Reversal Learning - Drug effects
Research News and Information

Saturday, November 21, 2009

Double dissociation and hierarchical organization of strategy switches and reversals in the rat PFC.

29 Sep 2009 Prelimbic-infralimbic cortex (PL-IL) and orbitofrontal cortex (OFC) influence behavioral flexibility in the rat. The authors tested the effects of PL-IL or OFC infusion with the GABA agonist muscimol in the context of 2 flexible responding tasks: ... Read more...

Spatial discrimination reversal learning in weanling rats is impaired by striatal administration of an NMDA-receptor antagonist.

25 Aug 2009 The striatum plays a major role in both motor control and learning and memory, including executive function and "behavioral flexibility." Lesion, temporary inactivation, and infusion of an N-methyl-d-aspartate (NMDA)-receptor antagonist into the ... Read more...

Management of sleep/wake cycles improves cognitive function in a transgenic mouse model of Huntington's disease.

16 May 2009 Normally, mice sleep during the day and are active at night. In Huntington's disease mice (R6/2 line) this circadian pattern disintegrates progressively over the course of their illness. Cognitive decline and apathy in R6/2 mice can be improved with ... Read more...

Latest indexed articles for 'Reversal Learning - Drug effects'

These are the very latest articles for this heading:

• Double dissociation and hierarchical organization of strategy switches and reversals in the rat PFC. 29 Sep 2009
• Spatial discrimination reversal learning in weanling rats is impaired by striatal administration of an NMDA-receptor antagonist. 25 Aug 2009
• Management of sleep/wake cycles improves cognitive function in a transgenic mouse model of Huntington's disease. 16 May 2009
• A role for dopamine D2 receptors in reversal learning. May 2009
• Dopamine release in dissociable striatal subregions predicts the different effects of oral methylphenidate on reversal learning and spatial working memory. 13 Apr 2009
• Intrahippocampal administration of an NMDA-receptor antagonist impairs spatial discrimination reversal learning in weanling rats. 23 Feb 2009
• Striatal dopamine predicts outcome-specific reversal learning and its sensitivity to dopaminergic drug administration. 2 Feb 2009
• Chronic treatment with Delta(9)-tetrahydrocannabinol impairs spatial memory and reduces zif268 expression in the mouse forebrain. 30 Jan 2009
• Effect of an NCAM mimetic peptide FGL on impairment in spatial learning and memory after neonatal phencyclidine treatment in rats. 12 Dec 2008
• Effect of methamphetamine neurotoxicity on learning-induced Arc mRNA expression in identified striatal efferent neurons. 29 Nov 2008
• Acetylcholine activity in selective striatal regions supports behavioral flexibility. 24 Oct 2008
• Pre-surgical training ameliorates orbitofrontal-mediated impairments in spatial reversal learning. 13 Oct 2008
• Dopamine D2/D3 receptor agonist quinpirole impairs spatial reversal learning in rats: investigation of D3 receptor involvement in persistent behavior. Oct 2008
• Subchronic MK-801 behavioural deficits in rats: partial reversal by the novel nitrate GT 1061. 8 Sep 2008
• Repeated heroin in rats produces locomotor sensitization and enhances appetitive Pavlovian and instrumental learning involving food reward. 6 Aug 2008
• Intracranial administration of vaccinia virus complement control protein in Mo/Hu APPswe PS1dE9 transgenic mice at an early age shows enhanced performance at a later age using a cheese board maze test. 3 Aug 2008
• Inhibition of the norepinephrine transporter improves behavioral flexibility in rats and monkeys. 5 Jul 2008
• Spatial information processing consequences of DAMGO injections into the dorsal striatum. 22 Jun 2008
• Complete recovery of olfactory associative learning by activation of 5-HT4 receptors after dentate granule cell damage in rats. 13 May 2008
• MDMA-induced impairment in primates: antagonism by a selective norepinephrine or serotonin, but not by a dopamine/norepinephrine transport inhibitor. 26 Feb 2008

See a longer list of these articles.

Technical information about 'Reversal Learning'

Definition: Any situation where an animal or human is trained to respond differentially to two stimuli (e.g., approach and avoidance) under reward and punishment conditions and subsequently trained under reversed reward values (i.e., the approach which was previously rewarded is punished and vice versa).

Descriptor UI: D012193

Alternative terms: Reversal Learning; Learning, Reversal; Learnings, Reversal; Reversal Learnings;

Allowable Qualifiers: classification; drug effects; physiology; radiation effects; ethics;

Tree Number: F02.463.425.798;

History Note: 66(64)

Technical Notes: human & animal