Receptors, Opioid, mu - Drug effects
Research News and Information

Monday, November 23, 2009

mu-opioid receptor-stimulated synthesis of reactive oxygen species is mediated via phospholipase D2.

8 Jun 2009 We have recently shown that the activation of the rat mu-opioid receptor (MOPr, also termed MOR1) by the mu-agonist [D-Ala(2), Me Phe(4), Glyol(5)]enkephalin (DAMGO) leads to an increase in phospholipase D2 (PLD2) activity and an induction of ... Read more...

Ovarian steroids alter mu opioid receptor trafficking in hippocampal parvalbumin GABAergic interneurons.

4 Jun 2009 The endogenous hippocampal opioid systems are implicated in learning associated with drug use. Recently, we showed that ovarian hormones regulate enkephalin levels in the mossy fiber pathway. This pathway overlaps with parvalbumin (PARV)-basket ... Read more...

Morphine-induced physiological and behavioral responses in mice lacking G protein-coupled receptor kinase 6.

Jun 2009 G protein-coupled receptor kinases (GRKs) are a family of intracellular proteins that desensitize and regulate the responsiveness of G protein-coupled receptors (GPCRs). In the present study, we assessed the contribution of GRK6 to the regulation ... Read more...

Latest indexed articles for 'Receptors, Opioid, mu - Drug effects'

These are the very latest articles for this heading:

• mu-opioid receptor-stimulated synthesis of reactive oxygen species is mediated via phospholipase D2. 8 Jun 2009
• Ovarian steroids alter mu opioid receptor trafficking in hippocampal parvalbumin GABAergic interneurons. 4 Jun 2009
• Morphine-induced physiological and behavioral responses in mice lacking G protein-coupled receptor kinase 6. Jun 2009
• Morphine-6beta-glucuronide rapidly increases pain sensitivity independently of opioid receptor activity in mice and humans. 30 May 2009
• A brief report of student research: mechanism of analgesic effect and efficacy and anesthesia interactions of kava in the male Sprague-Dawley rat. 29 Apr 2009
• Comparison of five benzodiazepine-receptor agonists on buprenorphine-induced mu-opioid receptor regulation. 29 Apr 2009
• Dosimetry of 11C-carfentanil, a micro-opioid receptor imaging agent. 30 Mar 2009
• Ethanol-induced social facilitation in adolescent rats: role of endogenous activity at mu opioid receptors. 17 Mar 2009
• Neuropeptide VF-associated satiety involves mu and kappa but not delta subtypes of opioid receptors in chicks. 12 Mar 2009
• Role of mu- and delta-opioid receptors in the nucleus accumbens in cocaine-seeking behavior. 9 Mar 2009
• Gz mediates the long-lasting desensitization of brain CB1 receptors and is essential for cross-tolerance with morphine. 8 Mar 2009
• Allosteric modulation of metabotropic glutamate receptor 5 affects phosphorylation, internalization, and desensitization of the micro-opioid receptor. 27 Feb 2009
• Stimulatory effect of stevioside on peripheral mu opioid receptors in animals. 26 Feb 2009
• Activation of opioid micro-receptors in medullary raphe depresses sighs. 23 Feb 2009
• Motor stimulant effects of ethanol and acetaldehyde injected into the posterior ventral tegmental area of rats: role of opioid receptors. 22 Feb 2009
• Intravenous self-administration of etonitazene alone and combined with cocaine in rhesus monkeys: comparison with heroin and antagonism by naltrexone and naloxonazine. 17 Feb 2009
• An elephant among us: the role of dopamine in the pathophysiology of fibromyalgia. 30 Jan 2009
• Neuropeptide modulation of a lumbar spinal reflex: potential implications for female sexual function. 10 Jan 2009
• Role of protein kinase C and mu-opioid receptor (MOPr) desensitization in tolerance to morphine in rat locus coeruleus neurons. 30 Dec 2008
• Methylnaltrexone for treatment of opioid-induced constipation in advanced illness patients. 30 Dec 2008

See a longer list of these articles.

Technical information about 'Receptors, Opioid, mu'

Definition: A class of opioid receptors recognized by its pharmacological profile. Mu opioid receptors bind, in decreasing order of affinity, endorphins, dynorphins, met-enkephalin, and leu-enkephalin. They have also been shown to be molecular receptors for morphine.

Registry Number: 0

Descriptor UI: D017450

Alternative terms: Receptors, Opioid, mu; Opioid Receptors, mu; mu Opioid Receptors; Receptors, mu Opioid; Receptors, mu; mu Receptor; Receptor, mu; mu Receptors; mu Opioid Receptor; Opioid Receptor, mu; Receptor, mu Opioid; Morphine Receptor; Receptor, Morphine; Receptors, Morphine; Morphine Receptors;

Allowable Qualifiers: administration & dosage; analysis; antagonists & inhibitors; biosynthesis; blood; classification; deficiency; drug effects; genetics; history; immunology; isolation & purification; metabolism; physiology; radiation effects; therapeutic use; ultrastructure; chemistry; agonists;

Tree Number: D12.776.543.750.100.620.550; D12.776.543.750.720.600.610.550; D12.776.543.750.750.555.610.550;

Online Note: use RECEPTORS, OPIOID, MU to search RECEPTORS, MU 1993; use RECEPTORS, OPIOID, MU (NM) to search MU RECEPTOR 1981-92; use RECEPTORS, OPIOID to search MORPHINE RECEPTORS & RECEPTORS, MORPHINE 1977-94

History Note: 94; was RECEPTORS, MU 1993; was MU RECEPTOR (NM) 1981-92; MORPHINE RECEPTORS & RECEPTORS, MORPHINE were see RECEPTORS, OPIOID 1977-94

Technical Notes: opioid receptors found in the hypothalamus; DF: RECEPT MU