Receptors, GABA-B - Drug effects
Research News and Information

Tuesday, November 24, 2009

Angiotensin II enhances GABA(B) receptor-mediated responses and expression in nucleus tractus solitarii of rats.

9 Sep 2009 Angiotensin II (ANG II) increases GABA(B) receptor expression in neuronal cultures from the nucleus tractus solitarii (NTS). In the present study, the chronic effects of ANG II on GABA(B) receptor expression and activity were examined in the NTS of ... Read more...

GABA and cortical inhibition in motor and non-motor regions using combined TMS-EEG: a time analysis.

23 Jul 2009 OBJECTIVE: The induction of long interval cortical inhibition (LICI) in motor cortex with paired pulse transcranial magnetic stimulation (ppTMS) is an established paradigm for the assessment of cortical inhibition, proposed to be related to GABA(B) ... Read more...

The tuberal lateral hypothalamus is a major target for GABAA--but not GABAB-mediated control of food intake.

4 Jun 2009 The lateral hypothalamus (LH) is a site of integration for control mechanisms of feeding behavior as it has extensive reciprocal connections with multiple intrahypothalamic and extrahypothalamic brain areas. Evidence suggests that blockade of ... Read more...

Latest indexed articles for 'Receptors, GABA-B - Drug effects'

These are the very latest articles for this heading:

• Angiotensin II enhances GABA(B) receptor-mediated responses and expression in nucleus tractus solitarii of rats. 9 Sep 2009
• GABA and cortical inhibition in motor and non-motor regions using combined TMS-EEG: a time analysis. 23 Jul 2009
• The tuberal lateral hypothalamus is a major target for GABAA--but not GABAB-mediated control of food intake. 4 Jun 2009
• Infantile spasms and Down syndrome: a new animal model. 29 Apr 2009
• The effects of agonists of ionotropic GABA(A) and metabotropic GABA(B) receptors on learning. 29 Apr 2009
• CRF enhancement of GIRK channel-mediated transmission in dopamine neurons. 9 Mar 2009
• Differential NMDA-dependent activation of glial cells in mouse hippocampus. 13 Nov 2008
• Baclofen does not counteract the acute effects of ethanol on flash-evoked potentials in Long-Evans rats. 30 Oct 2008
• Epileptiform synchronization in the cingulate cortex. 28 Oct 2008
• Behavioral analyses of GHB: receptor mechanisms. 27 Oct 2008
• Neuroadaptive changes in the rat brain GABA(B) receptors after withdrawal from cocaine self-administration. 22 Sep 2008
• GABAB receptors within the ventral tegmental area are involved in the expression and acquisition of morphine-induced place preference in morphine-sensitized rats. 21 Aug 2008
• Receptor activation involving positive allosteric modulation, unlike full agonism, does not result in GABAB receptor desensitization. 13 Aug 2008
• Fentanyl treatment reduces GABAergic inhibition in the CA1 area of the hippocampus 24 h after acute exposure to the drug. 24 Jul 2008
• Specific reduction of alcohol's motivational properties by the positive allosteric modulator of the GABAB receptor, GS39783--comparison with the effect of the GABAB receptor direct agonist, baclofen. 7 Jul 2008
• GABA(B) receptor modulation of feedforward inhibition through hippocampal neurogliaform cells. 30 Jun 2008
• In vivo and in vitro ethanol exposure in prenatal rat brain: GABA(B) receptor modulation on dopamine D(1) receptor and protein kinase A. 29 Jun 2008
• Plasticity of pre- and postsynaptic GABAB receptor function in the paraventricular nucleus in spontaneously hypertensive rats. 18 Jun 2008
• Cataleptic effects of gamma-hydroxybutyrate (GHB) and baclofen in mice: mediation by GABA(B) receptors, but differential enhancement by N-methyl-d-aspartate (NMDA) receptor antagonists. 28 Apr 2008
• Characterization of (R,S)-5,7-di-tert-butyl-3-hydroxy-3-trifluoromethyl-3H-benzofuran-2-one as a positive allosteric modulator of GABAB receptors. 19 Apr 2008

See a longer list of these articles.

Technical information about 'Receptors, GABA-B'

Definition: Cell surface proteins which bind GAMMA-AMINOBUTYRIC ACID and influence cells via interactions with G-proteins. GABA-B receptors are pharmacologically characterized by their insensitivity to the blocker bicuculline and sensitivity to the agonist L-baclofen. They are found both presynaptically and postsynaptically, and act variously by inhibition of adenylate cyclase, activation of phospholipase A2, activation of potassium channels, and inactivation of voltage-activated calcium channels.

Registry Number: 0

Descriptor UI: D018080

Alternative terms: Receptors, GABA-B; Receptors, GABA B; GABA-B Receptor; GABA B Receptor; Receptor, GABA-B; Receptors, Baclofen; Baclofen Receptor; Receptor, Baclofen; Baclofen Receptors; GABA-B Receptors; GABA B Receptors;

Allowable Qualifiers: administration & dosage; analysis; antagonists & inhibitors; biosynthesis; blood; classification; deficiency; drug effects; genetics; history; immunology; isolation & purification; metabolism; physiology; radiation effects; therapeutic use; ultrastructure; chemistry; agonists;

Tree Number: D12.776.543.750.100.300; D12.776.543.750.720.200.300.320;

Online Note: use RECEPTORS, GABA-B (NM) to search BACLOFEN RECEPTORS 1985-93

History Note: 94; BACLOFEN RECEPTORS was BACLOFEN RECEPTOR (NM) 1985-93

Technical Notes: DF: RECEPT GABA B