Receptors, Metabotropic Glutamate
Research News and Information

Sunday, November 22, 2009

Prostaglandin E2-induced masculinization of brain and behavior requires protein kinase A, AMPA/kainate, and metabotropic glutamate receptor signaling.

19 Oct 2009 Prostaglandin E(2) (PGE(2)) mediates the masculinization of adult sex behavior in rats in response to the surge in serum testosterone at approximately birth. Measures of behavioral masculinization correlate with a twofold increase in spinophilin ... Read more...

Group I mGluR activation enhances Ca(2+)-dependent nonselective cation currents and rhythmic bursting in main olfactory bulb external tufted cells.

21 Sep 2009 In the main olfactory bulb, activation of group I metabotropic glutamate receptors (mGluRs) by olfactory nerve stimulation generates slow (2 Hz) oscillations near the basal respiratory frequency. These oscillations arise in the glomerular layer and ... Read more...

A novel postsynaptic group II metabotropic glutamate receptor role in modulating baroreceptor signal transmission.

21 Sep 2009 The nucleus tractus solitarius (NTS) is essential for orchestrating baroreflex control of blood pressure. When a change in blood pressure occurs, the information is transmitted by baroreceptor afferent fibers to the central network by glutamate ... Read more...

Latest indexed articles for 'Receptors, Metabotropic Glutamate'

These are the very latest articles for this heading:

• Prostaglandin E2-induced masculinization of brain and behavior requires protein kinase A, AMPA/kainate, and metabotropic glutamate receptor signaling. 19 Oct 2009
• Group I mGluR activation enhances Ca(2+)-dependent nonselective cation currents and rhythmic bursting in main olfactory bulb external tufted cells. 21 Sep 2009
• A novel postsynaptic group II metabotropic glutamate receptor role in modulating baroreceptor signal transmission. 21 Sep 2009
• Signal transduction mechanisms underlying group I mGluR-mediated increase in frequency and amplitude of spontaneous EPSCs in the spinal trigeminal subnucleus oralis of the rat. 31 Aug 2009
• Phospholipase Cbeta4 expression identifies a novel subset of unipolar brush cells in the adult mouse cerebellum. 30 Aug 2009
• Positive allosteric modulators of the metabotropic glutamate receptor 2 for the treatment of schizophrenia. 30 Aug 2009
• Differential distribution of endoplasmic reticulum controls metabotropic signaling and plasticity at hippocampal synapses. 16 Aug 2009
• The association of metabotropic glutamate receptor type 5 with the neuronal Ca2+-binding protein 2 modulates receptor function. 16 Aug 2009
• Membrane-delimited coupling of TRPV1 and mGluR5 on presynaptic terminals of nociceptive neurons. 10 Aug 2009
• BC1 regulation of metabotropic glutamate receptor-mediated neuronal excitability. 10 Aug 2009
• Functional coupling between mGluR1 and Cav3.1 T-type calcium channels contributes to parallel fiber-induced fast calcium signaling within Purkinje cell dendritic spines. 3 Aug 2009
• Against addiction: light at the end of the tunnel? 30 Jul 2009
• Behavioural profile of selective ligands for mGlu7 and mGlu8 glutamate receptors in agonistic encounters between mice. 30 Jul 2009
• A new kind of drug target. 30 Jul 2009
• Phenotypic characterization of mice heterozygous for a null mutation of glutamate carboxypeptidase II. 30 Jul 2009
• Interoceptive effects of alcohol require mGlu5 receptor activity in the nucleus accumbens. 27 Jul 2009
• Activation of metabotropic glutamate receptor type 2/3 supports the involvement of the hippocampal mossy fiber pathway on contextual fear memory consolidation. 26 Jul 2009
• Disruption of glutamate receptors at Shank-postsynaptic platform in Alzheimer's disease. 23 Jul 2009
• Discovery of molecular switches that modulate modes of metabotropic glutamate receptor subtype 5 (mGlu5) pharmacology in vitro and in vivo within a series of functionalized, regioisomeric 2- and 5-(phenylethynyl)pyrimidines. 21 Jul 2009
• Synthesis and evaluation of a series of heterobiarylamides that are centrally penetrant metabotropic glutamate receptor 4 (mGluR4) positive allosteric modulators (PAMs). 21 Jul 2009

See a longer list of these articles.

Technical information about 'Receptors, Metabotropic Glutamate'

Definition: Cell surface proteins that bind glutamate and act through G-proteins to influence second messenger systems. Several types of metabotropic glutamate receptors have been cloned. They differ in pharmacology, distribution, and mechanisms of action.

Registry Number: 0

Descriptor UI: D018094

Alternative terms: Receptors, Metabotropic Glutamate; Glutamate Receptors, Metabotropic; Receptors, Glutamate, Metabotropic; Metabotropic Glutamate Receptor; Glutamate Receptor, Metabotropic; Receptor, Metabotropic Glutamate; Metabotropic Glutamate Receptors;

Allowable Qualifiers: administration & dosage; analysis; antagonists & inhibitors; biosynthesis; blood; classification; deficiency; drug effects; genetics; history; immunology; isolation & purification; metabolism; physiology; radiation effects; therapeutic use; ultrastructure; chemistry; agonists;

Tree Number: D12.776.543.750.100.450; D12.776.543.750.720.200.450.500;

History Note: 94

Technical Notes: metabotropic refers to action via the second messenger system; DF: RECEPT METAB GLUTAMATE