Receptors, Serotonin - Drug effects
Research News and Information

Sunday, November 22, 2009

Identification of novel indanylsulfonamide guanylhydrazones as potent 5-HT6 serotonin receptor antagonists.

6 Oct 2009 Changing the N,N-(dimethylamino)ethyl side chain in the N-[3-(aminoethyl)inden-5-yl]sulfonamide 5-HT(6) serotonin receptor agonists 1 by a conformationally rigid guanylhydrazone moiety at the indene 3-position led to the identification of the title ... Read more...

Serotonergic-postsynaptic receptors modulate gripping-induced immobility episodes in male taiep rats.

30 Aug 2009 The Taiep rat is a myelin mutant with a motor syndrome characterized by tremor, ataxia, immobility, epilepsy, and paralysis. The rat shows a hypomyelination followed by a progressive demyelination. During immobilities taiep rats show a REM-like ... Read more...

Drug-induced fibrotic valvular heart disease.

13 Aug 2009 The initial association between the development of valvular heart disease and drugs stems from observations made during the use of methysergide and ergotamine for migraine prophylaxis in the 1960s. Since then, the appetite suppressants fenfluramine ... Read more...

Latest indexed articles for 'Receptors, Serotonin - Drug effects'

These are the very latest articles for this heading:

• Identification of novel indanylsulfonamide guanylhydrazones as potent 5-HT6 serotonin receptor antagonists. 6 Oct 2009
• Effects of chronic blockade of 5-HT(6) receptors on NMDA receptor subunits expression. 30 Aug 2009
• Serotonergic-postsynaptic receptors modulate gripping-induced immobility episodes in male taiep rats. 30 Aug 2009
• Drug-induced fibrotic valvular heart disease. 13 Aug 2009
• Dimebolin is a 5-HT6 antagonist with acute cognition enhancing activities. 19 Jun 2009
• Human 5-HT7 receptor-induced inactivation of forskolin-stimulated adenylate cyclase by risperidone, 9-OH-risperidone and other "inactivating antagonists". 7 Jun 2009
• Interactions of Magnolia and Ziziphus extracts with selected central nervous system receptors. 4 Jun 2009
• Serotonin neuron-dependent and -independent reduction of dyskinesia by 5-HT1A and 5-HT1B receptor agonists in the rat Parkinson model. Jun 2009
• PSD-95 is essential for hallucinogen and atypical antipsychotic drug actions at serotonin receptors. Jun 2009
• Aripiprazole in L-dopa-induced dyskinesias: a one-year open-label pilot study. 10 May 2009
• Synthesis and biological evaluation of novel gamma-carboline analogues of Dimebon as potent 5-HT6 receptor antagonists. May 2009
• Identification of a novel series of 3-piperidinyl-5-sulfonylindazoles as potent 5-HT6 ligands. May 2009
• Differences in the dynamics of serotonin reuptake transporter occupancy may explain superior clinical efficacy of escitalopram versus citalopram. 29 Apr 2009
• New light on the serotonergic paradox in the rat circadian system. 25 Apr 2009
• Short-term erythrosine B-induced inhibition of the brain regional serotonergic activity suppresses motor activity (exploratory behavior) of young adult mammals. Mar 2009
• 5-hydroxyindalpine, an agonist at the putative 5-HT receptor, has no activity on human recombinant monoamine receptors but accelerates distension-induced peristalsis in mouse isolated colon. 28 Feb 2009
• 5-HT-induced depression of the spinal monosynaptic reflex potential utilizes different types of 5-HT receptors depending on Mg2+ availability. 27 Feb 2009
• Methylphenidate to adolescent rats drives enduring changes of accumbal Htr7 expression: implications for impulsive behavior and neuronal morphology. 17 Feb 2009
• 5-HT antagonists NAN-190 and SB 269970 block alpha2-adrenoceptors in the guinea pig. 16 Feb 2009
• Indene-based scaffolds. 2. An indole-indene switch: discovery of novel indenylsulfonamides as 5-HT6 serotonin receptor agonists. 10 Feb 2009

See a longer list of these articles.

Technical information about 'Receptors, Serotonin'

Definition: Cell-surface proteins that bind SEROTONIN and trigger intracellular changes which influence the behavior of cells. Several types of serotonin receptors have been recognized which differ in their pharmacology, molecular biology, and mode of action.

Registry Number: 0

Descriptor UI: D011985

Alternative terms: Receptors, Serotonin; 5-Hydroxytryptamine Receptors; 5 Hydroxytryptamine Receptors; 5-HT Receptors; 5 HT Receptors; Receptors, 5-HT; Receptors, 5 HT; Receptors, 5-Hydroxytryptamine; Receptors, 5 Hydroxytryptamine; Serotonin Receptors; Receptors, Tryptamine; Tryptamine Receptors;

Allowable Qualifiers: administration & dosage; analysis; biosynthesis; blood; classification; deficiency; drug effects; genetics; history; immunology; isolation & purification; metabolism; physiology; radiation effects; therapeutic use; ultrastructure; chemistry;

Tree Number: D12.776.543.750.070.800; D12.776.543.750.100.800; D12.776.543.750.720.300.800;

History Note: 77

Technical Notes: GEN; prefer specifics; DF: RECEPT SEROTONIN