Rift Valley fever virus - Genetics
Research News and Information

Sunday, March 21, 2010

Dual functions of Rift Valley fever virus NSs protein: inhibition of host mRNA transcription and post-transcriptional downregulation of protein kinase PKR.

30 Aug 2009 Rift Valley fever virus (RVFV), which belongs to the genus Phlebovirus, family Bunyaviridae, is a negative-stranded RNA virus carrying a single-stranded, tripartite RNA genome. RVFV is an important zoonotic pathogen transmitted by mosquitoes and ... Read more...

Non-infectious plasmid engineered to simulate multiple viral threat agents.

Mar 2009 The aim of this study was to design and construct a non-virulent simulant to replace several pathogenic viruses in the development of detection and identification methods in biodefense. A non-infectious simulant was designed and engineered to ... Read more...

NSs protein of rift valley fever virus induces the specific degradation of the double-stranded RNA-dependent protein kinase.

9 Feb 2009 Rift Valley fever virus (RVFV) continues to cause large outbreaks of acute febrile and often fatal illness among humans and domesticated animals in Africa, Saudi Arabia, and Yemen. The high pathogenicity of this bunyavirus is mainly due to the viral ... Read more...

Latest indexed articles for 'Rift Valley fever virus - Genetics'

These are the very latest articles for this heading:

• Dual functions of Rift Valley fever virus NSs protein: inhibition of host mRNA transcription and post-transcriptional downregulation of protein kinase PKR. 30 Aug 2009
• Non-infectious plasmid engineered to simulate multiple viral threat agents. Mar 2009
• NSs protein of rift valley fever virus induces the specific degradation of the double-stranded RNA-dependent protein kinase. 9 Feb 2009
• Rift Valley fever virus NSs protein promotes post-transcriptional downregulation of protein kinase PKR and inhibits eIF2alpha phosphorylation. 4 Feb 2009
• Using a field quantitative real-time PCR test to rapidly identify highly viremic rift valley fever cases. 24 Jan 2009
• Vaccination with virus-like particles protects mice from lethal infection of Rift Valley Fever Virus. 18 Jan 2009
• Efficient production of Rift Valley fever virus-like particles: The antiviral protein MxA can inhibit primary transcription of bunyaviruses. 17 Jan 2009
• Characterisation of immune responses and protective efficacy in mice after immunisation with Rift Valley Fever virus cDNA constructs. 15 Jan 2009
• Development and evaluation of a real-time reverse transcription-loop-mediated isothermal amplification assay for rapid detection of Rift Valley fever virus in clinical specimens. 22 Dec 2008
• Multiple virus lineages sharing recent common ancestry were associated with a Large Rift Valley fever outbreak among livestock in Kenya during 2006-2007. 8 Sep 2008
• Phi29 polymerase based random amplification of viral RNA as an alternative to random RT-PCR. 2 Sep 2008
• T7 RNA polymerase-dependent and -independent systems for cDNA-based rescue of Rift Valley fever virus. 30 Aug 2008
• Priming with DNA plasmids encoding the nucleocapsid protein and glycoprotein precursors from Rift Valley fever virus accelerates the immune responses induced by an attenuated vaccine in sheep. Aug 2008
• Rift Valley fever virus structural proteins: expression, characterization and assembly of recombinant proteins. 16 Jul 2008
• RNA polymerase I-mediated expression of viral RNA for the rescue of infectious virulent and avirulent Rift Valley fever viruses. 7 Jul 2008
• Kinetics of Rift Valley Fever Virus in experimentally infected mice using quantitative real-time RT-PCR. 31 May 2008
• Viral nucleic acid stabilization by RNA extraction reagent. 31 Mar 2008
• Rift valley fever virus lacking the NSs and NSm genes is highly attenuated, confers protective immunity from virulent virus challenge, and allows for differential identification of infected and vaccinated animals. 14 Jan 2008
• Rapid detection of important human pathogenic Phleboviruses. 17 Nov 2007
• NSm protein of Rift Valley fever virus suppresses virus-induced apoptosis. Oct 2007

See a longer list of these articles.

Technical information about 'Rift Valley fever virus'

Definition: A mosquito-borne species of the PHLEBOVIRUS genus found in eastern, central, and southern Africa, producing massive hepatitis, abortion, and death in sheep, goats, cattle, and other animals. It also has caused disease in humans.

Descriptor UI: D012296

Alternative terms: Rift Valley fever virus;

Allowable Qualifiers: classification; drug effects; enzymology; genetics; growth & development; immunology; isolation & purification; metabolism; pathogenicity; physiology; radiation effects; ultrastructure; chemistry;

Tree Number: B04.820.087.710.700; B04.909.777.147.710.700;

Online Note: use ARBOVIRUSES to search RIFT VALLEY FEVER VIRUS 1966-74

History Note: 91(75); was see under BUNYAVIRIDAE 1981-90; was see under ARBOVIRUSES 1975-80; was see under ARBOVIRUS 1965-74; was see under ARBORVIRUSES 1963-64

Technical Notes: infection = RIFT VALLEY FEVER