Receptors, Opioid, kappa - Drug effects
Research News and Information

Monday, November 23, 2009

Structure-based design, synthesis, and biochemical and pharmacological characterization of novel salvinorin A analogues as active state probes of the kappa-opioid receptor.

26 Jul 2009 Salvinorin A, the most potent naturally occurring hallucinogen, has attracted an increasing amount of attention since the kappa-opioid receptor (KOR) was identified as its principal molecular target by us [Roth, B. L., et al. (2002) Proc. Natl. ... Read more...

Morphine-6beta-glucuronide rapidly increases pain sensitivity independently of opioid receptor activity in mice and humans.

30 May 2009 BACKGROUND: Previous data indicate that morphine-6beta-glucuronide (M6G), a morphine metabolite with analgesic properties, can paradoxically increase pain sensitivity in mice and humans. The authors tested mice and humans for M6G hyperalgesia and ... Read more...

Peptide kappa opioid receptor ligands: potential for drug development.

7 May 2009 While narcotic analgesics such as morphine, which act preferentially through mu opioid receptors, remain the gold standard in the treatment of severe pain, their use is limited by detrimental liabilities such as respiratory depression and drug ... Read more...

Latest indexed articles for 'Receptors, Opioid, kappa - Drug effects'

These are the very latest articles for this heading:

• Neuroscience. Salvia on schedule. 30 Jul 2009
• Structure-based design, synthesis, and biochemical and pharmacological characterization of novel salvinorin A analogues as active state probes of the kappa-opioid receptor. 26 Jul 2009
• Morphine-6beta-glucuronide rapidly increases pain sensitivity independently of opioid receptor activity in mice and humans. 30 May 2009
• Peptide kappa opioid receptor ligands: potential for drug development. 7 May 2009
• Neuropeptide VF-associated satiety involves mu and kappa but not delta subtypes of opioid receptors in chicks. 12 Mar 2009
• Hypertensive state, independent of hypertrophy, exhibits an attenuated decrease in systolic function on cardiac kappa-opioid receptor stimulation. 28 Jan 2009
• Unconditioned behavioral effects of the powerful kappa-opioid hallucinogen salvinorin A in nonhuman primates: fast onset and entry into cerebrospinal fluid. 8 Nov 2008
• Effects of atypical kappa-opioid receptor agonists on intrathecal morphine-induced itch and analgesia in primates. 6 Oct 2008
• In vivo trafficking of endogenous opioid receptors. 3 Oct 2008
• Micro/kappa opioid interactions in rhesus monkeys: implications for analgesia and abuse liability. 29 Sep 2008
• Involvement of kappa opioid receptors in the inhibition of receptor desensitization and PKC activation induced by repeated morphine treatment. 30 Aug 2008
• Modulation of opioids via protection of anandamide degradation by fatty acid amide hydrolase. 18 Aug 2008
• High doses of processed Aconiti tuber inhibit the acute but potentiate the chronic antinociception of morphine. 16 Jul 2008
• Genetic and early environmental contributions to alcohol's aversive and physiological effects. 27 Jun 2008
• Stress-induced reinstatement of cocaine seeking is mediated by the kappa opioid system. 23 Jun 2008
• Differential involvement of opioidergic and serotonergic systems in the antinociceptive activity of N-arachidonoyl-phenolamine (AM404) in the rat: comparison with paracetamol. 9 Apr 2008
• Opioid pharmacology. 28 Feb 2008
• Interaction of memantine and ketamine in morphine- and pentazocine-induced antinociception in mice. 28 Feb 2008
• Toward a structure-based model of salvinorin A recognition of the kappa-opioid receptor. 21 Feb 2008
• Acute and chronic heroin dependence in mice: contribution of opioid and excitatory amino acid receptors. 17 Feb 2008

See a longer list of these articles.

Technical information about 'Receptors, Opioid, kappa'

Definition: A class of opioid receptors recognized by its pharmacological profile. Kappa opioid receptors bind dynorphins with a higher affinity than endorphins which are themselves preferred to enkephalins.

Registry Number: 0

Descriptor UI: D017473

Alternative terms: Receptors, Opioid, kappa; Opioid Receptors, kappa; kappa Opioid Receptors; Receptors, kappa Opioid; Receptors, kappa; kappa Receptor; Receptor, kappa; kappa Receptors; kappa Opioid Receptor; Opioid Receptor, kappa; Receptor, kappa Opioid;

Allowable Qualifiers: administration & dosage; analysis; antagonists & inhibitors; biosynthesis; blood; classification; deficiency; drug effects; genetics; history; immunology; isolation & purification; metabolism; physiology; radiation effects; therapeutic use; ultrastructure; chemistry; agonists;

Tree Number: D12.776.543.750.100.620.400; D12.776.543.750.720.600.610.400; D12.776.543.750.750.555.610.400;

Online Note: use RECEPTORS, OPIOID, KAPPA to search RECEPTORS, KAPPA 1993; use RECEPTORS, OPIOID, KAPPA (NM) to search KAPPA RECEPTOR 1980-92

History Note: 94; was RECEPTORS, KAPPA 1993; was KAPPA RECEPTOR (NM) 1980-92

Technical Notes: opioid receptors found in the anterior pituitary & substantia nigra; DF: RECEPT KAPPA