Receptors, Histamine H1
Research News and Information

Sunday, November 22, 2009

Mast cells down-regulate CD4+CD25+ T regulatory cell suppressor function via histamine H1 receptor interaction.

8 Aug 2009 Mast cells promote both innate and acquired immune responses, but little is known about the effect of mast cells on T regulatory (T(reg)) cell function. In this study, we show for the first time that the capacity of murine CD4(+)CD25(+) T(reg) cells ... Read more...

Suplatast tosilate inhibits histamine signaling by direct and indirect down-regulation of histamine H1 receptor gene expression through suppression of histidine decarboxylase and IL-4 gene transcriptions.

11 Jul 2009 Allergic rhinitis (AR) is an inflammatory disorder typified by symptoms such as sneezing, congestion, and rhinorrhea. Histamine plays important roles in eliciting AR symptoms. Up-regulation of the histamine H(1) receptor (H1R) and histidine ... Read more...

Hypothalamic neuronal histamine signaling in the estrogen deficiency-induced obesity.

6 Jul 2009 Menopause is one of the triggers that induce obesity. Estradiol (E2), corticotropin-releasing hormone (CRH), and hypothalamic neuronal histamine are anorexigenic substances within the hypothalamus. This study examined the interactions among E2, CRH, ... Read more...

Latest indexed articles for 'Receptors, Histamine H1'

These are the very latest articles for this heading:

• Mast cells down-regulate CD4+CD25+ T regulatory cell suppressor function via histamine H1 receptor interaction. 8 Aug 2009
• Suplatast tosilate inhibits histamine signaling by direct and indirect down-regulation of histamine H1 receptor gene expression through suppression of histidine decarboxylase and IL-4 gene transcriptions. 11 Jul 2009
• Hypothalamic neuronal histamine signaling in the estrogen deficiency-induced obesity. 6 Jul 2009
• Differences in the expression of histamine-related genes and proteins in normal human adrenal cortex and adrenocortical tumors. 29 Jun 2009
• Histamine H1 receptor induces cytosolic calcium increase and aquaporin translocation in human salivary gland cells. 12 May 2009
• Cerebral histamine H1 receptor binding potential measured with PET under a test dose of olopatadine, an antihistamine, is reduced after repeated administration of olopatadine. 12 May 2009
• Histamine hyperpolarizes human glioblastoma cells by activating the intermediate-conductance Ca2+-activated K+ channel. 4 May 2009
• Efficacy and safety of bilastine 20 mg compared with cetirizine 10 mg and placebo for the symptomatic treatment of seasonal allergic rhinitis: a randomized, double-blind, parallel-group study. 2 May 2009
• Synthesis and biological evaluation of novel gamma-carboline analogues of Dimebon as potent 5-HT6 receptor antagonists. May 2009
• Histamine H1 receptor knockout mice exhibit impaired spatial memory in the eight-arm radial maze. 29 Apr 2009
• Kujin suppresses histamine signaling at the transcriptional level in toluene 2,4-diisocyanate-sensitized rats. 5 Apr 2009
• Contribution of binding enthalpy and entropy to affinity of antagonist and agonist binding at human and guinea pig histamine H(1)-receptor. Apr 2009
• G-protein coupled receptor array technologies: site directed immobilisation of liposomes containing the H1-histamine or M2-muscarinic receptors. 30 Mar 2009
• Synthesis and structure-activity relationships of phenothiazine carboxylic acids having pyrimidine-dione as novel histamine H(1) antagonists. 26 Mar 2009
• Extraction of membrane cholesterol disrupts caveolae and impairs serotonergic (5-HT2A) and histaminergic (H1) responses in bovine airway smooth muscle: role of Rho-kinase. 27 Feb 2009
• Update on prescription and over-the-counter histamine inverse agonists in rhinitis therapy. 27 Feb 2009
• The lignan eudesmin extracted from Piper truncatum induced vascular relaxation via activation of endothelial histamine H1 receptors. 3 Feb 2009
• Analytical method for simultaneously measuring ex vivo drug receptor occupancy and dissociation rate: application to (R)-dimethindene occupancy of central histamine H1 receptors. 30 Dec 2008
• Effects of hypergravity on histamine H1 receptor mRNA expression in hypothalamus and brainstem of rats: implications for development of motion sickness. 30 Dec 2008
• Histamine induces postprandial tachycardia through a direct effect on cardiac H2-receptors in pythons. 15 Dec 2008

See a longer list of these articles.

Technical information about 'Receptors, Histamine H1'

Definition: A class of histamine receptors discriminated by their pharmacology and mode of action. Most histamine H1 receptors operate through the inositol phosphate/diacylglycerol second messenger system. Among the many responses mediated by these receptors are smooth muscle contraction, increased vascular permeability, hormone release, and cerebral glyconeogenesis. (From Biochem Soc Trans 1992 Feb;20(1):122-5)

Registry Number: 0

Descriptor UI: D011969

Alternative terms: Receptors, Histamine H1; Histamine H1 Receptors; H1 Receptors, Histamine; Receptors, H1; H1 Receptors; Histamine H1 Receptor; H1 Receptor, Histamine; Receptor, Histamine H1;

Allowable Qualifiers: administration & dosage; analysis; biosynthesis; blood; classification; deficiency; drug effects; genetics; history; immunology; isolation & purification; metabolism; physiology; radiation effects; therapeutic use; ultrastructure; chemistry;

Tree Number: D12.776.543.750.070.450.100; D12.776.543.750.100.350; D12.776.543.750.720.300.450.300;

History Note: 89(77); was see under RECEPTORS, HISTAMINE 1977-88

Technical Notes: receptors for only the classical "antihistaminics"; DF: RECEPT H1