RGS Proteins - Metabolism
Research News and Information

Monday, March 22, 2010

Isoflurane-induced changes in righting response and breathing are modulated by RGS proteins.

30 Oct 2009 BACKGROUND: Recent evidence suggests that G protein-coupled receptors, especially those linked to G(alpha)(i), contribute to the mechanisms of anesthetic action. Regulator of G protein signaling (RGS) proteins bind to activated G(alpha)(i) and ... Read more...

Marked induction of the helix-loop-helix protein Id3 promotes the gammadelta T cell fate and renders their functional maturation Notch independent.

14 Oct 2009 alphabeta and gammadelta T cells arise from a common thymocyte progenitor during development in the thymus. Emerging evidence suggests that the pre-T cell receptor (pre-TCR) and gammadelta T cell receptor (gammadeltaTCR) play instructional roles in ... Read more...

RGS9 concentration matters in rod phototransduction.

14 Sep 2009 The transduction of light by retinal rods and cones is effected by homologous G-protein cascades whose rates of activation and deactivation determine the sensitivity and temporal resolution of photoreceptor signaling. In mouse rods, the ... Read more...

Latest indexed articles for 'RGS Proteins - Metabolism'

These are the very latest articles for this heading:

• Isoflurane-induced changes in righting response and breathing are modulated by RGS proteins. 30 Oct 2009
• Marked induction of the helix-loop-helix protein Id3 promotes the gammadelta T cell fate and renders their functional maturation Notch independent. 14 Oct 2009
• RGS9 concentration matters in rod phototransduction. 14 Sep 2009
• Effects of spinophilin on the function of RGS8 regulating signals from M2 and M3-mAChRs. 24 Aug 2009
• Hippocampal long-term potentiation is enhanced in urethane-anesthetized RGS2 knockout mice. 30 Jul 2009
• The prostatic environment suppresses growth of androgen-independent prostate cancer xenografts: an effect influenced by testosterone. 30 Jul 2009
• Retina-specific GTPase accelerator RGS11/G beta 5S/R9AP is a constitutive heterotrimer selectively targeted to mGluR6 in ON-bipolar neurons. 20 Jul 2009
• Role of layer 6 of V2 visual cortex in object-recognition memory. Jul 2009
• Neuroscience. Remembering outside the box. Jul 2009
• Regulator of G protein signalling 16 is a target for a porcine circovirus type 2 protein. 29 Jun 2009
• RGS5, a hypoxia-inducible apoptotic stimulator in endothelial cells. 27 Jun 2009
• Breast cancer migration and invasion depend on proteasome degradation of regulator of G-protein signaling 4. 21 Jun 2009
• The R7 RGS protein family: multi-subunit regulators of neuronal G protein signaling. 10 Jun 2009
• RGS16 inhibits breast cancer cell growth by mitigating phosphatidylinositol 3-kinase signaling. 7 Jun 2009
• RGS11 interacts preferentially with R7BP over Galpha(oa)--characterization of Gbeta5-free RGS11. 31 May 2009
• Structural determinants of G-protein alpha subunit selectivity by regulator of G-protein signaling 2 (RGS2). 26 May 2009
• Histamine H(4) receptor-RGS fusion proteins expressed in Sf9 insect cells: a sensitive and reliable approach for the functional characterization of histamine H(4) receptor ligands. 19 May 2009
• Differential modulation of mu- and delta-opioid receptor agonists by endogenous RGS4 protein in SH-SY5Y cells. 3 May 2009
• alpha-Tocopherol decreases the somatostatin receptor-effector system and increases the cyclic AMP/cyclic AMP response element binding protein pathway in the rat dentate gyrus. 20 Apr 2009
• Role of molecular chaperones in G protein beta5/regulator of G protein signaling dimer assembly and G protein betagamma dimer specificity. 15 Apr 2009

See a longer list of these articles.

Technical information about 'RGS Proteins'

Definition: A large family of evolutionarily conserved proteins that function as negative regulators of HETEROTRIMERIC GTP-BINDING PROTEINS. RGS PROTEINS act by increasing the GTPase activity of the G alpha subunit of a heterotrimeric GTP-binding protein, causing it to revert to its inactive (GDP-bound) form.

Registry Number: 0

Descriptor UI: D020710

Alternative terms: RGS Proteins; Regulators of G-Protein Signaling Proteins; Regulators of G Protein Signaling Proteins; RGS Protein (G-Protein Signaling);

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;

Pharmacological Action: GTP Phosphohydrolase Activators;

Tree Number: D12.644.360.325.150.750; D12.776.402.150.750; D12.776.476.325.150.750;

History Note: 2000; for RGS PROTEIN (G-PROTEIN SIGNALING) use GTPASE-ACTIVATING PROTEINS (NM) 1997-1999

Technical Notes: do not confuse with GTP-BINDING PROTEIN REGULATORS; not the same as RGS tripeptide