Receptors, N-Methyl-D-Aspartate - Antagonists & inhibitors
Research News and Information

Saturday, November 21, 2009

The peripheral antinociceptive effects of endomorphin-1 and kynurenic acid in the rat inflamed joint model.

29 Sep 2009 BACKGROUND: Several data suggest that both opioid and N-methyl-d-aspartate (NMDA) receptors are localized at the peripheral level, and drugs acting on these receptors may produce antinociception after topical administration; however, the ... Read more...

Interference with cellular differentiation by D-serine through antagonism at N-methyl-D-aspartate receptors composed of NR1 and NR3A subunits in chondrocytes.

30 Aug 2009 Serine racemase (SR) is responsible for the biosynthesis of D-serine (D-Ser), an endogenous co-agonist for the glycine (Gly)-binding site on N-methyl-D-aspartate (NMDA) receptors, from L-Ser in the brain. We have previously demonstrated high ... Read more...

Calcium control of gene regulation in rat hippocampal neuronal cultures.

30 Aug 2009 Blockage of GABA-A receptors in hippocampal neuronal cultures triggers synchronous bursts of spikes initiating neuronal plasticity, partly mediated by changes of gene expression. By using specific pharmacological blockers, we have investigated which ... Read more...

Latest indexed articles for 'Receptors, N-Methyl-D-Aspartate - Antagonists & inhibitors'

These are the very latest articles for this heading:

• The peripheral antinociceptive effects of endomorphin-1 and kynurenic acid in the rat inflamed joint model. 29 Sep 2009
• Anti-NMDA receptor antibodies encephalitis. 30 Aug 2009
• Interference with cellular differentiation by D-serine through antagonism at N-methyl-D-aspartate receptors composed of NR1 and NR3A subunits in chondrocytes. 30 Aug 2009
• Calcium control of gene regulation in rat hippocampal neuronal cultures. 30 Aug 2009
• Intradermal administration of magnesium sulphate and magnesium chloride produces hypesthesia to mechanical but hyperalgesia to heat stimuli in humans. 26 Aug 2009
• Spatial discrimination reversal learning in weanling rats is impaired by striatal administration of an NMDA-receptor antagonist. 25 Aug 2009
• 4'-Demethylnobiletin, a bioactive metabolite of nobiletin enhancing PKA/ERK/CREB signaling, rescues learning impairment associated with NMDA receptor antagonism via stimulation of the ERK cascade. 16 Aug 2009
• Blockade of NMDA receptors and nitric oxide synthesis in the dorsolateral periaqueductal gray attenuates behavioral and cellular responses of rats exposed to a live predator. 13 Aug 2009
• Two forms of long-term depression in a polysynaptic pathway in the leech CNS: one NMDA receptor-dependent and the other cannabinoid-dependent. 4 Aug 2009
• Kinetic basis of partial agonism at NMDA receptors. 31 Jul 2009
• Cannabinoid modulation of hippocampal long-term memory is mediated by mTOR signaling. 31 Jul 2009
• Development of a behavior model of pain induced by experimental tooth movement in rats. 30 Jul 2009
• Synaptic potentiation induces increased glial coverage of excitatory synapses in CA1 hippocampus. 30 Jul 2009
• Triggers of apoptosis in the immature brain. 30 Jul 2009
• Comments on "An innovative design to establish proof of concept of the antidepressant effects of the NR2B subunit selective N-methyl-D-aspartate antagonist, CP-101,606 in patients with treatment-refractory major depressive disorder". 30 Jul 2009
• Synthesis and biological evaluation of a new set of pyrazolo[1,5-c]quinazolines as glycine/N-methyl-D-aspartic acid receptor antagonists. 30 Jul 2009
• Genomic analysis of ischemic preconditioning in adult rat hippocampal slice cultures. 20 Jul 2009
• Effects of glutamate and alpha2-noradrenergic receptor antagonists on the development of neurotoxicity produced by chronic rotenone in rats. 15 Jul 2009
• Postsynaptic mechanisms govern the differential excitation of cortical neurons by thalamic inputs. 13 Jul 2009
• NR2A at CA1 synapses is obligatory for the susceptibility of hippocampal plasticity to sleep loss. 13 Jul 2009

See a longer list of these articles.

Technical information about 'Receptors, N-Methyl-D-Aspartate'

Definition: A class of ionotropic glutamate receptors characterized by affinity for N-methyl-D-aspartate. NMDA receptors have an allosteric binding site for glycine which must be occupied for the channel to open efficiently and a site within the channel itself to which magnesium ions bind in a voltage-dependent manner. The positive voltage dependence of channel conductance and the high permeability of the conducting channel to calcium ions (as well as to monovalent cations) are important in excitotoxicity and neuronal plasticity.

Registry Number: 0

Descriptor UI: D016194

Alternative terms: Receptors, N-Methyl-D-Aspartate; Receptors, N Methyl D Aspartate; N-Methyl-D-Aspartate Receptors; N Methyl D Aspartate Receptors; NMDA Receptors; Receptors, N-Methylaspartate; Receptors, N Methylaspartate; Receptors, NMDA; NMDA Receptor-Ionophore Complex; NMDA Receptor Ionophore Complex; N-Methylaspartate Receptors; N Methylaspartate Receptors;

Allowable Qualifiers: administration & dosage; analysis; antagonists & inhibitors; biosynthesis; blood; classification; deficiency; drug effects; genetics; history; immunology; isolation & purification; metabolism; physiology; radiation effects; therapeutic use; ultrastructure; chemistry; agonists;

Tree Number: D12.776.543.750.720.200.450.580;

Online Note: use RECEPTORS, N-METHYL-D-ASPARTATE to search RECEPTOR, N-METHYL-D-ASPARTATE & N-METHYL-D-ASPARTATE RECEPTOR 1991-92

History Note: 93; was RECEPTOR, N-METHYL-D-ASPARTATE 1991-92; N-METHYL-D-ASPARTATE RECEPTORS was N-METHYL-D-ASPARTATE RECEPTOR see RECEPTOR, N-METHYL-D-ASPARTATE 1991-92

Technical Notes: DF: RECEPT NMDA