Receptors, Opioid, delta - Genetics
Research News and Information

Sunday, November 22, 2009

[Genetic polymorphisms and human sensitivity to pain and opioids]

30 Aug 2009 It has been known widely that sensitivity to pain and opioid analgesics varies widely among individual subjects. Because of this variability, a dose of an opioid analgesic that can produce satisfactory pain relief without adverse effects in some ... Read more...

Acute and chronic fentanyl administration causes hyperalgesia independently of opioid receptor activity in mice.

22 Jun 2009 Although mu-receptor opioids are clinically important analgesics, they can also paradoxically cause hyperalgesia independently of opioid receptor activity, presumably via the action of neuroexcitatory glucoronide metabolites. However, it is unknown ... Read more...

Morphine-6beta-glucuronide rapidly increases pain sensitivity independently of opioid receptor activity in mice and humans.

30 May 2009 BACKGROUND: Previous data indicate that morphine-6beta-glucuronide (M6G), a morphine metabolite with analgesic properties, can paradoxically increase pain sensitivity in mice and humans. The authors tested mice and humans for M6G hyperalgesia and ... Read more...

Latest indexed articles for 'Receptors, Opioid, delta - Genetics'

These are the very latest articles for this heading:

• [Genetic polymorphisms and human sensitivity to pain and opioids] 30 Aug 2009
• Acute and chronic fentanyl administration causes hyperalgesia independently of opioid receptor activity in mice. 22 Jun 2009
• Pleiotropic effects of morphine-6beta-glucuronide. 30 May 2009
• Morphine-6beta-glucuronide rapidly increases pain sensitivity independently of opioid receptor activity in mice and humans. 30 May 2009
• Differential modulation of mu- and delta-opioid receptor agonists by endogenous RGS4 protein in SH-SY5Y cells. 3 May 2009
• In vivo delta opioid receptor internalization controls behavioral effects of agonists. 29 Apr 2009
• Disruption of Cdk5-associated phosphorylation of residue threonine-161 of the delta-opioid receptor: impaired receptor function and attenuated morphine antinociceptive tolerance. 16 Mar 2009
• Mu and delta opioid receptors oppositely regulate motor impulsivity in the signaled nose poke task. 7 Feb 2009
• Can we identify genes for alcohol consumption in samples ascertained for heterogeneous purposes? 20 Jan 2009
• The pro-nociceptive effects of remifentanil or surgical injury in mice are associated with a decrease in delta-opioid receptor mRNA levels: Prevention of the nociceptive response by on-site delivery of enkephalins. 3 Dec 2008
• Association between human opioid receptor genes polymorphisms and pressure pain sensitivity in females*. 29 Nov 2008
• The expression of genes coding for opioid precursors, opioid receptors, beta-LH subunit and GnRH receptor in the anterior pituitary of cyclic gilts. 29 Nov 2008
• Phe27Cys polymorphism alters the maturation and subcellular localization of the human delta opioid receptor. 27 Oct 2008
• Cloning of opioid receptors in common carp (Cyprinus carpio L.) and their involvement in regulation of stress and immune response. 15 Oct 2008
• In vivo trafficking of endogenous opioid receptors. 3 Oct 2008
• Multiple OPR genes influence personality traits in substance dependent and healthy subjects in two American populations. 3 Oct 2008
• Food deprivation increases the mRNA expression of micro-opioid receptors in the ventral medial hypothalamus and arcuate nucleus. Sep 2008
• Continuous delta-opioid receptor activation reduces neuronal voltage-gated sodium channel (NaV1.7) levels through activation of protein kinase C in painful diabetic neuropathy. 23 Jun 2008
• Noradrenergic and opioidergic alterations in neuropathy in different rat strains. 18 Jun 2008
• Relationship of spinal dynorphin neurons to delta-opioid receptors and estrogen receptor alpha: anatomical basis for ovarian sex steroid opioid antinociception. 7 Jun 2008

See a longer list of these articles.

Technical information about 'Receptors, Opioid, delta'

Definition: A class of opioid receptors recognized by its pharmacological profile. Delta opioid receptors bind endorphins and enkephalins with approximately equal affinity and have less affinity for dynorphins.

Registry Number: 0

Descriptor UI: D017465

Alternative terms: Receptors, Opioid, delta; Opioid Receptors, delta; delta Opioid Receptors; Receptors, delta Opioid; Receptors, delta; delta Receptor; Receptor, delta; delta Receptors; delta Opioid Receptor; Opioid Receptor, delta; Receptor, delta Opioid;

Allowable Qualifiers: administration & dosage; analysis; antagonists & inhibitors; biosynthesis; blood; classification; deficiency; drug effects; genetics; history; immunology; isolation & purification; metabolism; physiology; radiation effects; therapeutic use; ultrastructure; chemistry; agonists;

Tree Number: D12.776.543.750.100.620.200; D12.776.543.750.720.600.610.200; D12.776.543.750.750.555.610.200;

Online Note: use RECEPTORS, OPIOID, DELTA to search RECEPTORS, DELTA 1993; use RECEPTORS, OPIOID, DELTA (NM) to search DELTA RECEPTOR 1982-92

History Note: 94; was RECEPTORS, DELTA 1993; was DELTA RECEPTOR (NM) 1982-92

Technical Notes: opioid receptors; DF: RECEPT DELTA