Receptors, Opioid, mu - Genetics
Research News and Information

Monday, November 23, 2009

[Side effects of opioid and gene variants]

30 Aug 2009 There are individual differences in the analgesic effect and the side effect of the opioid to which genetic variation may be related. Analysis of micro-opioid receptor knockout mice indicated that inhibition of gastrointestinal transit by morphine ... Read more...

[Postoperative pain management following orthognathic surgery in consideration of individual differences--is the antinociceptive effect of fentanyl related to the genotype involving nucleotide at OPRM1?]

30 Aug 2009 We experience individual differences in pain and sensitivity to analgesics clinically. Genetic factors are known to influence individual difference. Polymorphisms in the human OPRM1 gene, which encodes the micro-opioid receptors, may be associated ... Read more...

[Genetic polymorphisms and human sensitivity to pain and opioids]

30 Aug 2009 It has been known widely that sensitivity to pain and opioid analgesics varies widely among individual subjects. Because of this variability, a dose of an opioid analgesic that can produce satisfactory pain relief without adverse effects in some ... Read more...

Latest indexed articles for 'Receptors, Opioid, mu - Genetics'

These are the very latest articles for this heading:

• [Side effects of opioid and gene variants] 30 Aug 2009
• [Postoperative pain management following orthognathic surgery in consideration of individual differences--is the antinociceptive effect of fentanyl related to the genotype involving nucleotide at OPRM1?] 30 Aug 2009
• [Genetic polymorphisms and human sensitivity to pain and opioids] 30 Aug 2009
• [How can we cope with wide individual variations in pain intensity and opioid requirements after surgery?] 30 Aug 2009
• Mu opioid receptor from the zebrafish exhibits functional characteristics as those of mammalian mu opioid receptor. 30 Aug 2009
• Variation in the micro-opioid receptor gene (OPRM1) is associated with dispositional and neural sensitivity to social rejection. 12 Aug 2009
• Effect of genetic factors on opioid action. 30 Jul 2009
• Differential use of an in-frame translation initiation codon regulates human mu opioid receptor (OPRM1). 14 Jul 2009
• Mu-opioid receptor (A118G) single-nucleotide polymorphism affects alfentanil requirements for extracorporeal shock wave lithotripsy: a pharmacokinetic-pharmacodynamic study. 13 Jul 2009
• Predicting the effect of naltrexone and acamprosate in alcohol-dependent patients using genetic indicators. 29 Jun 2009
• Changes in mouse mu opioid receptor Exon 7/8-like immunoreactivity following food restriction and food deprivation in rats. 29 Jun 2009
• Questionable efficacy for naltrexone in patients with Asp40. 29 Jun 2009
• Acute and chronic fentanyl administration causes hyperalgesia independently of opioid receptor activity in mice. 22 Jun 2009
• Ethnicity and OPRM variant independently predict pain perception and patient-controlled analgesia usage for post-operative pain. 21 Jun 2009
• Purification and functional reconstitution of monomeric mu-opioid receptors: allosteric modulation of agonist binding by Gi2. 17 Jun 2009
• Functional characterization of human variants of the mu-opioid receptor gene. 13 Jun 2009
• Mouse model of OPRM1 (A118G) polymorphism has sex-specific effects on drug-mediated behavior. 13 Jun 2009
• Can heterogeneity of chronic sickle-cell disease pain be explained by genomics? A literature review. 30 May 2009
• Cross-sectional analysis of the influence of currently known pharmacogenetic modulators on opioid therapy in outpatient pain centers. 30 May 2009
• Pleiotropic effects of morphine-6beta-glucuronide. 30 May 2009

See a longer list of these articles.

Technical information about 'Receptors, Opioid, mu'

Definition: A class of opioid receptors recognized by its pharmacological profile. Mu opioid receptors bind, in decreasing order of affinity, endorphins, dynorphins, met-enkephalin, and leu-enkephalin. They have also been shown to be molecular receptors for morphine.

Registry Number: 0

Descriptor UI: D017450

Alternative terms: Receptors, Opioid, mu; Opioid Receptors, mu; mu Opioid Receptors; Receptors, mu Opioid; Receptors, mu; mu Receptor; Receptor, mu; mu Receptors; mu Opioid Receptor; Opioid Receptor, mu; Receptor, mu Opioid; Morphine Receptor; Receptor, Morphine; Receptors, Morphine; Morphine Receptors;

Allowable Qualifiers: administration & dosage; analysis; antagonists & inhibitors; biosynthesis; blood; classification; deficiency; drug effects; genetics; history; immunology; isolation & purification; metabolism; physiology; radiation effects; therapeutic use; ultrastructure; chemistry; agonists;

Tree Number: D12.776.543.750.100.620.550; D12.776.543.750.720.600.610.550; D12.776.543.750.750.555.610.550;

Online Note: use RECEPTORS, OPIOID, MU to search RECEPTORS, MU 1993; use RECEPTORS, OPIOID, MU (NM) to search MU RECEPTOR 1981-92; use RECEPTORS, OPIOID to search MORPHINE RECEPTORS & RECEPTORS, MORPHINE 1977-94

History Note: 94; was RECEPTORS, MU 1993; was MU RECEPTOR (NM) 1981-92; MORPHINE RECEPTORS & RECEPTORS, MORPHINE were see RECEPTORS, OPIOID 1977-94

Technical Notes: opioid receptors found in the hypothalamus; DF: RECEPT MU