Receptors, Opioid
Research News and Information

Monday, November 23, 2009

Naloxone, but not flupenthixol, disrupts the development of conditioned ejaculatory preference in the male rat.

29 Sep 2009 Male rats display a conditioned preference to ejaculate with a female bearing an odor paired previously with copulation to ejaculation. The present study examined the role of endogenous opioid and dopamine systems in this preference. Male rats ... Read more...

The peripheral antinociceptive effects of endomorphin-1 and kynurenic acid in the rat inflamed joint model.

29 Sep 2009 BACKGROUND: Several data suggest that both opioid and N-methyl-d-aspartate (NMDA) receptors are localized at the peripheral level, and drugs acting on these receptors may produce antinociception after topical administration; however, the ... Read more...

Synthesis and evaluation of a full-agonist orvinol for PET-imaging of opioid receptors: [11C]PEO.

22 Sep 2009 Antagonist radiotracers have shown only a low sensitivity for detecting competition from high-efficacy agonists at opioid receptors (ORs) in vivo. We report that [(11)C]PEO binds with high affinity to mu and kappa-opioid receptors, is a full ... Read more...

Latest indexed articles for 'Receptors, Opioid'

These are the very latest articles for this heading:

• Naloxone, but not flupenthixol, disrupts the development of conditioned ejaculatory preference in the male rat. 29 Sep 2009
• The peripheral antinociceptive effects of endomorphin-1 and kynurenic acid in the rat inflamed joint model. 29 Sep 2009
• Synthesis and evaluation of a full-agonist orvinol for PET-imaging of opioid receptors: [11C]PEO. 22 Sep 2009
• Regulation of gonadotropin-releasing hormone secretion by kisspeptin/dynorphin/neurokinin B neurons in the arcuate nucleus of the mouse. 21 Sep 2009
• Discovery of orally active 3-pyridinyl-tropane as a potent nociceptin receptor agonist for the management of cough. 8 Sep 2009
• Influence of the side chain next to C-terminal benzimidazole in opioid pseudopeptides containing the Dmt-Tic pharmacophore. 8 Sep 2009
• [Pharmacodynamics of pain perception and polymorphism] 30 Aug 2009
• Revisiting tolerance from the endogenous morphine perspective. 30 Aug 2009
• Activation of the opioidergic descending pain control system underlies placebo analgesia. 25 Aug 2009
• Opioid growth factor-opioid growth factor receptor axis is a physiological determinant of cell proliferation in diverse human cancers. 10 Aug 2009
• Transient limb ischaemia remotely preconditions through a humoral mechanism acting directly on the myocardium: evidence suggesting cross-species protection. Aug 2009
• Expression of TRPV4 in the stimulated rat oral mucous membrane--nociceptive mechanisms of lingual conical papillae. 30 Jul 2009
• Methylnaltrexone, a peripherally acting opioid receptor antagonist, enhances tumoricidal effects of 5-Fu on human carcinoma cells. 30 Jul 2009
• The antinociceptive effects of intravenous dexmedetomidine in colorectal distension-induced visceral pain in rats: the role of opioid receptors. 30 Jul 2009
• Identification of an orally active opioid receptor-like 1 (ORL1) receptor antagonist 4-{3-[(2R)-2,3-dihydroxypropyl]-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl}-1-[(1S,3S,4R)-spiro[bicyclo[2.2.1]heptane-2,1'-cyclopropan]-3-ylmethyl]piperidine as clinical candidate. 21 Jul 2009
• Distinct opioid circuits determine the palatability and the desirability of rewarding events. 11 Jul 2009
• Synthesis and biological evaluation of imidazole derivatives as novel NOP/ORL1 receptor antagonists: exploration and optimization of alternative pyrazole structure. 29 Jun 2009
• Opioid receptor and NO/cGMP pathway as a mechanism of peripheral antinociceptive action of the cannabinoid receptor agonist anandamide. 29 Jun 2009
• Local antinociception induced by endothelin-1 in the hairy skin of the rat's back. 29 Jun 2009
• Synthesis and opioid receptor activity of indolopropellanes. 28 Jun 2009

See a longer list of these articles.

Technical information about 'Receptors, Opioid'

Definition: Cell membrane proteins that bind opioids and trigger intracellular changes which influence the behavior of cells. The endogenous ligands for opioid receptors in mammals include three families of peptides, the enkephalins, endorphins, and dynorphins. The receptor classes include mu, delta, and kappa receptors. Sigma receptors bind several psychoactive substances, including certain opioids, but their endogenous ligands are not known.

Registry Number: 0

Descriptor UI: D011957

Alternative terms: Receptors, Opioid; Opiate Receptors; Opioid Receptor; Receptor, Opioid; Opioid Receptors; Opiate Receptor; Receptor, Opiate; Receptors, Opiate; Receptors, Normorphine; Normorphine Receptors; Receptors, Narcotic; Narcotic Receptors; Enkephalin Receptor; Receptor, Enkephalin; Receptors, Enkephalin; Enkephalin Receptors; beta-Endorphin Receptor; Receptor, beta-Endorphin; beta Endorphin Receptor; Receptors, beta-Endorphin; Receptors, beta Endorphin; beta-Endorphin Receptors; Receptors, Endorphin; Endorphin Receptor; Receptor, Endorphin; Endorphin Receptors;

Allowable Qualifiers: administration & dosage; analysis; antagonists & inhibitors; biosynthesis; blood; classification; deficiency; drug effects; genetics; history; immunology; isolation & purification; metabolism; physiology; radiation effects; therapeutic use; ultrastructure; chemistry; agonists;

Tree Number: D12.776.543.750.100.620; D12.776.543.750.720.600.610; D12.776.543.750.750.555.610;

Online Note: use RECEPTORS, OPIOID to search RECEPTORS, ENDORPHIN 1980-93 & RECEPTORS, NARCOTIC 1977-79

History Note: 94; was RECEPTORS, ENDORPHIN 1980-93; was RECEPTORS, NARCOTIC 1977-79

Technical Notes: coord IM with specific opioid (IM); DF: RECEPT OPIOID