Receptors, N-Methyl-D-Aspartate - Physiology
Research News and Information

Monday, November 23, 2009

Dual palmitoylation of NR2 subunits regulates NMDA receptor trafficking.

27 Oct 2009 Modification of NMDA receptor function and trafficking contributes to the regulation of synaptic transmission and is important for several forms of synaptic plasticity. Here, we report that NMDA receptor subunits NR2A and NR2B have two distinct ... Read more...

Cerebrospinal fluid of brain trauma patients inhibits in vitro neuronal network function via NMDA receptors.

29 Sep 2009 Neurological diseases frequently induce pathological changes of cerebrospinal fluid (CSF) that might secondarily influence brain activity, as the CSF-brain barrier is partially permeable. However, functional effects of CSF on neuronal network ... Read more...

Factors governing single-trial contextual fear conditioning in the weanling rat.

29 Sep 2009 Although contextual fear conditioning emerges later in development than explicit-cue fear conditioning, little is known about the stimulus parameters and biological substrates required at early ages. The authors adapted methods for investigating ... Read more...

Latest indexed articles for 'Receptors, N-Methyl-D-Aspartate - Physiology'

These are the very latest articles for this heading:

• Dual palmitoylation of NR2 subunits regulates NMDA receptor trafficking. 27 Oct 2009
• Cerebrospinal fluid of brain trauma patients inhibits in vitro neuronal network function via NMDA receptors. 29 Sep 2009
• Factors governing single-trial contextual fear conditioning in the weanling rat. 29 Sep 2009
• Appetitively motivated instrumental learning in SynGAP heterozygous knockout mice. 29 Sep 2009
• Control of NMDA receptor function by the NR2 subunit amino-terminal domain. 28 Sep 2009
• Acute neurobehavioral effects of toluene: involvement of dopamine and NMDA receptors. 14 Sep 2009
• Lack of kainic acid-induced gamma oscillations predicts subsequent CA1 excitotoxic cell death. 2 Sep 2009
• Reelin signaling antagonizes beta-amyloid at the synapse. 31 Aug 2009
• Dissociating beta-amyloid from alpha 7 nicotinic acetylcholine receptor by a novel therapeutic agent, S 24795, normalizes alpha 7 nicotinic acetylcholine and NMDA receptor function in Alzheimer's disease brain. 31 Aug 2009
• NMDA receptor GluN2B (GluR epsilon 2/NR2B) subunit is crucial for channel function, postsynaptic macromolecular organization, and actin cytoskeleton at hippocampal CA3 synapses. 31 Aug 2009
• [Anti-opioid action of glutamate-NMDA receptor systems underlying morphine analgesic tolerance] 30 Aug 2009
• Exposure to an enriched environment selectively increases the functional response of the pre-synaptic NMDA receptors which modulate noradrenaline release in mouse hippocampus. 30 Aug 2009
• Constraint on the number of synaptic inputs to a visual cortical neuron controls receptive field formation. 30 Aug 2009
• Effects of corticosterone and the beta-agonist isoproterenol on glutamate receptor-mediated synaptic currents in the rat basolateral amygdala. 25 Aug 2009
• N-methyl-D-aspartate receptor independent changes in expression of polysialic acid-neural cell adhesion molecule despite blockade of homosynaptic long-term potentiation and heterosynaptic long-term depression in the awake freely behaving rat dentate gyrus. 11 Aug 2009
• Modulation of synaptic transmission and plasticity by cell adhesion and repulsion molecules. 11 Aug 2009
• Molecular mechanisms underlying glutamatergic dysfunction in schizophrenia: therapeutic implications. 2 Aug 2009
• [Effects of memantine on convulsive reactions and sleep-waking cycle in Krushinskii-Molodkina strain rats with the inherited predisposition to audiogenic convulsions] 30 Jul 2009
• Positive and negative symptoms in schizophrenia: the NMDA receptor hypofunction hypothesis, neuregulin/ErbB4 and synapse regression. 30 Jul 2009
• NMDA receptors mediate an early up-regulation of brain-derived neurotrophic factor expression in substantia nigra in a rat model of presymptomatic Parkinson's disease. 30 Jul 2009

See a longer list of these articles.

Technical information about 'Receptors, N-Methyl-D-Aspartate'

Definition: A class of ionotropic glutamate receptors characterized by affinity for N-methyl-D-aspartate. NMDA receptors have an allosteric binding site for glycine which must be occupied for the channel to open efficiently and a site within the channel itself to which magnesium ions bind in a voltage-dependent manner. The positive voltage dependence of channel conductance and the high permeability of the conducting channel to calcium ions (as well as to monovalent cations) are important in excitotoxicity and neuronal plasticity.

Registry Number: 0

Descriptor UI: D016194

Alternative terms: Receptors, N-Methyl-D-Aspartate; Receptors, N Methyl D Aspartate; N-Methyl-D-Aspartate Receptors; N Methyl D Aspartate Receptors; NMDA Receptors; Receptors, N-Methylaspartate; Receptors, N Methylaspartate; Receptors, NMDA; NMDA Receptor-Ionophore Complex; NMDA Receptor Ionophore Complex; N-Methylaspartate Receptors; N Methylaspartate Receptors;

Allowable Qualifiers: administration & dosage; analysis; antagonists & inhibitors; biosynthesis; blood; classification; deficiency; drug effects; genetics; history; immunology; isolation & purification; metabolism; physiology; radiation effects; therapeutic use; ultrastructure; chemistry; agonists;

Tree Number: D12.776.543.750.720.200.450.580;

Online Note: use RECEPTORS, N-METHYL-D-ASPARTATE to search RECEPTOR, N-METHYL-D-ASPARTATE & N-METHYL-D-ASPARTATE RECEPTOR 1991-92

History Note: 93; was RECEPTOR, N-METHYL-D-ASPARTATE 1991-92; N-METHYL-D-ASPARTATE RECEPTORS was N-METHYL-D-ASPARTATE RECEPTOR see RECEPTOR, N-METHYL-D-ASPARTATE 1991-92

Technical Notes: DF: RECEPT NMDA