Receptors, N-Methyl-D-Aspartate - Metabolism
Research News and Information

Saturday, November 21, 2009

Dual palmitoylation of NR2 subunits regulates NMDA receptor trafficking.

27 Oct 2009 Modification of NMDA receptor function and trafficking contributes to the regulation of synaptic transmission and is important for several forms of synaptic plasticity. Here, we report that NMDA receptor subunits NR2A and NR2B have two distinct ... Read more...

PIKfyve regulates CaV1.2 degradation and prevents excitotoxic cell death.

17 Oct 2009 Voltage-gated Ca(2+) channels (VGCCs) play a key role in neuronal signaling but can also contribute to cellular dysfunction and death under pathological conditions such as stroke and neurodegenerative diseases. We report that activation of ... Read more...

Input-specific intrasynaptic arrangements of ionotropic glutamate receptors and their impact on postsynaptic responses.

12 Oct 2009 To examine the intrasynaptic arrangement of postsynaptic receptors in relation to the functional role of the synapse, we quantitatively analyzed the two-dimensional distribution of AMPA and NMDA receptors (AMPARs and NMDARs, respectively) using ... Read more...

Latest indexed articles for 'Receptors, N-Methyl-D-Aspartate - Metabolism'

These are the very latest articles for this heading:

• Dual palmitoylation of NR2 subunits regulates NMDA receptor trafficking. 27 Oct 2009
• PIKfyve regulates CaV1.2 degradation and prevents excitotoxic cell death. 17 Oct 2009
• Input-specific intrasynaptic arrangements of ionotropic glutamate receptors and their impact on postsynaptic responses. 12 Oct 2009
• Autocrine activation of neuronal NMDA receptors by aspartate mediates dopamine- and cAMP-induced CREB-dependent gene transcription. 5 Oct 2009
• Increased expression of the NR2A NMDA receptor subunit in the prefrontal cortex of rats reared in isolation. 29 Sep 2009
• The peripheral antinociceptive effects of endomorphin-1 and kynurenic acid in the rat inflamed joint model. 29 Sep 2009
• Predator odor modulates auditory event-related potentials in mice. 21 Sep 2009
• Glutamate controls growth rate and branching of dopaminergic axons. 21 Sep 2009
• NMDA receptor phosphorylation at a site affected in schizophrenia controls synaptic and behavioral plasticity. 21 Sep 2009
• Encoding and decoding bursts by NMDA spikes in basal dendrites of layer 5 pyramidal neurons. 21 Sep 2009
• Vagal gustatory reflex circuits for intraoral food sorting behavior in the goldfish: cellular organization and neurotransmitters. 18 Sep 2009
• The role of granulocyte-colony stimulating factor (G-CSF) in the healthy brain: a characterization of G-CSF-deficient mice. 14 Sep 2009
• Acute psychiatric illness in a young woman: an unusual form of encephalitis. 5 Sep 2009
• Short-term synaptic plasticity in the nociceptive thalamic-anterior cingulate pathway. 2 Sep 2009
• Interaction of postsynaptic density protein-95 with NMDA receptors influences excitotoxicity in the yeast artificial chromosome mouse model of Huntington's disease. 31 Aug 2009
• BDNF and NT-3 increase excitatory input connectivity in rat hippocampal cultures. 30 Aug 2009
• Galantamine enhancement of long-term potentiation is mediated by calcium/calmodulin-dependent protein kinase II and protein kinase C activation. 30 Aug 2009
• Vasoactive intestinal peptide acts via multiple signal pathways to regulate hippocampal NMDA receptors and synaptic transmission. 30 Aug 2009
• Effects of chronic blockade of 5-HT(6) receptors on NMDA receptor subunits expression. 30 Aug 2009
• Central administration of minocycline and riluzole prevents morphine-induced tolerance in rats. 30 Aug 2009

See a longer list of these articles.

Technical information about 'Receptors, N-Methyl-D-Aspartate'

Definition: A class of ionotropic glutamate receptors characterized by affinity for N-methyl-D-aspartate. NMDA receptors have an allosteric binding site for glycine which must be occupied for the channel to open efficiently and a site within the channel itself to which magnesium ions bind in a voltage-dependent manner. The positive voltage dependence of channel conductance and the high permeability of the conducting channel to calcium ions (as well as to monovalent cations) are important in excitotoxicity and neuronal plasticity.

Registry Number: 0

Descriptor UI: D016194

Alternative terms: Receptors, N-Methyl-D-Aspartate; Receptors, N Methyl D Aspartate; N-Methyl-D-Aspartate Receptors; N Methyl D Aspartate Receptors; NMDA Receptors; Receptors, N-Methylaspartate; Receptors, N Methylaspartate; Receptors, NMDA; NMDA Receptor-Ionophore Complex; NMDA Receptor Ionophore Complex; N-Methylaspartate Receptors; N Methylaspartate Receptors;

Allowable Qualifiers: administration & dosage; analysis; antagonists & inhibitors; biosynthesis; blood; classification; deficiency; drug effects; genetics; history; immunology; isolation & purification; metabolism; physiology; radiation effects; therapeutic use; ultrastructure; chemistry; agonists;

Tree Number: D12.776.543.750.720.200.450.580;

Online Note: use RECEPTORS, N-METHYL-D-ASPARTATE to search RECEPTOR, N-METHYL-D-ASPARTATE & N-METHYL-D-ASPARTATE RECEPTOR 1991-92

History Note: 93; was RECEPTOR, N-METHYL-D-ASPARTATE 1991-92; N-METHYL-D-ASPARTATE RECEPTORS was N-METHYL-D-ASPARTATE RECEPTOR see RECEPTOR, N-METHYL-D-ASPARTATE 1991-92

Technical Notes: DF: RECEPT NMDA