Receptors, Opioid, delta - Antagonists & inhibitors
Research News and Information

Monday, November 23, 2009

Delta opioid agonist [D-Ala2, D-Leu5] enkephalin (DADLE) reduced oxygen-glucose deprivation caused neuronal injury through the MAPK pathway.

16 Jul 2009 It has been demonstrated that [D-Ala2, D-Leu5] enkephalin (DADLE), a delta opioid agonist, protected neuron from hypoxic neuronal injury by activating the delta opioid receptor (DOR). However, whether DADLE can prevent neuronal injury induced by ... Read more...

Orally administered H-Dmt-Tic-Lys-NH-CH2-Ph (MZ-2), a potent mu/delta-opioid receptor antagonist, regulates obese-related factors in mice.

29 Jun 2009 Orally active dual mu-/delta-opioid receptor antagonist, H-Dmt-Tic-Lys-NH-CH(2)-Ph (MZ-2) was applied to study body weight gain, fat content, bone mineral density, serum insulin, cholesterol and glucose levels in female ob/ob (B6.V-Lep/J ... Read more...

Modulation of MDMA-induced behavioral and transcriptional effects by the delta opioid antagonist naltrindole in mice.

29 Jun 2009 The delta opioid system is involved in the behavioral effects of various drugs of abuse. However, only a few studies have focused on the possible interactions between the opioid system and the effects of 3,4-methylenedioxymethamphetamine (MDMA). In ... Read more...

Latest indexed articles for 'Receptors, Opioid, delta - Antagonists & inhibitors'

These are the very latest articles for this heading:

• Delta opioid agonist [D-Ala2, D-Leu5] enkephalin (DADLE) reduced oxygen-glucose deprivation caused neuronal injury through the MAPK pathway. 16 Jul 2009
• Orally administered H-Dmt-Tic-Lys-NH-CH2-Ph (MZ-2), a potent mu/delta-opioid receptor antagonist, regulates obese-related factors in mice. 29 Jun 2009
• Modulation of MDMA-induced behavioral and transcriptional effects by the delta opioid antagonist naltrindole in mice. 29 Jun 2009
• Acute and chronic fentanyl administration causes hyperalgesia independently of opioid receptor activity in mice. 22 Jun 2009
• Regulation of interleukin-1beta and interleukin-8 production by agonists of mu and delta opiate receptors in vitro. 9 Jun 2009
• Lack of effect of naltrindole on the spinal synergism of morphine and non-steroidal anti-inflammatory drugs (NSAIDS). 30 May 2009
• Morphine-6beta-glucuronide rapidly increases pain sensitivity independently of opioid receptor activity in mice and humans. 30 May 2009
• Simultaneous targeting of multiple opioid receptors: a strategy to improve side-effect profile. 25 May 2009
• Association of increased pain threshold by noise with central opioid neurons. 28 Apr 2009
• delta-Opioid receptor-stimulated Akt signaling in neuroblastoma x glioma (NG108-15) hybrid cells involves receptor tyrosine kinase-mediated PI3K activation. 8 Apr 2009
• [Intracellular mechanisms of opioidergic regulation of the myocardial function during normoxia and postischemic reperfusion] 30 Mar 2009
• Disruption of Cdk5-associated phosphorylation of residue threonine-161 of the delta-opioid receptor: impaired receptor function and attenuated morphine antinociceptive tolerance. 16 Mar 2009
• Delta opioid receptor-mediated immunoregulatory role of methionine-enkephalin in freshwater teleost Channa punctatus (Bloch.). 11 Mar 2009
• Activation of peripheral delta2 opioid receptors increases cardiac tolerance to ischemia/reperfusion injury Involvement of protein kinase C, NO-synthase, KATP channels and the autonomic nervous system. 22 Feb 2009
• Neutral antagonist activity of naltrexone and 6beta-naltrexol in naïve and opioid-dependent C6 cells expressing a mu-opioid receptor. 11 Feb 2009
• Comparison with naloxone of two dynorphin A analogues with K- and delta-opioid antagonist activity. 30 Dec 2008
• Protection conferred by Corticotropin-releasing hormone in rat primary cortical neurons against chemical ischemia involves opioid receptor activation. 28 Dec 2008
• Docking studies suggest ligand-specific delta-opioid receptor conformations. 2 Dec 2008
• Stimulation of delta opioid receptors located in substantia nigra reticulata but not globus pallidus or striatum restores motor activity in 6-hydroxydopamine lesioned rats: new insights into the role of delta receptors in parkinsonism. 29 Nov 2008
• Novel role for the delta-opioid receptor in hypoxic preconditioning in rat retinas. 26 Nov 2008

See a longer list of these articles.

Technical information about 'Receptors, Opioid, delta'

Definition: A class of opioid receptors recognized by its pharmacological profile. Delta opioid receptors bind endorphins and enkephalins with approximately equal affinity and have less affinity for dynorphins.

Registry Number: 0

Descriptor UI: D017465

Alternative terms: Receptors, Opioid, delta; Opioid Receptors, delta; delta Opioid Receptors; Receptors, delta Opioid; Receptors, delta; delta Receptor; Receptor, delta; delta Receptors; delta Opioid Receptor; Opioid Receptor, delta; Receptor, delta Opioid;

Allowable Qualifiers: administration & dosage; analysis; antagonists & inhibitors; biosynthesis; blood; classification; deficiency; drug effects; genetics; history; immunology; isolation & purification; metabolism; physiology; radiation effects; therapeutic use; ultrastructure; chemistry; agonists;

Tree Number: D12.776.543.750.100.620.200; D12.776.543.750.720.600.610.200; D12.776.543.750.750.555.610.200;

Online Note: use RECEPTORS, OPIOID, DELTA to search RECEPTORS, DELTA 1993; use RECEPTORS, OPIOID, DELTA (NM) to search DELTA RECEPTOR 1982-92

History Note: 94; was RECEPTORS, DELTA 1993; was DELTA RECEPTOR (NM) 1982-92

Technical Notes: opioid receptors; DF: RECEPT DELTA