Receptors, Opioid, kappa - Genetics
Research News and Information

Sunday, November 22, 2009

Structure-based design, synthesis, and biochemical and pharmacological characterization of novel salvinorin A analogues as active state probes of the kappa-opioid receptor.

26 Jul 2009 Salvinorin A, the most potent naturally occurring hallucinogen, has attracted an increasing amount of attention since the kappa-opioid receptor (KOR) was identified as its principal molecular target by us [Roth, B. L., et al. (2002) Proc. Natl. ... Read more...

High-level production and characterization of a G-protein coupled receptor signaling complex.

21 Jul 2009 Elucidation of the molecular details of signal transduction through G-protein coupled receptors (GPCRs) awaits the solution of high-resolution structures of the receptor species involved in passing the extracellular information across the plasma ... Read more...

Prodynorphin gene deficiency potentiates nalbuphine-induced behavioral sensitization and withdrawal syndrome in mice.

23 Jun 2009 Dynorphin is the presumed endogenous ligand for the kappa-opioid receptor. The dynorphin gene may play a role in psychotropic agent-mediated behavioral changes via dopaminergic modulation. Therefore, in this study, possible involvement of the ... Read more...

Latest indexed articles for 'Receptors, Opioid, kappa - Genetics'

These are the very latest articles for this heading:

• Structure-based design, synthesis, and biochemical and pharmacological characterization of novel salvinorin A analogues as active state probes of the kappa-opioid receptor. 26 Jul 2009
• High-level production and characterization of a G-protein coupled receptor signaling complex. 21 Jul 2009
• Prodynorphin gene deficiency potentiates nalbuphine-induced behavioral sensitization and withdrawal syndrome in mice. 23 Jun 2009
• Acute and chronic fentanyl administration causes hyperalgesia independently of opioid receptor activity in mice. 22 Jun 2009
• Pleiotropic effects of morphine-6beta-glucuronide. 30 May 2009
• Morphine-6beta-glucuronide rapidly increases pain sensitivity independently of opioid receptor activity in mice and humans. 30 May 2009
• Endogenous kappa opioid activation mediates stress-induced deficits in learning and memory. 30 Mar 2009
• Cell-specific loss of kappa-opioid receptors in oligodendrocytes of the dysmyelinating jimpy mouse. 22 Dec 2008
• Association between human opioid receptor genes polymorphisms and pressure pain sensitivity in females*. 29 Nov 2008
• The expression of genes coding for opioid precursors, opioid receptors, beta-LH subunit and GnRH receptor in the anterior pituitary of cyclic gilts. 29 Nov 2008
• GEC1-kappa opioid receptor binding involves hydrophobic interactions: GEC1 has chaperone-like effect. 9 Nov 2008
• Cloning of opioid receptors in common carp (Cyprinus carpio L.) and their involvement in regulation of stress and immune response. 15 Oct 2008
• In vivo trafficking of endogenous opioid receptors. 3 Oct 2008
• Multiple OPR genes influence personality traits in substance dependent and healthy subjects in two American populations. 3 Oct 2008
• Opioidergic projections to sleep-active neurons in the ventrolateral preoptic nucleus. 22 Sep 2008
• Food deprivation increases the mRNA expression of micro-opioid receptors in the ventral medial hypothalamus and arcuate nucleus. Sep 2008
• Involvement of kappa-opioid receptors in visceral nociception in mice. 12 Jul 2008
• Genetic and early environmental contributions to alcohol's aversive and physiological effects. 27 Jun 2008
• Stress-induced reinstatement of cocaine seeking is mediated by the kappa opioid system. 23 Jun 2008
• Differential effects of opioid agonists on G protein expression in CHO cells expressing cloned human opioid receptors. 2 Jun 2008

See a longer list of these articles.

Technical information about 'Receptors, Opioid, kappa'

Definition: A class of opioid receptors recognized by its pharmacological profile. Kappa opioid receptors bind dynorphins with a higher affinity than endorphins which are themselves preferred to enkephalins.

Registry Number: 0

Descriptor UI: D017473

Alternative terms: Receptors, Opioid, kappa; Opioid Receptors, kappa; kappa Opioid Receptors; Receptors, kappa Opioid; Receptors, kappa; kappa Receptor; Receptor, kappa; kappa Receptors; kappa Opioid Receptor; Opioid Receptor, kappa; Receptor, kappa Opioid;

Allowable Qualifiers: administration & dosage; analysis; antagonists & inhibitors; biosynthesis; blood; classification; deficiency; drug effects; genetics; history; immunology; isolation & purification; metabolism; physiology; radiation effects; therapeutic use; ultrastructure; chemistry; agonists;

Tree Number: D12.776.543.750.100.620.400; D12.776.543.750.720.600.610.400; D12.776.543.750.750.555.610.400;

Online Note: use RECEPTORS, OPIOID, KAPPA to search RECEPTORS, KAPPA 1993; use RECEPTORS, OPIOID, KAPPA (NM) to search KAPPA RECEPTOR 1980-92

History Note: 94; was RECEPTORS, KAPPA 1993; was KAPPA RECEPTOR (NM) 1980-92

Technical Notes: opioid receptors found in the anterior pituitary & substantia nigra; DF: RECEPT KAPPA