Receptors, Histamine H1 - Genetics
Research News and Information

Monday, November 23, 2009

Suplatast tosilate inhibits histamine signaling by direct and indirect down-regulation of histamine H1 receptor gene expression through suppression of histidine decarboxylase and IL-4 gene transcriptions.

11 Jul 2009 Allergic rhinitis (AR) is an inflammatory disorder typified by symptoms such as sneezing, congestion, and rhinorrhea. Histamine plays important roles in eliciting AR symptoms. Up-regulation of the histamine H(1) receptor (H1R) and histidine ... Read more...

Differences in the expression of histamine-related genes and proteins in normal human adrenal cortex and adrenocortical tumors.

29 Jun 2009 Histamine is involved in the pathogenesis of several tumors; however, there are no data on its possible involvement in human adrenocortical tumorigenesis. The expression of genes and proteins involved in the biosynthesis (histidine decarboxylase, ... Read more...

Histamine H1 receptor knockout mice exhibit impaired spatial memory in the eight-arm radial maze.

29 Apr 2009 BACKGROUND AND PURPOSE: In the mammalian brain, histaminergic neurotransmission is mediated by the postsynaptic histamine H1 and H2 receptors and the presynaptic H3 autoreceptor, which also acts as a heteroreceptor. The H1 receptor has been ... Read more...

Latest indexed articles for 'Receptors, Histamine H1 - Genetics'

These are the very latest articles for this heading:

• Suplatast tosilate inhibits histamine signaling by direct and indirect down-regulation of histamine H1 receptor gene expression through suppression of histidine decarboxylase and IL-4 gene transcriptions. 11 Jul 2009
• Differences in the expression of histamine-related genes and proteins in normal human adrenal cortex and adrenocortical tumors. 29 Jun 2009
• Histamine H1 receptor knockout mice exhibit impaired spatial memory in the eight-arm radial maze. 29 Apr 2009
• Kujin suppresses histamine signaling at the transcriptional level in toluene 2,4-diisocyanate-sensitized rats. 5 Apr 2009
• Effects of hypergravity on histamine H1 receptor mRNA expression in hypothalamus and brainstem of rats: implications for development of motion sickness. 30 Dec 2008
• Repeated pre-treatment with antihistamines suppresses [corrected] transcriptional up-regulations of histamine H(1) receptor and interleukin-4 genes in toluene-2,4-diisocyanate-sensitized rats. 8 Dec 2008
• Histamine responses of large neostriatal interneurons in histamine H1 and H2 receptor knock-out mice. 4 Dec 2008
• Sho-seiryu-to suppresses histamine signaling at the transcriptional level in TDI-sensitized nasal allergy model rats. 29 Nov 2008
• Molecular basis for the selective interaction of synthetic agonists with the human histamine H1-receptor compared with the guinea pig H1-receptor. 29 Nov 2008
• New oral H1 antihistamines in children: facts and unmeet needs. 29 Sep 2008
• Suppression of histamine signaling by probiotic Lac-B: a possible mechanism of its anti-allergic effect. 3 Jun 2008
• Autoimmune disease-associated histamine receptor H1 alleles exhibit differential protein trafficking and cell surface expression. 30 May 2008
• Histamine H1-receptor antagonists inhibit nuclear factor-kappaB and activator protein-1 activities via H1-receptor-dependent and -independent mechanisms. 30 May 2008
• Time-dependent ventilatory response to poikilocapnic hypoxia during light and dark periods and the role of histamine H1 receptors in mice. 23 Mar 2008
• Short- and long-term effects of antipsychotic drug treatment on weight gain and H1 receptor expression. 18 Mar 2008
• Genetic variability of histamine receptors in patients with Parkinson's disease. 15 Mar 2008
• The histamine H1-receptor mediates the motivational effects of novelty. 5 Mar 2008
• Histamine H1 receptors are expressed in mouse and frog semicircular canal sensory epithelia. 3 Mar 2008
• Progress in allergy signal research on mast cells: up-regulation of histamine signal-related gene expression in allergy model rats. 28 Feb 2008
• GPCR proteomics: mass spectrometric and functional analysis of histamine H1 receptor after baculovirus-driven and in vitro cell free expression. 30 Jan 2008

See a longer list of these articles.

Technical information about 'Receptors, Histamine H1'

Definition: A class of histamine receptors discriminated by their pharmacology and mode of action. Most histamine H1 receptors operate through the inositol phosphate/diacylglycerol second messenger system. Among the many responses mediated by these receptors are smooth muscle contraction, increased vascular permeability, hormone release, and cerebral glyconeogenesis. (From Biochem Soc Trans 1992 Feb;20(1):122-5)

Registry Number: 0

Descriptor UI: D011969

Alternative terms: Receptors, Histamine H1; Histamine H1 Receptors; H1 Receptors, Histamine; Receptors, H1; H1 Receptors; Histamine H1 Receptor; H1 Receptor, Histamine; Receptor, Histamine H1;

Allowable Qualifiers: administration & dosage; analysis; biosynthesis; blood; classification; deficiency; drug effects; genetics; history; immunology; isolation & purification; metabolism; physiology; radiation effects; therapeutic use; ultrastructure; chemistry;

Tree Number: D12.776.543.750.070.450.100; D12.776.543.750.100.350; D12.776.543.750.720.300.450.300;

History Note: 89(77); was see under RECEPTORS, HISTAMINE 1977-88

Technical Notes: receptors for only the classical "antihistaminics"; DF: RECEPT H1