Receptors, N-Methyl-D-Aspartate - Classification
Research News and Information

Sunday, November 22, 2009

Input-specific intrasynaptic arrangements of ionotropic glutamate receptors and their impact on postsynaptic responses.

12 Oct 2009 To examine the intrasynaptic arrangement of postsynaptic receptors in relation to the functional role of the synapse, we quantitatively analyzed the two-dimensional distribution of AMPA and NMDA receptors (AMPARs and NMDARs, respectively) using ... Read more...

Prolonged withdrawal from repeated noncontingent cocaine exposure increases NMDA receptor expression and ERK activity in the nucleus accumbens.

25 May 2009 Cocaine-induced changes in glutamatergic synaptic transmission in the ventral tegmental area (VTA) and the nucleus accumbens (NAc) play a key role in cocaine behavioral effects. Activation of ionotropic glutamate receptor NMDA receptor (NMDAR) in ... Read more...

Neuroligin1: a cell adhesion molecule that recruits PSD-95 and NMDA receptors by distinct mechanisms during synaptogenesis.

16 May 2009 BACKGROUND: The cell adhesion molecule pair neuroligin1 (Nlg1) and beta-neurexin (beta-NRX) is a powerful inducer of postsynaptic differentiation of glutamatergic synapses in vitro. Because Nlg1 induces accumulation of two essential components of ... Read more...

Latest indexed articles for 'Receptors, N-Methyl-D-Aspartate - Classification'

These are the very latest articles for this heading:

• Input-specific intrasynaptic arrangements of ionotropic glutamate receptors and their impact on postsynaptic responses. 12 Oct 2009
• Prolonged withdrawal from repeated noncontingent cocaine exposure increases NMDA receptor expression and ERK activity in the nucleus accumbens. 25 May 2009
• Neuroligin1: a cell adhesion molecule that recruits PSD-95 and NMDA receptors by distinct mechanisms during synaptogenesis. 16 May 2009
• Different structural requirements for functional ion pore transplantation suggest different gating mechanisms of NMDA and kainate receptors. 12 Aug 2008
• Assembly and forward trafficking of NMDA receptors (Review). 29 Apr 2008
• Role of NMDA receptor subtypes in different forms of NMDA-dependent synaptic plasticity. 24 Jul 2007
• What are the mechanisms underlying the involvement of different subtypes of NMDA receptors in inducing long-term potentiation and depression in the hippocampus? 30 May 2007
• Effects of pan- and subtype-selective N-methyl-D-aspartate receptor antagonists on cortical spreading depression in the rat: therapeutic potential for migraine. 29 Jan 2007
• Learning in the absence of experience-dependent regulation of NMDAR composition. 13 Sep 2006
• N-methyl-D-aspartate receptor subunit phenotypes of vagal afferent neurons in nodose ganglia of the rat. 18 Jun 2006
• Increase in tyrosine phosphorylation of the NMDA receptor following the induction of status epilepticus. 2 Apr 2006
• NMDA-receptor proteins are upregulated in the hippocampus of postnatal heterozygous reeler mice. 22 Jan 2006
• Cultivated keratinocytes express N-methyl-D-aspartate receptors of the NMDAR2D type. 15 Nov 2005
• Ontogeny of AMPA and NMDA receptor gene expression in the developing sheep white matter and cerebral cortex. Oct 2005
• Functional NR2B- and NR2D-containing NMDA receptor channels in rat substantia nigra dopaminergic neurones. 30 Aug 2005
• Memantine inhibits ethanol-induced NMDA receptor up-regulation in rat hippocampal neurons. 7 Aug 2005
• Dietary n-3 polyunsaturated fatty acid depletion activates caspases and decreases NMDA receptors in the brain of a transgenic mouse model of Alzheimer's disease. 30 Jul 2005
• Chronic intermittent ethanol exposure enhances NMDA-receptor-mediated synaptic responses and NMDA receptor expression in hippocampal CA1 region. 26 Jun 2005
• Upregulation of mRNAs coding for AMPA and NMDA receptor subunits and metabotropic glutamate receptors in the dorsal horn of the spinal cord in a rat model of diabetes mellitus. 18 May 2005
• Kinetics and subunit composition of NMDA receptors in respiratory-related neurons. 29 Apr 2005

See a longer list of these articles.

Technical information about 'Receptors, N-Methyl-D-Aspartate'

Definition: A class of ionotropic glutamate receptors characterized by affinity for N-methyl-D-aspartate. NMDA receptors have an allosteric binding site for glycine which must be occupied for the channel to open efficiently and a site within the channel itself to which magnesium ions bind in a voltage-dependent manner. The positive voltage dependence of channel conductance and the high permeability of the conducting channel to calcium ions (as well as to monovalent cations) are important in excitotoxicity and neuronal plasticity.

Registry Number: 0

Descriptor UI: D016194

Alternative terms: Receptors, N-Methyl-D-Aspartate; Receptors, N Methyl D Aspartate; N-Methyl-D-Aspartate Receptors; N Methyl D Aspartate Receptors; NMDA Receptors; Receptors, N-Methylaspartate; Receptors, N Methylaspartate; Receptors, NMDA; NMDA Receptor-Ionophore Complex; NMDA Receptor Ionophore Complex; N-Methylaspartate Receptors; N Methylaspartate Receptors;

Allowable Qualifiers: administration & dosage; analysis; antagonists & inhibitors; biosynthesis; blood; classification; deficiency; drug effects; genetics; history; immunology; isolation & purification; metabolism; physiology; radiation effects; therapeutic use; ultrastructure; chemistry; agonists;

Tree Number: D12.776.543.750.720.200.450.580;

Online Note: use RECEPTORS, N-METHYL-D-ASPARTATE to search RECEPTOR, N-METHYL-D-ASPARTATE & N-METHYL-D-ASPARTATE RECEPTOR 1991-92

History Note: 93; was RECEPTOR, N-METHYL-D-ASPARTATE 1991-92; N-METHYL-D-ASPARTATE RECEPTORS was N-METHYL-D-ASPARTATE RECEPTOR see RECEPTOR, N-METHYL-D-ASPARTATE 1991-92

Technical Notes: DF: RECEPT NMDA