 GABA is the principal inhibitory neurotransmitter in the CNS and acts via GABA(A) and GABA(B) receptors. Recently, a novel form of GABA(A) receptor-mediated inhibition, termed "tonic" inhibition, has been described. Whereas synaptic GABA(A) ... Read more...

Latest indexed articles for 'Receptors, GABA-A'

These are the very latest articles for this heading:

• Rapid use-dependent down-regulation of gamma-aminobutyric acid type A receptors in rat mesencephalic trigeminal neurons. 30 Oct 2009
• Etomidate targets alpha5 gamma-aminobutyric acid subtype A receptors to regulate synaptic plasticity and memory blockade. 30 Oct 2009
• Extrasynaptic GABAA receptors: form, pharmacology, and function. 12 Oct 2009
• Cocaine exposure in utero alters synaptic plasticity in the medial prefrontal cortex of postnatal rats. 5 Oct 2009
• Ubiquitin-dependent lysosomal targeting of GABA(A) receptors regulates neuronal inhibition. 4 Oct 2009
• GABA uptake-dependent Ca(2+) signaling in developing olfactory bulb astrocytes. 28 Sep 2009
• Synthesis of fluorinated brassinosteroids based on alkene cross-metathesis and preliminary biological assessment. 22 Sep 2009
• Differences in the activation of inhibitory motoneuron receptors in the frog Rana ridibunda by GABA and glycine and their interaction. 21 Sep 2009
• Angiotensin II enhances GABA(B) receptor-mediated responses and expression in nucleus tractus solitarii of rats. 9 Sep 2009
• Differences in cortical versus subcortical GABAergic signaling: a candidate mechanism of electroclinical uncoupling of neonatal seizures. 8 Sep 2009
• Neuroligin 2 drives postsynaptic assembly at perisomatic inhibitory synapses through gephyrin and collybistin. 8 Sep 2009
• The ataxia (axJ) mutation causes abnormal GABAA receptor turnover in mice. 2 Sep 2009
• Inbred mouse strains differ in multiple hippocampal activity traits. 2 Sep 2009
• Developing analgesics by enhancing spinal inhibition after injury: GABAA receptor subtypes as novel targets. 31 Aug 2009
• GABAergic excitation of spider mechanoreceptors increases information capacity by increasing entropy rather than decreasing jitter. 31 Aug 2009
• Differential effects of lorazepam on sleep and activity in C57BL/6J and BALB/cJ strain mice. 30 Aug 2009
• Calcium control of gene regulation in rat hippocampal neuronal cultures. 30 Aug 2009
• Making sense of nonsense GABA(A) receptor mutations associated with genetic epilepsies. 29 Aug 2009
• Blockage of A2A and A3 adenosine receptors decreases the desensitization of human GABA(A) receptors microtransplanted to Xenopus oocytes. 29 Aug 2009
• Bidirectional control of spike timing by GABA(A) receptor-mediated inhibition during theta oscillation in CA1 pyramidal neurons. 24 Aug 2009

See a longer list of these articles.

Technical information about 'Receptors, GABA-A'

Definition: Cell surface proteins which bind GAMMA-AMINOBUTYRIC ACID and control an integral membrane chloride channel. GABA-A receptors are the most prevalent inhibitory neurotransmitter receptors in the brain. Several isoforms have been cloned, and they belong to a superfamily which includes nicotinic receptors, glycine receptors, and 5HT-3 receptors. Most GABA-A receptors have separate modulatory sites sensitive to benzodiazepines and to barbiturates.

Registry Number: 0

Descriptor UI: D011963

Alternative terms: Receptors, GABA-A; Receptors, GABA A; GABA-A Receptor; GABA A Receptor; Receptor, GABA-A; GABA-A Receptors; GABA A Receptors; Muscimol Receptor; Receptor, Muscimol; Muscimol Receptors; Receptors, Benzodiazepine-GABA; Receptors, Benzodiazepine GABA; Benzodiazepine-GABA Receptor; Benzodiazepine GABA Receptor; Receptor, Benzodiazepine-GABA; GABA-Benzodiazepine Receptor; GABA Benzodiazepine Receptor; Receptor, GABA-Benzodiazepine; GABA-Benzodiazepine Receptors; GABA Benzodiazepine Receptors; Benzodiazepine-Gaba Receptors; Benzodiazepine Gaba Receptors; Receptors, GABA-Benzodiazepine; Receptors, GABA Benzodiazepine; GABA(A) Receptor; Receptors, Muscimol; Benzodiazepine Receptor; Receptor, Benzodiazepine; Receptors, Diazepam; Diazepam Receptor; Receptor, Diazepam; Diazepam Receptors; Benzodiazepine Receptors; Receptors, Benzodiazepine;

Allowable Qualifiers: administration & dosage; analysis; antagonists & inhibitors; biosynthesis; blood; classification; deficiency; drug effects; genetics; history; immunology; isolation & purification; metabolism; physiology; radiation effects; therapeutic use; ultrastructure; chemistry; agonists;

Tree Number: D12.776.543.750.720.200.300.300;

Online Note: use RECEPTORS, GABA-A to search RECEPTORS, GABA-BENZODIAZEPINE 1985-93

History Note: 94; was RECEPTORS, GABA-BENZODIAZEPINE 1985-93

Technical Notes: DF: RECEPT GABA A