Receptors, N-Methyl-D-Aspartate - Drug effects
Research News and Information

Sunday, November 22, 2009

Acute neurobehavioral effects of toluene: involvement of dopamine and NMDA receptors.

14 Sep 2009 Toluene, a widely used and commonly abused organic solvent, causes a variety of behavioral disturbances in both humans and animals. In this study, the effects of toluene on locomotor activity, motor coordination, and passive avoidance learning, ... Read more...

The vasodilatory effect of ketamine is independent of the N-methyl-D-aspartate receptor: lack of functional N-methyl-D-aspartate receptors in rat mesenteric artery smooth muscle.

30 Jul 2009 BACKGROUND AND OBJECTIVE: Ketamine, which is a general anaesthetic that induces a dissociative anaesthesia, acts by blocking the N-methyl-D-aspartate receptor (NMDAr) in the brain. Although ketamine elevates blood pressure under the clinical ... Read more...

The Alzheimer's disease drug memantine increases the number of radial glia-like progenitor cells in adult hippocampus.

30 Jul 2009 New neurons are continuously generated in the hippocampus of the adult mammalian brain, and N-methyl-D-aspartate receptor (NMDA-R) antagonists have been found to increase the number of newly generated neurons in the dentate gyrus (DG) of the adult ... Read more...

Latest indexed articles for 'Receptors, N-Methyl-D-Aspartate - Drug effects'

These are the very latest articles for this heading:

• Acute neurobehavioral effects of toluene: involvement of dopamine and NMDA receptors. 14 Sep 2009
• The vasodilatory effect of ketamine is independent of the N-methyl-D-aspartate receptor: lack of functional N-methyl-D-aspartate receptors in rat mesenteric artery smooth muscle. 30 Jul 2009
• The Alzheimer's disease drug memantine increases the number of radial glia-like progenitor cells in adult hippocampus. 30 Jul 2009
• Effect of caffeic acid and rofecoxib and their combination against intrastriatal quinolinic acid induced oxidative damage, mitochondrial and histological alterations in rats. 24 Jul 2009
• The excitotoxin quinolinic acid induces tau phosphorylation in human neurons. 20 Jul 2009
• Prolonged exposure to ammonia increases extracellular glutamate in cultured rat astrocytes. 30 Jun 2009
• [Research progress on the mechanism of protection of neuroactive steroids against central lesions] 29 Jun 2009
• Validating novel targets for pharmacological interventions in schizophrenia. 29 Jun 2009
• Role of N-methyl-D-aspartate and non-N-methyl-D-aspartate receptors in the cardiovascular effects of L-glutamate microinjection into the hypothalamic paraventricular nucleus of unanesthetized rats. 29 Jun 2009
• Possible protection by notoginsenoside R1 against glutamate neurotoxicity mediated by N-methyl-D-aspartate receptors composed of an NR1/NR2B subunit assembly. 29 Jun 2009
• Neonatal exposure to MK801 promotes prepulse-induced delay in startle response time in adult rats. 28 Jun 2009
• GABA action in immature neocortical neurons directly depends on the availability of ketone bodies. 20 Jun 2009
• Decline of long-term potentiation (LTP) in the rat auditory cortex in vivo during postnatal life: involvement of NR2B subunits. 7 Jun 2009
• Neuroprotective effect of memantine combined with topiramate in hypoxic-ischemic brain injury. 4 Jun 2009
• In vivo measurement of protein functional changes. 3 Jun 2009
• Mechanisms underlying morphine analgesic tolerance and dependence. 30 May 2009
• Metabotropic glutamate receptor 1 activity generates persistent, N-methyl-D-aspartate receptor-dependent depression of hippocampal pyramidal cell excitability. 27 May 2009
• Experimental occlusal interference induces long-term masticatory muscle hyperalgesia in rats. 24 May 2009
• Repeated 4-aminopyridine induced seizures diminish the efficacy of glutamatergic transmission in the neocortex. 11 May 2009
• Neuroprotective effect of ouabain and Bcl-2 peptide expression during hyperactivation of NMDA receptors in rat brain cortical neurons in vitro. 29 Apr 2009

See a longer list of these articles.

Technical information about 'Receptors, N-Methyl-D-Aspartate'

Definition: A class of ionotropic glutamate receptors characterized by affinity for N-methyl-D-aspartate. NMDA receptors have an allosteric binding site for glycine which must be occupied for the channel to open efficiently and a site within the channel itself to which magnesium ions bind in a voltage-dependent manner. The positive voltage dependence of channel conductance and the high permeability of the conducting channel to calcium ions (as well as to monovalent cations) are important in excitotoxicity and neuronal plasticity.

Registry Number: 0

Descriptor UI: D016194

Alternative terms: Receptors, N-Methyl-D-Aspartate; Receptors, N Methyl D Aspartate; N-Methyl-D-Aspartate Receptors; N Methyl D Aspartate Receptors; NMDA Receptors; Receptors, N-Methylaspartate; Receptors, N Methylaspartate; Receptors, NMDA; NMDA Receptor-Ionophore Complex; NMDA Receptor Ionophore Complex; N-Methylaspartate Receptors; N Methylaspartate Receptors;

Allowable Qualifiers: administration & dosage; analysis; antagonists & inhibitors; biosynthesis; blood; classification; deficiency; drug effects; genetics; history; immunology; isolation & purification; metabolism; physiology; radiation effects; therapeutic use; ultrastructure; chemistry; agonists;

Tree Number: D12.776.543.750.720.200.450.580;

Online Note: use RECEPTORS, N-METHYL-D-ASPARTATE to search RECEPTOR, N-METHYL-D-ASPARTATE & N-METHYL-D-ASPARTATE RECEPTOR 1991-92

History Note: 93; was RECEPTOR, N-METHYL-D-ASPARTATE 1991-92; N-METHYL-D-ASPARTATE RECEPTORS was N-METHYL-D-ASPARTATE RECEPTOR see RECEPTOR, N-METHYL-D-ASPARTATE 1991-92

Technical Notes: DF: RECEPT NMDA