Receptors, Opioid, delta
Research News and Information

Sunday, November 22, 2009

Acute methadone treatment reduces myocardial infarct size via the delta-opioid receptor in rats during reperfusion.

30 Oct 2009 BACKGROUND: Methadone is an opioid agonist often given to manage acute and chronic pain. We sought to determine whether methadone compared with morphine dose dependently reduces myocardial infarct size (IS) and whether the mechanism is delta-opioid ... Read more...

Protein kinase C mediates the synergistic interaction between agonists acting at alpha2-adrenergic and delta-opioid receptors in spinal cord.

19 Oct 2009 Coactivation of spinal alpha(2)-adrenergic receptors (ARs) and opioid receptors produces antinociceptive synergy. Antinociceptive synergy between intrathecally administered alpha(2)AR and opioid agonists is well documented, but the mechanism ... Read more...

Spirocyclic delta opioid receptor agonists for the treatment of pain: discovery of N,N-diethyl-3-hydroxy-4-(spiro[chromene-2,4'-piperidine]-4-yl) benzamide (ADL5747).

22 Sep 2009 Selective, nonpeptidic delta opioid receptor agonists have been the subject of great interest as potential novel analgesic agents. The discoveries of BW373U86 (1) and SNC80 (2) contributed to the rapid expansion of research in this field. However, ... Read more...

Latest indexed articles for 'Receptors, Opioid, delta'

These are the very latest articles for this heading:

• Acute methadone treatment reduces myocardial infarct size via the delta-opioid receptor in rats during reperfusion. 30 Oct 2009
• Protein kinase C mediates the synergistic interaction between agonists acting at alpha2-adrenergic and delta-opioid receptors in spinal cord. 19 Oct 2009
• Spirocyclic delta opioid receptor agonists for the treatment of pain: discovery of N,N-diethyl-3-hydroxy-4-(spiro[chromene-2,4'-piperidine]-4-yl) benzamide (ADL5747). 22 Sep 2009
• [Genetic polymorphisms and human sensitivity to pain and opioids] 30 Aug 2009
• Roles of opioid receptor subtypes in mediating alcohol-seeking induced by discrete cues and context. Aug 2009
• Delta opioid agonist [D-Ala2, D-Leu5] enkephalin (DADLE) reduced oxygen-glucose deprivation caused neuronal injury through the MAPK pathway. 16 Jul 2009
• Aerobic oxidation of indolomorphinan without the 4,5-epoxy bridge and subsequent rearrangement of the oxidation product to spiroindolinonyl-C-normorphinan derivative. Jul 2009
• Orally administered H-Dmt-Tic-Lys-NH-CH2-Ph (MZ-2), a potent mu/delta-opioid receptor antagonist, regulates obese-related factors in mice. 29 Jun 2009
• Modulation of MDMA-induced behavioral and transcriptional effects by the delta opioid antagonist naltrindole in mice. 29 Jun 2009
• Protein kinase C mediates the effects of delta-opioid receptor stimulation on survival and apoptosis in neonatal cardiomyocytes cultured in serum-deprived condition. 29 Jun 2009
• Kappa and delta opioid receptor signaling is augmented in the failing heart. 28 Jun 2009
• Acute and chronic fentanyl administration causes hyperalgesia independently of opioid receptor activity in mice. 22 Jun 2009
• Role of preoptic opioid receptors in the body temperature reduction during hypoxia. 19 Jun 2009
• Solid-phase synthetic strategy and bioevaluation of a labeled delta-opioid receptor ligand Dmt-Tic-Lys for in vivo imaging. 16 Jun 2009
• Dissociation of the opioid receptor mechanisms that control mechanical and heat pain. 10 Jun 2009
• Mu and delta opioid receptors diverge. 10 Jun 2009
• Differential effect of membrane cholesterol removal on mu- and delta-opioid receptors: a parallel comparison of acute and chronic signaling to adenylyl cyclase. 9 Jun 2009
• Regulation of interleukin-1beta and interleukin-8 production by agonists of mu and delta opiate receptors in vitro. 9 Jun 2009
• Lack of effect of naltrindole on the spinal synergism of morphine and non-steroidal anti-inflammatory drugs (NSAIDS). 30 May 2009
• Pleiotropic effects of morphine-6beta-glucuronide. 30 May 2009

See a longer list of these articles.

Technical information about 'Receptors, Opioid, delta'

Definition: A class of opioid receptors recognized by its pharmacological profile. Delta opioid receptors bind endorphins and enkephalins with approximately equal affinity and have less affinity for dynorphins.

Registry Number: 0

Descriptor UI: D017465

Alternative terms: Receptors, Opioid, delta; Opioid Receptors, delta; delta Opioid Receptors; Receptors, delta Opioid; Receptors, delta; delta Receptor; Receptor, delta; delta Receptors; delta Opioid Receptor; Opioid Receptor, delta; Receptor, delta Opioid;

Allowable Qualifiers: administration & dosage; analysis; antagonists & inhibitors; biosynthesis; blood; classification; deficiency; drug effects; genetics; history; immunology; isolation & purification; metabolism; physiology; radiation effects; therapeutic use; ultrastructure; chemistry; agonists;

Tree Number: D12.776.543.750.100.620.200; D12.776.543.750.720.600.610.200; D12.776.543.750.750.555.610.200;

Online Note: use RECEPTORS, OPIOID, DELTA to search RECEPTORS, DELTA 1993; use RECEPTORS, OPIOID, DELTA (NM) to search DELTA RECEPTOR 1982-92

History Note: 94; was RECEPTORS, DELTA 1993; was DELTA RECEPTOR (NM) 1982-92

Technical Notes: opioid receptors; DF: RECEPT DELTA