Receptors, Opioid, kappa
Research News and Information

Monday, November 23, 2009

Design, synthesis, and pharmacological activities of dynorphin A analogues cyclized by ring-closing metathesis.

22 Sep 2009 Dynorphin A (Dyn A) is an endogenous ligand for kappa opioid receptors. To restrict the conformational mobility, we synthesized several cyclic Dyn A-(1-11)NH(2) analogues on solid phase utilizing ring-closing metathesis (RCM) between the side chains ... Read more...

Analgesic efficacy of peripheral kappa-opioid receptor agonist CR665 compared to oxycodone in a multi-modal, multi-tissue experimental human pain model: selective effect on visceral pain.

30 Aug 2009 BACKGROUND: Peripherally selective opioids may be beneficial in visceral pain management due to absence of centrally mediated side effects. The objectives of this study were: (1) to assess the effects of a peripherally selective tetrapeptide ... Read more...

Blockade of ethanol reward by the kappa opioid receptor agonist U50,488H.

30 Jul 2009 Alcoholism is a pervasive social problem, and thus understanding factors that regulate alcohol (ethanol) reward is important for designing effective therapies. One putative regulatory system includes the kappa opioid receptor (KOR) and its ... Read more...

Latest indexed articles for 'Receptors, Opioid, kappa'

These are the very latest articles for this heading:

• Design, synthesis, and pharmacological activities of dynorphin A analogues cyclized by ring-closing metathesis. 22 Sep 2009
• Analgesic efficacy of peripheral kappa-opioid receptor agonist CR665 compared to oxycodone in a multi-modal, multi-tissue experimental human pain model: selective effect on visceral pain. 30 Aug 2009
• Blockade of ethanol reward by the kappa opioid receptor agonist U50,488H. 30 Jul 2009
• Neuroscience. Salvia on schedule. 30 Jul 2009
• The effect of kappa-opioid receptor agonists on tetrodotoxin-resistant sodium channels in primary sensory neurons. 30 Jul 2009
• Structure-based design, synthesis, and biochemical and pharmacological characterization of novel salvinorin A analogues as active state probes of the kappa-opioid receptor. 26 Jul 2009
• High-level production and characterization of a G-protein coupled receptor signaling complex. 21 Jul 2009
• Synthesis and characterizations of novel quinoline derivatives having mixed ligand activities at the kappa and mu receptors: Potential therapeutic efficacy against morphine dependence. 16 Jul 2009
• Synthetic studies of neoclerodane diterpenes from Salvia divinorum: role of the furan in affinity for opioid receptors. 12 Jul 2009
• The kappa-opiate receptor impacts the pathophysiology and behavior of substance use. 29 Jun 2009
• Distribution of kappa-opioid receptor in the pulmonary artery and its changes during hypoxia. 29 Jun 2009
• Kappa and delta opioid receptor signaling is augmented in the failing heart. 28 Jun 2009
• Synthesis and opioid receptor activity of indolopropellanes. 28 Jun 2009
• Prodynorphin gene deficiency potentiates nalbuphine-induced behavioral sensitization and withdrawal syndrome in mice. 23 Jun 2009
• Acute and chronic fentanyl administration causes hyperalgesia independently of opioid receptor activity in mice. 22 Jun 2009
• Role of preoptic opioid receptors in the body temperature reduction during hypoxia. 19 Jun 2009
• Inhibitory effect of lidocaine on pain and itch using formalin-induced nociception and 5'-guanidinonaltrindole-induced scratching models in mice: behavioral and neuroanatomical evidence. 19 Jun 2009
• Identification, structure-activity relationships and molecular modeling of potent triamine and piperazine opioid ligands. 19 Jun 2009
• The contribution of serotonin 1A receptors to kappa opioid immunosuppression. 9 Jun 2009
• Kappa-opioid ligands in the study and treatment of mood disorders. 31 May 2009

See a longer list of these articles.

Technical information about 'Receptors, Opioid, kappa'

Definition: A class of opioid receptors recognized by its pharmacological profile. Kappa opioid receptors bind dynorphins with a higher affinity than endorphins which are themselves preferred to enkephalins.

Registry Number: 0

Descriptor UI: D017473

Alternative terms: Receptors, Opioid, kappa; Opioid Receptors, kappa; kappa Opioid Receptors; Receptors, kappa Opioid; Receptors, kappa; kappa Receptor; Receptor, kappa; kappa Receptors; kappa Opioid Receptor; Opioid Receptor, kappa; Receptor, kappa Opioid;

Allowable Qualifiers: administration & dosage; analysis; antagonists & inhibitors; biosynthesis; blood; classification; deficiency; drug effects; genetics; history; immunology; isolation & purification; metabolism; physiology; radiation effects; therapeutic use; ultrastructure; chemistry; agonists;

Tree Number: D12.776.543.750.100.620.400; D12.776.543.750.720.600.610.400; D12.776.543.750.750.555.610.400;

Online Note: use RECEPTORS, OPIOID, KAPPA to search RECEPTORS, KAPPA 1993; use RECEPTORS, OPIOID, KAPPA (NM) to search KAPPA RECEPTOR 1980-92

History Note: 94; was RECEPTORS, KAPPA 1993; was KAPPA RECEPTOR (NM) 1980-92

Technical Notes: opioid receptors found in the anterior pituitary & substantia nigra; DF: RECEPT KAPPA