Receptors, Opioid, mu - Antagonists & inhibitors
Research News and Information

Monday, November 23, 2009

Synthesis and characterizations of novel quinoline derivatives having mixed ligand activities at the kappa and mu receptors: Potential therapeutic efficacy against morphine dependence.

16 Jul 2009 Based on an established 3D pharmacophore, a series of quinoline derivatives were synthesized. The opioidergic properties of these compounds were determined by a competitive binding assay using (125)I-Dynorphine, (3)H-DAMGO and (125)I-DADLE for ... Read more...

Orally administered H-Dmt-Tic-Lys-NH-CH2-Ph (MZ-2), a potent mu/delta-opioid receptor antagonist, regulates obese-related factors in mice.

29 Jun 2009 Orally active dual mu-/delta-opioid receptor antagonist, H-Dmt-Tic-Lys-NH-CH(2)-Ph (MZ-2) was applied to study body weight gain, fat content, bone mineral density, serum insulin, cholesterol and glucose levels in female ob/ob (B6.V-Lep/J ... Read more...

Pharmacology of sedative-analgesic agents: dexmedetomidine, remifentanil, ketamine, volatile anesthetics, and the role of peripheral mu antagonists.

29 Jun 2009 In this article, the authors discuss the pharmacology of sedative-analgesic agents like dexmedetomidine, remifentanil, ketamine, and volatile anesthetics. Dexmedetomidine is a highly selective alpha-2 agonist that provides anxiolysis and cooperative ... Read more...

Latest indexed articles for 'Receptors, Opioid, mu - Antagonists & inhibitors'

These are the very latest articles for this heading:

• Synthesis and characterizations of novel quinoline derivatives having mixed ligand activities at the kappa and mu receptors: Potential therapeutic efficacy against morphine dependence. 16 Jul 2009
• Orally administered H-Dmt-Tic-Lys-NH-CH2-Ph (MZ-2), a potent mu/delta-opioid receptor antagonist, regulates obese-related factors in mice. 29 Jun 2009
• Pharmacology of sedative-analgesic agents: dexmedetomidine, remifentanil, ketamine, volatile anesthetics, and the role of peripheral mu antagonists. 29 Jun 2009
• Acute and chronic fentanyl administration causes hyperalgesia independently of opioid receptor activity in mice. 22 Jun 2009
• Role of the opioid system in incentive downshift situations. 12 Jun 2009
• Regulation of interleukin-1beta and interleukin-8 production by agonists of mu and delta opiate receptors in vitro. 9 Jun 2009
• Prokinetic drugs for feed intolerance in critical illness: current and potential therapies. 30 May 2009
• Morphine-6beta-glucuronide rapidly increases pain sensitivity independently of opioid receptor activity in mice and humans. 30 May 2009
• Acute effects of morphine on distinct forms of impulsive behavior in rats. 11 May 2009
• Activating mu-opioid receptors in the lateral parabrachial nucleus increases c-Fos expression in forebrain areas associated with caloric regulation, reward and cognition. 3 May 2009
• Nascent structure-activity relationship study of a diastereomeric series of kappa opioid receptor antagonists derived from CJ-15,208. May 2009
• A brief report of student research: mechanism of analgesic effect and efficacy and anesthesia interactions of kava in the male Sprague-Dawley rat. 29 Apr 2009
• Association of increased pain threshold by noise with central opioid neurons. 28 Apr 2009
• The effects of repeated opioid administration on locomotor activity: I. Opposing actions of mu and kappa receptors. 27 Apr 2009
• Centralization of noxious stimulus-induced analgesia (NSIA) is related to activity at inhibitory synapses in the spinal cord. 14 Apr 2009
• Shadows across mu-Star? Constitutively active mu-opioid receptors revisited. 30 Mar 2009
• Pharmacological management of postoperative ileus. 30 Mar 2009
• 14 beta-O-cinnamoylnaltrexone and related dihydrocodeinones are mu opioid receptor partial agonists with predominant antagonist activity. 24 Mar 2009
• Seizure activity involved in the up-regulation of BDNF mRNA expression by activation of central mu opioid receptors. 17 Mar 2009
• Ethanol-induced social facilitation in adolescent rats: role of endogenous activity at mu opioid receptors. 17 Mar 2009

See a longer list of these articles.

Technical information about 'Receptors, Opioid, mu'

Definition: A class of opioid receptors recognized by its pharmacological profile. Mu opioid receptors bind, in decreasing order of affinity, endorphins, dynorphins, met-enkephalin, and leu-enkephalin. They have also been shown to be molecular receptors for morphine.

Registry Number: 0

Descriptor UI: D017450

Alternative terms: Receptors, Opioid, mu; Opioid Receptors, mu; mu Opioid Receptors; Receptors, mu Opioid; Receptors, mu; mu Receptor; Receptor, mu; mu Receptors; mu Opioid Receptor; Opioid Receptor, mu; Receptor, mu Opioid; Morphine Receptor; Receptor, Morphine; Receptors, Morphine; Morphine Receptors;

Allowable Qualifiers: administration & dosage; analysis; antagonists & inhibitors; biosynthesis; blood; classification; deficiency; drug effects; genetics; history; immunology; isolation & purification; metabolism; physiology; radiation effects; therapeutic use; ultrastructure; chemistry; agonists;

Tree Number: D12.776.543.750.100.620.550; D12.776.543.750.720.600.610.550; D12.776.543.750.750.555.610.550;

Online Note: use RECEPTORS, OPIOID, MU to search RECEPTORS, MU 1993; use RECEPTORS, OPIOID, MU (NM) to search MU RECEPTOR 1981-92; use RECEPTORS, OPIOID to search MORPHINE RECEPTORS & RECEPTORS, MORPHINE 1977-94

History Note: 94; was RECEPTORS, MU 1993; was MU RECEPTOR (NM) 1981-92; MORPHINE RECEPTORS & RECEPTORS, MORPHINE were see RECEPTORS, OPIOID 1977-94

Technical Notes: opioid receptors found in the hypothalamus; DF: RECEPT MU