Receptors, Thyroid Hormone
Research News and Information

Saturday, March 20, 2010

Therapy of experimental type 1 diabetes by isolated Sertoli cell xenografts alone.

10 Oct 2009 Type I diabetes mellitus is caused by autoimmune destruction of pancreatic beta cells, and effective treatment of the disease might require rescuing beta cell function in a context of reinstalled immune tolerance. Sertoli cells (SCs) are found in ... Read more...

Id2-, RORgammat-, and LTbetaR-independent initiation of lymphoid organogenesis in ocular immunity.

10 Oct 2009 The eye is protected by the ocular immunosurveillance system. We show that tear duct-associated lymphoid tissue (TALT) is located in the mouse lacrimal sac and shares immunological characteristics with mucosa-associated lymphoid tissues (MALTs), ... Read more...

Differential expression of interleukin-17A and -17F is coupled to T cell receptor signaling via inducible T cell kinase.

6 Oct 2009 T helper 17 (Th17) cells play major roles in autoimmunity and bacterial infections, yet how T cell receptor (TCR) signaling affects Th17 cell differentiation is relatively unknown. We demonstrate that CD4(+) T cells lacking Itk, a tyrosine kinase ... Read more...

Latest indexed articles for 'Receptors, Thyroid Hormone'

These are the very latest articles for this heading:

• Therapy of experimental type 1 diabetes by isolated Sertoli cell xenografts alone. 10 Oct 2009
• Id2-, RORgammat-, and LTbetaR-independent initiation of lymphoid organogenesis in ocular immunity. 10 Oct 2009
• Differential expression of interleukin-17A and -17F is coupled to T cell receptor signaling via inducible T cell kinase. 6 Oct 2009
• IFN-beta inhibits human Th17 cell differentiation. 23 Sep 2009
• The nuclear receptor PPAR gamma selectively inhibits Th17 differentiation in a T cell-intrinsic fashion and suppresses CNS autoimmunity. 6 Sep 2009
• Thymic self-reactivity selects natural interleukin 17-producing T cells that can regulate peripheral inflammation. 4 Sep 2009
• Genetic alterations in differentiated thyroid cancers. 30 Aug 2009
• The hypoxia-inducible factor 1/NOR-1 axis regulates the survival response of endothelial cells to hypoxia. 29 Aug 2009
• Thyroid receptor: roles in cancer. 24 Aug 2009
• Expression of Th1 and Th17 cytokines and transcription factors in multiple sclerosis patients: does baseline T-bet mRNA predict the response to interferon-beta treatment? 17 Aug 2009
• Encephalitogenic T cells that stably express both T-bet and ROR gamma t consistently produce IFNgamma but have a spectrum of IL-17 profiles. 16 Aug 2009
• Common polymorphisms within the NR4A3 locus, encoding the orphan nuclear receptor Nor-1, are associated with enhanced beta-cell function in non-diabetic subjects. 12 Aug 2009
• Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity. 11 Aug 2009
• Interleukin-17-producing gammadelta T cells selectively expand in response to pathogen products and environmental signals. 11 Aug 2009
• Berberine differentially modulates the activities of ERK, p38 MAPK, and JNK to suppress Th17 and Th1 T cell differentiation in type 1 diabetic mice. 4 Aug 2009
• The T helper 17-regulatory T cell axis in transplant rejection and tolerance. 30 Jul 2009
• T helper type 17-related cytokine expression is increased in the bronchial mucosa of stable chronic obstructive pulmonary disease patients. 30 Jul 2009
• IL-17-producing CD8+ T lymphocytes from psoriasis skin plaques are cytotoxic effector cells that secrete Th17-related cytokines. 30 Jul 2009
• Th17 transcription factor RORC2 is inversely correlated with FOXP3 expression in the joints of children with juvenile idiopathic arthritis. 29 Jul 2009
• TR4 nuclear receptor functions as a fatty acid sensor to modulate CD36 expression and foam cell formation. 26 Jul 2009

See a longer list of these articles.

Technical information about 'Receptors, Thyroid Hormone'

Definition: Specific high affinity binding proteins for THYROID HORMONES in target cells. They are usually found in the nucleus and regulate DNA transcription. These receptors are activated by hormones that leads to transcription, cell differentiation, and growth suppression. Thyroid hormone receptors are encoded by two genes (GENES, ERBA): erbA-alpha and erbA-beta for alpha and beta thyroid hormone receptors, respectively.

Registry Number: 0

Descriptor UI: D011988

Alternative terms: Receptors, Thyroid Hormone; Thyroid Hormone Receptors; Thyroid Hormone Receptor; Receptors, Triiodothyronine; Receptors, T3; Triiodothyronine Receptors; T3 Receptor; T3 Receptors; Receptors, Thyroxine; Thyroxine Receptors; T4 Receptors; Thyroxine Receptor; Receptors, T4; T4 Receptor; Receptors, Diiodotyrosine; Receptors, DIT; DIT Receptors; Diiodotyrosine Receptor; Diiodotyrosine Receptors; Receptors, Monoiodotyrosine; Monoiodotyrosine Receptors; Receptors, MIT; MIT Receptors;

Related Mesh Headings: Thyroid Hormone Resistance Syndrome;

Allowable Qualifiers: administration & dosage; analysis; antagonists & inhibitors; biosynthesis; blood; classification; deficiency; drug effects; genetics; history; immunology; isolation & purification; metabolism; physiology; radiation effects; therapeutic use; ultrastructure; chemistry; agonists;

Tree Number: D12.776.624.664.700.830; D12.776.826.850; D12.776.930.691;

Online Note: use RECEPTORS, THYROID HORMONE (NM) to search PROTO-ONCOGENE PROTEIN ERBA 1987-93

History Note: 87; PROTO-ONCOGENE PROTEIN ERBA was (NM) 1987-93

Technical Notes: coord IM with specific thyroid hormone (IM); DF: RECEPT THYROID HORMONE