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Repressor Proteins - Antagonists & inhibitors
Research News and Information
Definition of 'Repressor Proteins'Proteins which are normally bound to the operator locus of an operon, thereby preventing transcription of the structural genes. In enzyme induction, the substrate of the inducible enzyme binds to the repressor protein, causing its release from the operator and freeing the structural genes for transcription. In enzyme repression, the end product of the enzyme sequence binds to the free repressor protein, the resulting complex then binds to the operator and prevents transcription of the structural genes. |
Sunday, November 22, 2009
Antidepressant actions of histone deacetylase inhibitors.
14 Sep 2009 
Persistent symptoms of depression suggest the involvement of stable molecular adaptations in brain, which may be reflected at the level of chromatin remodeling. We find that chronic social defeat stress in mice causes a transient decrease, followed ... Read more...
Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate.
2 Sep 2009 The pleiotropic lipid mediator sphingosine-1-phosphate (S1P) can act intracellularly independently of its cell surface receptors through unknown mechanisms. Sphingosine kinase 2 (SphK2), one of the isoenzymes that generates S1P, was associated with ... Read more...
23 Aug 2009 Chromobox protein homologue 7 (CBX7) is a chromobox family protein encoding a novel polycomb protein, the expression of which shows a progressive reduction, well related with the malignant grade of the thyroid neoplasias. Indeed, CBX7 protein levels ... Read more...
Latest indexed articles for 'Repressor Proteins - Antagonists & inhibitors'
These are the very latest articles for this heading:
- Antidepressant actions of histone deacetylase inhibitors. 14 Sep 2009
- Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate. 2 Sep 2009
- Chromobox protein homologue 7 protein, with decreased expression in human carcinomas, positively regulates E-cadherin expression by interacting with the histone deacetylase 2 protein. 23 Aug 2009
- Abrogation of TGF-beta1-induced fibroblast-myofibroblast differentiation by histone deacetylase inhibition. 19 Aug 2009
- Targeted inhibition of Snail family zinc finger transcription factors by oligonucleotide-Co(III) Schiff base conjugate. Aug 2009
- A quorum-sensing antagonist targets both membrane-bound and cytoplasmic receptors and controls bacterial pathogenicity. 29 Jul 2009
- Sufu recruits GSK3beta for efficient processing of Gli3. 17 Jul 2009
- Neutrophil elastase represses IL-8/CXCL8 synthesis in human airway smooth muscle cells through induction of NF-kappa B repressing factor. 29 Jun 2009
- Repression of BMI1 in normal and leukemic human CD34(+) cells impairs self-renewal and induces apoptosis. 23 Jun 2009
- Histone deacetylase-2 is a key regulator of diabetes- and transforming growth factor-beta1-induced renal injury. 22 Jun 2009
- PRMT5 is required for cell-cycle progression and p53 tumor suppressor function. 13 Jun 2009
- Alpha-keto acid metabolites of organoselenium compounds inhibit histone deacetylase activity in human colon cancer cells. 13 Jun 2009
- McsB is a protein arginine kinase that phosphorylates and inhibits the heat-shock regulator CtsR. 3 Jun 2009
- Ethyl pyruvate attenuates spinal cord ischemic injury with a wide therapeutic window through inhibiting high-mobility group box 1 release in rabbits. 30 May 2009
- HDAC2 negatively regulates memory formation and synaptic plasticity. 5 May 2009
- Synthetic EthR inhibitors boost antituberculous activity of ethionamide. May 2009
- HDAC5 is a repressor of angiogenesis and determines the angiogenic gene expression pattern of endothelial cells. 5 Apr 2009
- The synovial sarcoma-associated SYT-SSX2 oncogene antagonizes the polycomb complex protein Bmi1.
30 Mar 2009 - TGF-beta modulates the functionality of tumor-infiltrating CD8+ T cells through effects on TCR signaling and Spred1 expression. 23 Mar 2009
- CK2 phosphorylation of the PRH/Hex homeodomain functions as a reversible switch for DNA binding. 23 Mar 2009
See a longer list of these articles.
Technical information about 'Repressor Proteins'
Definition: Proteins which are normally bound to the operator locus of an operon, thereby preventing transcription of the structural genes. In enzyme induction, the substrate of the inducible enzyme binds to the repressor protein, causing its release from the operator and freeing the structural genes for transcription. In enzyme repression, the end product of the enzyme sequence binds to the free repressor protein, the resulting complex then binds to the operator and prevents transcription of the structural genes.
Registry Number: 0
Descriptor UI: D012097
Alternative terms: Repressor Proteins; Proteins, Repressor; Repressor Molecules; Molecules, Repressor; Lac Repressors; Repressors, Lac;
Allowable Qualifiers: supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists; administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards;
Tree Number: D12.776.930.700;
History Note: 91(79); was see under TRANSCRIPTION FACTORS 1979-90
Technical Notes: transcription factors; /biosyn /drug eff /physiol permitted