Ribosome Inactivating Proteins, Type 1 - Pharmacology
Research News and Information

Sunday, November 22, 2009

Transition state analogues rescue ribosomes from saporin-L1 ribosome inactivating protein.

18 Oct 2009 Ribosome inactivating proteins (RIPs) catalyze the hydrolytic depurination of one or more adenosine residues from eukaryotic ribosomes. Depurination of the ribosomal sarcin-ricin tetraloop (GAGA) causes inhibition of protein synthesis and cellular ... Read more...

Inhibition of tumor growth by targeted toxins in mice is dramatically improved by saponinum album in a synergistic way.

30 Aug 2009 The application of targeted toxins in cancer therapy remains a challenge due to the severe side effects as a consequence of the high systemic doses required. Here, we describe the combined application of a glycosylated triterpenoid (Spn) and ... Read more...

The neurokinin-1 receptor modulates the methamphetamine-induced striatal apoptosis and nitric oxide formation in mice.

11 Aug 2009 In a previous study we showed that pharmacological blockade of the neurokinin-1 receptors attenuated the methamphetamine (METH)-induced toxicity of the striatal dopamine terminals. In the present study we examined the role of the neurokinin-1 ... Read more...

Latest indexed articles for 'Ribosome Inactivating Proteins, Type 1 - Pharmacology'

These are the very latest articles for this heading:

• Transition state analogues rescue ribosomes from saporin-L1 ribosome inactivating protein. 18 Oct 2009
• Inhibition of tumor growth by targeted toxins in mice is dramatically improved by saponinum album in a synergistic way. 30 Aug 2009
• The neurokinin-1 receptor modulates the methamphetamine-induced striatal apoptosis and nitric oxide formation in mice. 11 Aug 2009
• Cellular basis of itch sensation. 4 Aug 2009
• Cell transplantation: a future therapy for narcolepsy? 30 Jul 2009
• Hypocretin-2 saporin lesions of the ventrolateral periaquaductal gray (vlPAG) increase REM sleep in hypocretin knockout mice. 20 Jul 2009
• Enhancement of saporin cytotoxicity by Gypsophila saponins--more than stimulation of endocytosis. 14 Jul 2009
• The basal forebrain cholinergic system is required specifically for behaviorally mediated cortical map plasticity. 4 May 2009
• Effects of chronic donepezil treatment and cholinergic deafferentation on parietal pyramidal neuron morphology. 29 Apr 2009
• Targeted ablation of cardiac sympathetic neurons reduces resting, reflex and exercise-induced sympathetic activation in conscious rats. 18 Mar 2009
• Effects of the selective lesions of cholinergic septohippocampal neurons on different forms of memory and learning process. 30 Dec 2008
• Neuropeptide Y receptor-expressing dorsal horn neurons: role in nocifensive reflex responses to heat and formalin. 22 Dec 2008
• Developmental forebrain cholinergic lesion and environmental enrichment: behaviour, CA1 cytoarchitecture and neurogenesis. Dec 2008
• Neuropathic pain is maintained by brainstem neurons co-expressing opioid and cholecystokinin receptors. 30 Nov 2008
• Type 1 ribosome-inactivating proteins - entomotoxic, oxidative and genotoxic action on Anticarsia gemmatalis (Hübner) and Spodoptera frugiperda (J.E. Smith) (Lepidoptera: Noctuidae). 26 Nov 2008
• Depurination within the intergenic region of Brome mosaic virus RNA3 inhibits viral replication in vitro and in vivo. 10 Nov 2008
• Enhanced cytotoxicity of saporin by polyamidoamine dendrimer conjugation and photochemical internalization. 29 Sep 2008
• Saporin induces multiple death pathways in lymphoma cells with different intensity and timing as compared to ricin. 28 Sep 2008
• Effects of hypocretin (orexin) neuronal loss on sleep and extracellular adenosine levels in the rat basal forebrain. 7 Sep 2008
• The role of cholinergic basal forebrain neurons in adenosine-mediated homeostatic control of sleep: lessons from 192 IgG-saporin lesions. 25 Aug 2008

See a longer list of these articles.

Technical information about 'Ribosome Inactivating Proteins, Type 1'

Definition: Ribosome inactivating proteins consisting of only the toxic A subunit, which is a polypeptide of around 30 kDa.

Registry Number: 0

Descriptor UI: D054789

Alternative terms: Ribosome Inactivating Proteins, Type 1;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications;

Tree Number: D08.811.277.450.430.700.500; D12.776.765.710.500;

History Note: 2008