Receptors, Glucocorticoid - Genetics
Research News and Information

Saturday, November 21, 2009

An epistatic ratchet constrains the direction of glucocorticoid receptor evolution.

22 Sep 2009 The extent to which evolution is reversible has long fascinated biologists. Most previous work on the reversibility of morphological and life-history evolution has been indecisive, because of uncertainty and bias in the methods used to infer ... Read more...

Corticosterone reduces dendritic complexity in developing hippocampal CA1 neurons.

30 Aug 2009 Although prolonged stress and corticosteroid exposure induce morphological changes in the hippocampal CA3 area, the adult CA1 area is quite resistant to such changes. Here we addressed the question whether elevated corticosteroid hormone levels ... Read more...

Vulnerability to depression: what is the role of stress genes in gene x environment interaction?

30 Aug 2009 Vulnerability to depression has been linked to the interaction of genetic predisposition with stressful life events. This review considers the associations between serotonergic and hypothalamic-pituitary-adrenal (HPA) systems. We follow the ... Read more...

Latest indexed articles for 'Receptors, Glucocorticoid - Genetics'

These are the very latest articles for this heading:

• An epistatic ratchet constrains the direction of glucocorticoid receptor evolution. 22 Sep 2009
• Corticosterone reduces dendritic complexity in developing hippocampal CA1 neurons. 30 Aug 2009
• Vulnerability to depression: what is the role of stress genes in gene x environment interaction? 30 Aug 2009
• Stable silencing of the glucocorticoid receptor in myelin-specific T effector cells by retroviral delivery of shRNA: insight into neuroinflammatory disease. 30 Aug 2009
• Interaction of mitochondrial thioredoxin with glucocorticoid receptor and NF-kappaB modulates glucocorticoid receptor and NF-kappaB signalling in HEK-293 cells. 25 Aug 2009
• Activity of the 5-HT1A receptor is involved in the alteration of glucocorticoid receptor in hippocampus and corticotropin-releasing factor in hypothalamus in SPS rats. 30 Jul 2009
• Novel human pathological mutations. Gene symbol: NR3C1. Disease: glucocorticoid receptor deficiency. 30 Jul 2009
• Identification of the functional domain of glucocorticoid receptor involved in RU486 antagonism. 23 Jul 2009
• Angiopoietin-like 4 (ANGPTL4, fasting-induced adipose factor) is a direct glucocorticoid receptor target and participates in glucocorticoid-regulated triglyceride metabolism. 21 Jul 2009
• Peony glycosides produce antidepressant-like action in mice exposed to chronic unpredictable mild stress: effects on hypothalamic-pituitary-adrenal function and brain-derived neurotrophic factor. 19 Jul 2009
• Bag-1M inhibits the transactivation of the glucocorticoid receptor via recruitment of corepressors. 13 Jul 2009
• Estrogen inhibits glucocorticoid action via protein phosphatase 5 (PP5)-mediated glucocorticoid receptor dephosphorylation. 6 Jul 2009
• Nuclear import of the glucocorticoid receptor-hsp90 complex through the nuclear pore complex is mediated by its interaction with Nup62 and importin beta. 4 Jul 2009
• Glucocorticoid receptor gene polymorphisms and childhood adversity are associated with depression: New evidence for a gene-environment interaction. 3 Jul 2009
• Glucocorticoid status affects antidepressant regulation of locus coeruleus tyrosine hydroxylase and dorsal raphé tryptophan hydroxylase gene expression. Jul 2009
• Glucocorticoid receptor in human respiratory epithelial cells. 27 Jun 2009
• Naturally occurring C-terminal splice variants of nuclear receptors. 17 Jun 2009
• Stress type dependence of expression and cytoplasmic-nuclear partitioning of glucocorticoid receptor, hsp90 and hsp70 in Wistar rat brain. 8 Jun 2009
• Characterization of a glucocorticoid receptor gene (GR, NR3C1) promoter polymorphism reveals functionality and extends a haplotype with putative clinical relevance. 3 Jun 2009
• Effect of glucocorticoid receptor gene polymorphisms in Guillain-Barré syndrome. 30 May 2009

See a longer list of these articles.

Technical information about 'Receptors, Glucocorticoid'

Definition: Cytoplasmic proteins that specifically bind glucocorticoids and mediate their cellular effects. The glucocorticoid receptor-glucocorticoid complex acts in the nucleus to induce transcription of DNA. Glucocorticoids were named for their actions on blood glucose concentration, but they have equally important effects on protein and fat metabolism. Cortisol is the most important example.

Registry Number: 0

Descriptor UI: D011965

Alternative terms: Receptors, Glucocorticoid; Glucocorticoid Receptors; Glucocorticoid Receptor; Receptor, Glucocorticoid; Receptors, Glucocorticoids; Glucocorticoids Receptors; Receptors, Corticoid Type II; Corticoid Type II Receptors; Corticoid II Receptor; Receptor, Corticoid II; Receptors, Corticoid II; Corticoid II Receptors;

Allowable Qualifiers: administration & dosage; analysis; antagonists & inhibitors; biosynthesis; blood; classification; deficiency; drug effects; genetics; history; immunology; isolation & purification; metabolism; physiology; radiation effects; therapeutic use; ultrastructure; chemistry; agonists;

Tree Number: D12.776.826.750.430; D12.776.930.682.430;

History Note: 86(77); was see under RECEPTORS, STEROID 1977-85

Technical Notes: coord IM with specific glucocorticoid (IM); DF: RECEPT GLUCOCORTICOID