Repressor Proteins - Metabolism
Research News and Information

Monday, November 23, 2009

Ring1B contains a ubiquitin-like docking module for interaction with Cbx proteins.

8 Nov 2009 Polycomb group (PcG) proteins are a special set of repressive transcription factors involved in epigenetic modifications of chromatin. They form two functionally distinct groups of catalytically active complexes: Polycomb repressive complex 1 (PRC1) ... Read more...

Necdin: a multi functional protein with potential tumor suppressor role?

30 Oct 2009 Necdin (NDN), a member of the melanoma-associated antigen (MAGE) family of proteins was first identified in mouse stem cells of embryonal carcinoma origin induced to differentiate by treatment with retinoic acid. The human gene maps to chromosome ... Read more...

Polycomb group proteins: navigators of lineage pathways led astray in cancer.

30 Oct 2009 The Polycomb group (PcG) proteins are transcriptional repressors that regulate lineage choices during development and differentiation. Recent studies have advanced our understanding of how the PcG proteins regulate cell fate decisions and how their ... Read more...

Latest indexed articles for 'Repressor Proteins - Metabolism'

These are the very latest articles for this heading:

• Ring1B contains a ubiquitin-like docking module for interaction with Cbx proteins. 8 Nov 2009
• Necdin: a multi functional protein with potential tumor suppressor role? 30 Oct 2009
• Polycomb group proteins: navigators of lineage pathways led astray in cancer. 30 Oct 2009
• Recruitment of polycomb group complexes and their role in the dynamic regulation of cell fate choice. 30 Oct 2009
• RUNX3-mediated repression of RUNX1 in B cells. 30 Oct 2009
• Biochemical characterization of the multidrug regulator QacR distinguishes residues that are crucial to multidrug binding and induction of qacA transcription. 18 Oct 2009
• Spred2 interaction with the late endosomal protein NBR1 down-regulates fibroblast growth factor receptor signaling. 10 Oct 2009
• Functional characterization of the interactions between endosomal adaptor protein APPL1 and the NuRD co-repressor complex. 10 Oct 2009
• Modulation of vitamin d receptor activity by the corepressor hairless: differential effects of hairless isoforms. 7 Oct 2009
• CCCTC-binding factor and the transcription factor T-bet orchestrate T helper 1 cell-specific structure and function at the interferon-gamma locus. 6 Oct 2009
• Prohibitin couples diapause signalling to mitochondrial metabolism during ageing in C. elegans. 6 Oct 2009
• FIH-dependent asparaginyl hydroxylation of ankyrin repeat domain-containing proteins. 29 Sep 2009
• Novel features of boundary cap cells revealed by the analysis of newly identified molecular markers. 29 Sep 2009
• Drug discovery: Propping up a destructive regime. 29 Sep 2009
• Meis2 competes with the Groucho co-repressor Tle4 for binding to Otx2 and specifies tectal fate without induction of a secondary midbrain-hindbrain boundary organizer. 29 Sep 2009
• X-radiation induces non-small-cell lung cancer apoptosis by upregulation of Axin expression. 29 Sep 2009
• Self-renewing epiblast stem cells exhibit continual delineation of germ cells with epigenetic reprogramming in vitro. 28 Sep 2009
• Groucho corepressor functions as a cofactor for the Knirps short-range transcriptional repressor. 26 Sep 2009
• E3 ubiquitin ligase COP1 regulates the stability and functions of MTA1. 22 Sep 2009
• Histone chaperones ASF1 and NAP1 differentially modulate removal of active histone marks by LID-RPD3 complexes during NOTCH silencing. 22 Sep 2009

See a longer list of these articles.

Technical information about 'Repressor Proteins'

Definition: Proteins which are normally bound to the operator locus of an operon, thereby preventing transcription of the structural genes. In enzyme induction, the substrate of the inducible enzyme binds to the repressor protein, causing its release from the operator and freeing the structural genes for transcription. In enzyme repression, the end product of the enzyme sequence binds to the free repressor protein, the resulting complex then binds to the operator and prevents transcription of the structural genes.

Registry Number: 0

Descriptor UI: D012097

Alternative terms: Repressor Proteins; Proteins, Repressor; Repressor Molecules; Molecules, Repressor; Lac Repressors; Repressors, Lac;

Allowable Qualifiers: supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists; administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards;

Tree Number: D12.776.930.700;

History Note: 91(79); was see under TRANSCRIPTION FACTORS 1979-90

Technical Notes: transcription factors; /biosyn /drug eff /physiol permitted